Results 141 to 150 of about 98,851 (337)

Involvement of the miR‐128‐3p/KDM3A/NLRP3 Axis in High Glucose‐Induced Inflammatory Injury in Retinal Endothelial Cells

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study explores the regulatory mechanism of the miR‐128‐3p in diabetic retinopathy (DR)‐associated inflammatory injury. A cellular model of DR was established by inducing immortalized human retinal endothelial cells (IM‐HRECs) with high‐glucose (HG).
Wei‐Ming Wen, Jian‐Bo Feng, Yin‐Sheng Cai, Nan Lin, Fei Lv, Zhu‐Sheng Guo   +5 more
wiley   +1 more source

Sacubitril/Valsartan Ameliorates Inflammation and Oxidative Stress in Hypertensive Heart Disease by Upregulating CAMKK2 Protein and Modulating the AMPK/AKT/GSK‐3β Axis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Sacubitril/valsartan (Sac/Val) has emerged as an effective compound with myocardium‐protective functions in experimental and clinical trials for heart failure. This study investigated the function of Sac/Val in hypertensive heart disease (HHD) and explored the underlying mechanism.
Yan‐Jun Yang, Jiu‐Sheng Li
wiley   +1 more source

The Small GTPase OsRac1 Forms Two Distinct Immune Receptor Complexes Containing the PRR OsCERK1 and the NLR Pit [PDF]

, 2021
Akira Akamatsu, Masayuki Fujiwara, Satoshi Hamada, Megumi Wakabayashi, Ai Yao, Qiong Wang, Ken‐ichi Kosami, Thu Thi Dang, Takako Kaneko‐Kawano, Fumi Fukada, Ko Shimamoto, Yoji Kawano   +11 more
openalex   +1 more source

Admission Plasma Lipopolysaccharide‐binding protein, Procalcitonin, and Lactate for Early Identification of Nosocomial Infection in Cirrhotic Patients With Upper Gastrointestinal Bleeding: A Retrospective Analysis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study aimed to assess whether admission plasma lipopolysaccharide‐binding protein (LBP), procalcitonin (PCT), and lactate could improve detection of nosocomial infection in cirrhotic patients presenting with upper gastrointestinal bleeding (UGIB).
Li Chen, Shan‐Shan Dun, Fang Xiao
wiley   +1 more source

Inflammatory Markers Stratify Surgical Outcomes in Pediatric Airway Reconstruction

The Laryngoscope, EarlyView.
ABSTRACT Objectives Red blood cell distribution width (RDW) predicts surgical success in adult patients undergoing open airway reconstruction for laryngotracheal stenosis, but similar biomarkers in pediatrics remain unidentified. This study identifies predictors of outcomes in pediatric patients undergoing triple endoscopy or surgical airway ...
Nomongo Dorjsuren, Hrithik Praveen, Kalpnaben Patel, Shilin Zhao, Alexander Gelbard, Christopher Wootten   +5 more
wiley   +1 more source

Cell autonomous and non-autonomous functions of plant intracellular immune receptors in stomatal defense and apoplastic defense.

PLoS Pathogens, 2019
Stomatal closure defense and apoplastic defense are two major immunity mechanisms restricting the entry and propagation of microbe pathogens in plants. Surprisingly, activation of plant intracellular immune receptor NLR genes, while enhancing whole plant
Jiapei Yan, Huiyun Yu, Bo Li, Anqi Fan, Jeffrey Melkonian, Xiue Wang, Tong Zhou, Jian Hua   +7 more
doaj   +1 more source

Advances and Prospects of Stereotactic Radiosurgery and Stereotactic Ablative Body Radiotherapy: Evolving Paradigms in Precision Oncology

Med Research, EarlyView.
The graphical abstract outlines the progressive development and impact of stereotactic radiosurgery (SRS) and stereotactic body radiotherapy (SBRT). Technological Evolution illustrates the transition from brachytherapy with single‐dose, LDR/HDR schedules to fractionated radiotherapy, three‐dimensional conformal radiotherapy (3DCRT) and Gamma Knife ...
Jing Zhang, Wenhao Xu, Weiqing Lu, Yingxuan Lin, Luoxi He, Zonglin Lv, Yiliyaer Nuerrula, Zouting, Zhen Zhang, Hailiang Zhang, Xuejun Ma   +10 more
wiley   +1 more source

Jurassic NLR: Conserved and dynamic evolutionary features of the atypically ancient immune receptor ZAR1 [PDF]

, 2023
Hiroaki Adachi, Toshiyuki Sakai, Jiorgos Kourelis, Hsuan Pai, José L. González-Hernández, Yoshinori Utsumi, Motoaki Seki, Abbas Maqbool, Sophien Kamoun   +8 more
openalex   +1 more source

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

Med Research, EarlyView.
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang, Ge Zhang, Tian‐Ding Liu, Tianshu Gu, Fengyi Yu, Pengyuan Xu, Wunan Mi, Xuanjiang Zhao, Qian Guo, Honglin Zheng, Taiqi Zhao, Qiang Li, Di Lu, Mingxuan Duan, Chaoyang Yu, Ruhao Wu, Shiqian Zhang, Haonan Zhang, Zeyu Wang, Youyang Zheng, Yan Xiao, Zenglei Zhang, Ge Zhang   +22 more
wiley   +1 more source

Characterization of NOD-like receptor-based molecular heterogeneity in glioma and its association with immune micro-environment and metabolism reprogramming

Frontiers in Immunology
Background and purposeThe characteristics and role of NOD-like receptor (NLR) signaling pathway in high-grade gliomas were still unclear. This study aimed to reveal the association of NLR with clinical heterogeneity of glioblastoma (GBM) patients, and to
Chunlin Lu, Huihao Ma, Jie Wang, Fei Sun, Fei Sun, Mingyang Fei, Ying Li, Jing Liu, Bin Dong   +8 more
doaj   +1 more source