Results 171 to 180 of about 98,851 (337)

[Recognition receptors of innate immunity (NLR, RLr, and CLR)].

Zhurnal mikrobiologii, epidemiologii i immunobiologii, 2011
Current concepts of recognition receptors of innate immunity (pattern-recognition receptors, PRR) are discussed in the review. Structural and functional features of receptors from the families NOD-like receptors (NLRs), RIG-like receptors (RLRs), and C-type lectin-like receptors (CLRs) are described.
D V, Koval'chuk, M V, Khoreva, A S, Nikonova   +2 more
openaire   +1 more source

Engineering nucleotide‐binding leucine‐rich repeat immune receptors to achieve broad‐spectrum disease resistance in plants

New Plant Protection, EarlyView.
Yan Wang, Yuzhen Mei, Fangfang Li
wiley   +1 more source

Protein tyrosine phosphatases as emerging targets for cancer immunotherapy

British Journal of Pharmacology, EarlyView.
Abstract Contemporary strategies in cancer immunotherapy, despite remarkable success, remain constrained by inherent limitations such as suboptimal patient responses, the emergence of drug resistance, and the manifestation of pronounced adverse effects. Consequently, the need for alternative strategies for immunotherapy becomes clear.
Zihan Qu, Jiajun Dong, Zhong‐Yin Zhang
wiley   +1 more source

Anti‐inflammatory effects of physical stimuli: The central role of networks in shaping the future of pharmacological research

British Journal of Pharmacology, EarlyView.
Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi, Reyhaneh Hooshmandabbasi, Alessandro Ravoni, Ying Ma, Luigi Manni, Timothy J. Koh, Caroline Maake, Tiziana Guarnieri, Darong Lai, Vitalii Zablotskii, Christine Nardini   +10 more
wiley   +1 more source

Bioengineering a plant NLR immune receptor with a robust binding interface towards a conserved fungal pathogen effector [PDF]

Rafał Zdrzałek, Yuxuan Xi, Thorsten Langner, Adam R. Bentham, Yohann Petit, Juan Carlos De la Concepción, Adeline Harant, Motoki Shimizu, Vincent Were, Nicholas J. Talbot, Ryohei Terauchi, Sophien Kamoun, Mark J. Banfield   +12 more
openalex   +1 more source

Identification and characterization of Receptor-Like Cytoplasmic Kinases (RLCKs) important in NLR-mediated immunity

, 2022
Hoda Yaghmaiean
openalex   +1 more source

Lactate Accelerates Early Angiogenesis and Bone Regeneration Through Macrophage M1 Polarisation

Cell Proliferation, EarlyView.
During the early stage of bone defect healing, lactate accumulates and contributes to increasing NOD1 expression by stabilising HIF1α that in turn triggers a calcium influx, which ultimately polarises macrophages towards the M1 phenotype and accelerates vascularisation of endothelial cells.
Lulu Liu, Danning Ma, Jia Song, Boon Chin Heng, Ying Huang, Xuehui Zhang, Mingming Xu, Yan Wei, Tai Wei, Jinqi Wei, Xuliang Deng   +10 more
wiley   +1 more source

Dapansutrile preserves pancreatic beta‐cell function by regulating insulin vesicle membrane fusion and mitochondrial homeostasis

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims/Hypothesis Pancreatic beta‐cell dysfunction is pivotal in diabetes pathogenesis, with the NOD‐like receptor protein 3 (NLRP3) inflammasome playing a crucial role. Dapansutrile (DAPA), a novel NLRP3 inhibitor, demonstrates promise in diabetes management.
Ying Wu, Hongxing Fu, Min Zhu, Yuanfa Yao, Luhong Jin, Xihua Lin, Jiaqiang Zhou   +6 more
wiley   +1 more source

Recognition of the Magnaporthe oryzae Effector AVR-Pia by the Decoy Domain of the Rice NLR Immune Receptor RGA5 [PDF]

, 2017
Diana Ortiz, Karine de Guillen, Stella Césari, Veronique Chalvon-Poulier, Jérôme Gracy, André Padilla, Thomas Kroj   +6 more
openalex   +1 more source

The Role of NLRP1, AIM2 and MEFV Inflammasomes in the High‐Intensity Interval Training of Individuals With Obesity

Immunology, EarlyView.
This study shows that 8 weeks of high‐intensity interval training (HIIT) modulate inflammasome‐related gene expression in individuals with obesity. HIIT increased AIM2, MEFV, CARD16 and CARD18 expression, with CARD16 upregulation supporting reduced inflammation through inhibition of caspase‐1 activation and lower IL‐1β levels.
Ana Luíza Pereira Assunção Silveira, Daniela Alves de Abreu, Amanda de Lima Santos Musto, Luiz Henrique da Silva Nali, Jônatas Bussador do Amaral, André Luis Lacerda Bachi, Marina Tiemi Shio, Paula Rezende‐Teixeira, Carolina Nunes França   +8 more
wiley   +1 more source