Results 271 to 280 of about 1,342,871 (301)

NOD‐like receptor (NLR) signaling beyond the inflammasome [PDF]

European Journal of Immunology, 2010
AbstractRecent years have witnessed a marked progress in our knowledge of NOD‐like receptors (NLR), intracellular sensors with central roles in innate and adaptive immunity. A majority of the research has focused on caspase‐1 inflammasomes. However, several members of the mammalian NLR family exert important roles in immunity beyond inflammasome ...
Thirumala-Devi Kanneganti
exaly   +3 more sources

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Molecular actions of NLR immune receptors in plants and animals

Science China Life Sciences, 2020
NLRs constitute intracellular immune receptors in both plants and animals. Direct or indirect ligand recognition results in formation of oligomeric NLR complexes to mediate immune signaling. Over the past 20 years, rapid progress has been made in our understanding of NLR signaling. Structural and biochemical studies provide insight into molecular basis
Wang, J., Chai, J.
openaire   +3 more sources

Advances in Nod-like receptors (NLR) biology

Cytokine & Growth Factor Reviews, 2014
The innate immune system is composed of a wide repertoire of conserved pattern recognition receptors (PRRs) able to trigger inflammation and host defense mechanisms in response to endogenous or exogenous pathogenic insults. Among these, nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) are intracellular sentinels of cytosolic ...
François, Barbé, Todd, Douglas, Maya, Saleh   +2 more
openaire   +2 more sources

Plant TRAF Proteins Regulate NLR Immune Receptor Turnover [PDF]

Cell Host and Microbe, 2016
In animals, Tumor necrosis factor receptor-associated factor (TRAF) proteins are molecular adaptors that regulate innate and adaptive immunity, development, and abiotic stress responses. Although gene families encoding TRAF domain-containing proteins exhibit enriched diversity in higher plants, their biological roles are poorly defined. Here, we report
Shuai Huang, Kevin Ao
exaly   +4 more sources

NLR surveillance of pathogen interference with hormone receptors induces immunity

Nature, 2022
Phytohormone signalling pathways have an important role in defence against pathogens mediated by cell-surface pattern recognition receptors and intracellular nucleotide-binding leucine-rich repeat class immune receptors1,2 (NLR). Pathogens have evolved counter-defence strategies to manipulate phytohormone signalling pathways to dampen immunity and ...
Jing Chen, Yanxiao Zhao, Xuanjie Luo, Hao Hong, Tongqing Yang, Shen Huang, Chunli Wang, Hongyu Chen, Xin Qian, Mingfeng Feng, Zhengqiang Chen, Yongxin Dong, Zhenchuan Ma, Jia Li, Min Zhu, Sheng Yang He, Savithramma P. Dinesh-Kumar, Xiaorong Tao   +17 more
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A nucleocytoplasmic-localized E3 ligase affects the NLR receptor stability

Biochemical and Biophysical Research Communications, 2021
Ubiquitination is a pivotal post-translational modification that regulates turnover of nucleotide-binding site and leucine-rich repeat receptors (NLRs). As a RING-type E3 ligase, BOI (Botrytis susceptible1 interactor) has been reported to interact with different proteins, and function in the nucleus.
Jianzhong Huang, Xiaoqiu Wu, Zhiyong Gao
openaire   +2 more sources

NLR immune receptor–nanobody fusions confer plant disease resistance [PDF]

Science, 2023
Plant pathogens cause recurrent epidemics, threatening crop yield and global food security. Efforts to retool the plant immune system have been limited to modifying natural components and can be nullified by the emergence of new pathogen strains. Made-to-order synthetic plant immune receptors provide an opportunity to tailor resistance to pathogen ...
Jiorgos Kourelis, Clemence Marchal, Andres Posbeyikian, Adeline Harant, Sophien Kamoun   +4 more
openaire   +3 more sources

Toll-like receptors (TLRs) and Nod-like receptors (NLRs) in inflammatory disorders

Seminars in Immunology, 2009
Toll-like receptors (TLRs) and Nod-like receptors (NLRs) are two major forms of innate immune sensors, which provide immediate responses against pathogenic invasion or tissue injury. Activation of these sensors induces the recruitment of innate immune cells such as macrophages and neutrophils, initiates tissue repair processes, and results in adaptive ...
Masayuki, Fukata, Arunan S, Vamadevan, Maria T, Abreu   +2 more
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Recent advances of NLR receptors in vegetable disease resistance

Plant Science
Plants mainly depend on both cell-surface and intracellular receptors to defend against various pathogens. The nucleotide-binding leucine-rich repeat (NLR) proteins are intracellular receptors that recognize pathogen effectors. The first NLR was cloned thirty years ago. Genomic sequencing and biotechnologies accelerated NLR gene isolation.
Qing, Wen, Shaoyun, Wang, Xiaolan, Zhang, Zhaoyang, Zhou   +3 more
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NLR receptor subcellular localization and plant immune activation

Current Opinion in Plant Biology
Nucleotide-binding and leucine-rich repeat receptor (NLR) proteins serve as cornerstone components of the plant immune system, typically recognizing pathogen effector proteins to assemble resistance complexes (resistosomes) that trigger robust immune responses.
Di Liang, Li Huang, Dehe Zhu, Yiwen Deng, Zuhua He   +4 more
openaire   +2 more sources