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Frontiers in Plant Science, 2023 Plants have evolved two layers of protection against biotic stress: PAMP-triggered immunity (PTI) and effector-triggered immunity (ETI). The primary mechanism of ETI involves nucleotide-binding leucine-rich repeat immune receptors (NLRs).
Xiang Li +17 more
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Intimate Association of PRR- and NLR-Mediated Signaling in Plant Immunity
Molecular Plant-Microbe Interactions, 2021 Plants recognize the presence or invasion of microbes through cell surface-localized pattern recognition receptors (PRRs) and intracellular nucleotide-binding domain leucine-rich repeat receptors (NLRs).
You Lu, Kenichi Tsuda
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NLRs, inflammasomes, and viral infection [PDF]
Journal of Leukocyte Biology, 2012 Abstract Review on the interplay between NLR proteins, and RNA and DNA viruses. NLR proteins are innate immune sensors that respond to microbial infection. Upon pathogen infection, some NLR proteins form large complexes, called inflammasomes, which activate caspase-1 and induce the production of active IL-1β and IL-18 ...
Sarah R, Jacobs, Blossom, Damania
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Agronomy, 2021 Sugarcane is an important sugar and potential energy crop, and the complexity of its genome has led to stagnant progress in genome decipherment and hindered the genome-wide analysis of the nucleotide binding site leucine-rich repeat (NLR) receptor until ...
Zhoutao Wang +5 more
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NLRs in immune privileged sites [PDF]
Current Opinion in Pharmacology, 2011 Innate immune receptors such as the nucleotide-binding domain, leucine-rich repeat-containing (NBD-LRR) receptors, referred to as NLRs, are known to serve as a critical component of host defense. However, their participation in inflammatory responses within immune privileged sites such as the brain and eye is less understood.
Holly L, Rosenzweig +2 more
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The Predictive Role of NLR, d-NLR, MLR, and SIRI in COVID-19 Mortality [PDF]
Diagnostics, 2022 (1) Background: Since its discovery, COVID-19 has caused more than 256 million cases, with a cumulative death toll of more than 5.1 million, worldwide. Early identification of patients at high risk of mortality is of great importance in saving the lives of COVID-19 patients.
Cosmin Citu +10 more
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BMC Immunology, 2009 Background The human innate immune system uses a system of extracellular Toll-like receptors (TLRs) and intracellular Nod-like receptors (NLRs) to match the appropriate level of immune response to the level of threat from the current environment.
Godzik Adam, Istomin Andrei Y
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Diverse
New Phytologist, 2019 Summary Most land plant genomes carry genes that encode RPW8‐NLR Resistance (R) proteins. Angiosperms carry two RPW8‐NLR subclasses: ADR1 and NRG1. ADR1s act as ‘helper’ NLRs for multiple TIR‐ and CC‐NLR R proteins in Arabidopsis. In angiosperm families, NRG1 co‐occurs with TIR‐NLR Resistance (R) genes.
Castel, Baptiste +7 more
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eLife, 2019 The molecular codes underpinning the functions of plant NLR immune receptors are poorly understood. We used in vitro Mu transposition to generate a random truncation library and identify the minimal functional region of NLRs.
Hiroaki Adachi +11 more
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PLoS Biology, 2021 Reference datasets are critical in computational biology. They help define canonical biological features and are essential for benchmarking studies. Here, we describe a comprehensive reference dataset of experimentally validated plant nucleotide-binding ...
Jiorgos Kourelis +3 more
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