Results 31 to 40 of about 20,544 (293)

Genome-Wide Identification, Characterization, and Comparative Analysis of NLR Resistance Genes in Coffea spp.

Frontiers in Plant Science, 2022
The largest family of disease resistance genes in plants are nucleotide-binding site leucine-rich repeat genes (NLRs). The products of these genes are responsible for recognizing avirulence proteins (Avr) of phytopathogens and triggering specific defense
Mariana de Lima Santos, Mário Lúcio Vilela de Resende, Gabriel Sérgio Costa Alves, Jose Carlos Huguet-Tapia, Márcio Fernando Ribeiro de Júnior Resende, Jeremy Todd Brawner   +5 more
doaj   +1 more source

Matching NLR Immune Receptors to Autoimmunity in camta3 Mutants Using Antimorphic NLR Alleles [PDF]

Cell Host & Microbe, 2017
To establish infection, pathogens deploy effectors to modify or remove host proteins. Plant immune receptors with nucleotide-binding, leucine-rich repeat domains (NLRs) detect these modifications and trigger immunity. Plant NLRs thus guard host "guardees." A corollary is that autoimmunity may result from inappropriate NLR activation because mutations ...
Lolle, Signe, Greeff, Michael Christiaan, Petersen, Klaus, Roux, Milena Edna, Jensen, Michael Krogh, Bressendorff, Simon, Rodriguez Gomes, Eleazar José, Sømark, Kenneth, Mundy, John, Petersen, Morten   +9 more
openaire   +4 more sources

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

Genome-wide functional analyses of plant coiled-coil NLR-type pathogen receptors reveal essential roles of their N-terminal domain in oligomerization, networking, and immunity.

PLoS Biology, 2018
The ability to induce a defense response after pathogen attack is a critical feature of the immune system of any organism. Nucleotide-binding leucine-rich repeat receptors (NLRs) are key players in this process and perceive the occurrence of nonself ...
Tadeusz Wróblewski, Laurentiu Spiridon, Eliza Cristina Martin, Andrei-Jose Petrescu, Keri Cavanaugh, Maria José Truco, Huaqin Xu, Dariusz Gozdowski, Krzysztof Pawłowski, Richard W Michelmore, Frank L W Takken   +10 more
doaj   +1 more source

Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Hepatology, EarlyView., 2022
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr, Benedikt Kaufmann, Maria Eugenia Inzaugarat, Theresa Maria Holtmann, Lukas Geisler, Jana Hundertmark, Marlene Sophia Kohlhepp, Laela M. Boosheri, Daisy R. Chilin‐Fuentes, Amanda Birmingham, Kathleen M. Fisch, Joel D. Schilling, Sven H. Loosen, Christian Trautwein, Christoph Roderburg, Münevver Demir, Frank Tacke, Hal M. Hoffman, Ariel E. Feldstein, Alexander Wree   +19 more
wiley   +1 more source

Expression profiles of NOD-like receptors and regulation of NLRP3 inflammasome activation in Toxoplasma gondii-infected human small intestinal epithelial cells

Parasites & Vectors, 2021
Background Toxoplasma gondii is a parasite that primarily infects through the oral route. Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) play crucial roles in the immune responses generated during parasitic infection and also drive
Jia-Qi Chu, Fei Fei Gao, Weiyun Wu, Chunchao Li, Zhaobin Pan, Jinhui Sun, Hao Wang, Cong Huang, Sang Hyuk Lee, Juan-Hua Quan, Young-Ha Lee   +10 more
doaj   +1 more source

Genome-wide characterization of the NLR gene family in tomato (Solanum lycopersicum) and their relatedness to disease resistance

Frontiers in Genetics, 2022
Nucleotide-binding leucine-rich-repeat receptors (NLR), the largest group of genes associated with plant disease resistance (R), have attracted attention due to their crucial role in protecting plants from pathogens.
Sehrish Bashir, Sehrish Bashir, Nazia Rehman, Nazia Rehman, Fabia Fakhar Zaman, Fabia Fakhar Zaman, Muhammad Kashif Naeem, Atif Jamal, Aurélien Tellier, Muhammad Ilyas, Gustavo Adolfo Silva Arias, Muhammad Ramzan Khan, Muhammad Ramzan Khan   +12 more
doaj   +1 more source

Structural mechanisms in NLR inflammasome signaling [PDF]

Current Opinion in Structural Biology, 2014
Members of the NOD-like receptor (NLR) family mediate the innate immune response to a wide range of pathogens, tissue damage and other cellular stresses. They achieve modulation of these signals by forming oligomeric signaling platforms, which in analogy to the apoptosome are predicted to adopt a defined oligomeric architecture and will here be ...
Bernhard C, Lechtenberg, Peter D, Mace, Stefan J, Riedl   +2 more
openaire   +2 more sources

Dynamic Diversity of NLR Genes in Triticum and Mining of Promising NLR Alleles for Disease Resistance

Current Issues in Molecular Biology, 2021
Bread wheat is an essential crop with the second-highest global production after maize. Currently, wheat diseases are a serious threat to wheat production. Therefore, efficient breeding for disease resistance is extremely urgent in modern wheat. Here, we
Xiaolong Li, Shifeng Cheng
doaj   +1 more source

COVID-19 HASTALARINDA NLR, d-NLR VE PLR'NİN HASTALIK CİDDİYETİ AÇISINDAN DEĞERLENDİRİLMESİ*

ANKEM Dergisi, 2023
İnflamasyonu ve bağışıklık durumunu temsil edebilen dolaşımdaki bazı biyobelirteçler, COVID-19 hastalarının prognozu için potansiyel öngörücü olabilmektedir. Periferik beyaz kan hücresi (WBC) sayısı, nötrofil-lenfosit oranı (NLR), türetilmiş NLR oranı [d-NLR, nötrofil sayısı/ (WBC sayısı- nötrofil sayısı)] ve trombosit-lenfosit oranı (PLR) viral ...
Muhammed BEKÇİBAŞI, Eyüp ARSLAN, Ömer Faruk ÖNDER   +2 more
openaire   +1 more source