Results 41 to 50 of about 20,544 (293)

Activation and regulation mechanisms of NOD-like receptors based on structural biology

Frontiers in Immunology, 2022
Innate immunity is a primary defense system against microbial infections. Innate immune pattern recognition receptors (PRRs) play pivotal roles in detection of invading pathogens.
Umeharu Ohto
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NLR diversity, helpers and integrated domains: making sense of the NLR IDentity

Current Opinion in Plant Biology, 2017
Plant innate immunity relies on genetically predetermined repertoires of immune receptors to detect pathogens and trigger an effective immune response. A large proportion of these receptors are from the Nucletoide Binding Leucine Rich Repeat (NLR) gene family.
E, Baggs, G, Dagdas, K V, Krasileva
openaire   +2 more sources

Rosetta Stone of NLR Innate Immunity [PDF]

Trends in Biochemical Sciences, 2016
The formation of NLR inflammasomes is a central step in the initiation of the innate immune response. Two recent publications describe the structure of the NAIP2-NLRC4 inflammasome and derive an elegant model of NLR inflammasome formation, whereby binding of the pathogen-molecule-bound NLR NAIP2 to NLRC4 leads to the activation of NLRC4 and initiation ...
Bernhard C, Lechtenberg, Stefan J, Riedl
openaire   +2 more sources

A Reference-Quality NLRome for the Hexaploid Sweetpotato and Diploid Wild Relatives

Molecular Plant-Microbe Interactions
Breeding for sweetpotato (Ipomea batatas) resistance requires accelerating our understanding of genomic sources of resistance. Nucleotide-binding domain leucine-rich repeat receptor (NLR) proteins represent a key component of the plant immune system that
C. H. Parada-Rojas, K. L. Childs, M. Fernández de Soto, A. Salcedo, K. Pecota, G. C. Yencho, C. Almeyda, J. P. Hamilton, M. Kitavi, C. R. Buell, G. C. Conant, D. Baltzegar, L. M. Quesada-Ocampo   +12 more
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Machine learning-based construction of a ferroptosis and necroptosis associated lncRNA signature for predicting prognosis and immunotherapy response in hepatocellular cancer

Frontiers in Oncology, 2023
IntroductionLiver hepatocellular carcinoma (LIHC), one of the most common malignancies worldwide, occurs with high incidence and mortality. Ferroptosis and necroptosis are critically associated with LIHC prognosis.
Lei Zhao, Zhixuan You, Zhixun Bai, Jian Xie   +3 more
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Generation of an Induced Pluripotent Stem Cell‐Derived Alveolar Type II In Vitro Model to Study Influenza A Virus Infection and Drug Treatments

Advanced Healthcare Materials, EarlyView.
Patient‐specific induced pluripotent stem cells (iPSCs) can be differentiated into alveolar type II cells (iAT2s), expanded as 3D alveolospheres, and grown at physiologically relevant air–liquid interface (ALI). This study shows for the first time the infectability of iAT2s by the influenza A virus (IAV) and proves their responsiveness to the well ...
Lena Gauthier, Hristina Koceva, Yann Bachelot, Rosanne W. Koutstaal, Puck B. van Kasteren, Marc Thilo Figge, Christian Eggeling, Alexander Sandy Mosig   +7 more
wiley   +1 more source

Editorial: NLR-Protein Functions in Immunity [PDF]

Frontiers in Immunology, 2015
Since Janeway (1) and Matzinger (2) put forward two distinct concepts of innate immune recognition, arguing that the driving force that initiates immune reponses is the recognition of microbial patterns or endogenous danger signals, respectively, we have acquired a tremendous wealth of knowledge of the protein families involved.
Fritz, Jörg H., Kufer, Thomas A.
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Advancing the Landscape of RNAi Nanotherapeutics for Ischemic Heart Disease

Advanced Materials, EarlyView.
RNA interference (RNAi) nanomedicine revolutionizes treatment regimens for ischemic heart diseases by enabling tailored, sequence‐anchored gene regulation. This review highlights the recent advances in nanotechnology‐driven RNAi therapeutics for myocardial ischemia and discusses the key design principles that govern efficient delivery, providing ...
Han Gao, Da Pan, Hélder A. Santos
wiley   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Construction and Identification of an NLR-Associated Prognostic Signature Revealing the Heterogeneous Immune Response in Skin Cutaneous Melanoma

Clinical, Cosmetic and Investigational Dermatology, 2023
Yi Geng,1 Yu-Jie Sun,1 Hao Song,1 Qiu-Ju Miao,1 Yi-Fei Wang,1 Jin-Liang Qi,2 Xiu-Lian Xu,1 Jian-Fang Sun1 1Institute of Dermatology, Peking Union Medical College and Chinese Academy of Medical Sciences, Nanjing, 210042, People’s Republic of China; 2State
Geng Y, Sun YJ, Song H, Miao QJ, Wang YF, Qi JL, Xu XL, Sun JF   +7 more
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