Results 141 to 150 of about 61,577 (309)

Pharmacokinetics and safety of highly variable nitroglycerin lingual spray (NLS) versus US-licensed nitroglycerin lingual spray reference product (Nitrolingual®): a randomized, four-cycle, four-sequence, partially replicated crossover Phase I bioequivalence clinical trial

Frontiers in Pharmacology
PurposeIn this Phase I study, we aimed to evaluate the pharmacokinetic bioequivalence and the safety of a nitroglycerin lingual spray (NLS) compared with US-approved Nitrolingual in healthy subjects.MethodsSubjects (N = 56) were randomized 1:1 to receive
Yingying Fang, Lu Qi, Yu Wang, Chunyu Han, Qian Zhang, Xiaoyun Liu, Ju Liu, Xiaoqiang Cheng, Yinjuan Li, Yan Li, Mingli Sun, Long Liu, Pu Li, Yingjuan Zhang, Huijuan Liu, Xinghe Wang   +15 more
doaj   +1 more source

Influence of the number and distribution of NLS peptides on the photosensitizing activity of multimeric porphyrin-NLS

, 2010
Porphyrin-peptide conjugates bearing multiple nuclear localization sequences (NLS) could show increased tumor cell uptake and affinity for nuclear receptors, and consequently increased photodynamic activity.
Sibrian-Vazquez, Martha, Jensen, Timothy J., Vicente, M. Graa H.   +2 more
core   +1 more source

Enhanced antioxidant performance of phlorotannin compounds from brown seaweed Sargassum tenerrimum via nanoliposomal encapsulation

Food Chemistry Advances
Seaweeds contain natural antioxidants, known as phlorotannins; however, their direct use in food is limited. Nanoliposomes (NLs) have small, uniform particle sizes (20 nm), a high entrapment efficiency (90 %), and good stability.
Esmat Mohammadi, Bahareh Shabanpour, Parastoo Pourashouri, Vahide Payamnoor, Salim Sharifian   +4 more
doaj   +1 more source

Adss1–HDAC3 Interaction: A Novel Mechanism for Epigenetic Regulation of Metabolism in Adipose Tissue

iNew Medicine, EarlyView.
ABSTRACT Obesity and its related metabolic disorders have emerged as global public health challenges with underlying mechanisms involving an imbalance between energy storage and expenditure in the adipose tissue. In recent years, with the deepening research on adipose tissue metabolism, the cross talk between metabolic enzymes and epigenetic regulation
Jiarui Zhao, Jingjing Sun, Yan Lu, Ying Yang   +3 more
wiley   +1 more source

Psychometric Evaluation and Clinical Norms of a Dutch Version of the Body Uneasiness Test Among Individuals With Self‐Reported Eating Disorder Pathology

Journal of Clinical Psychology, EarlyView.
ABSTRACT Introduction The present study evaluates the psychometric properties and provides normative data for the Dutch Body Uneasiness Test. The instrument was administered to a clinical sample (N = 448) and a community‐based sample (N = 223). The Body Uneasiness Test was translated and back‐translated.
Lanaya M. van Uffelen, Edwin de Beurs, Bernou Melisse   +2 more
wiley   +1 more source

Crystal structures of complexes of importin-αs and NLS ligands with close-up views showing the P1′-binding pocket in the minor NLS binding sites.

, 2015
(A) K128 of SV40 NLS peptide (Yeast importin-α: PDB ID: 1BK6), (B) K155 of Xenopus nucleoplasmin NLS (Yeast importin-α: 1EE5), (C) K537 of Xenopus nucleoplasmin NLS (importin-α2: 1PJN), (D) K738 of influenza virus polymerase subunit Pb2 (importin-α5 ...
Yuko Tatsumi (690327), Akira Sanjoh (690325), Yoko Aida (179321), Satoru Unzai (690326), Hideyuki Miyatake (690324), Yoichi Miyamoto (122118), Naoshi Dohmae (85096), Go Matsuda (195986)   +7 more
core   +1 more source

Application of Principal Component Analysis and Probabilistic Neural Networks in Ferralsols Recovery Evaluation Through Planting of Mabea Fistulifera and Eucalyptus Urograndis

Land Degradation &Development, EarlyView.
ABSTRACT This study presents an innovative assessment model for analyzing the evolution of degraded soils subjected to different reclamation strategies. The proposal combines statistical and artificial intelligence tools to jointly integrate multiple physical and chemical soil properties, allowing for a more synthetic view of the processes.
Melissa Alexandre Santos, Borja Velázquez‐Martí, Jorge João Delfim, Laura Silva Nantes, Jose Augusto Liberato de Souza, Gabriel Augusto da Silva Lunardelli, Dayara Vivian Alvares, Carolina dos Santos Batista Bonini   +7 more
wiley   +1 more source

Missense Variants in the A Isoform of FGF13 as a Novel Cause of Paroxysmal Dyskinesia

Movement Disorders, EarlyView.
Abstract Background Pathogenic variants within the unique N‐terminal inactivation particle of FGF13 isoform A (FGF13A) have so far been associated only with an X‐linked dominant epileptic encephalopathy (DEE). Objective The aim was to expand the clinical and molecular spectrum of FGF13A‐related disorder.
Cyril Mignot, Matthildi Athina Papathanasiou Terzi, Claudia Ravelli, Elisabeth Bosch, Xueqin Lin, Adeline Trauffler, Roseline Caumes, Andrew E. Fry, Clementine Fort, Gaelle Gauthe, Regina Trollmann, Thomas Wirth, Mathieu Anheim, Aurélie Méneret, Emmanuel Roze, Jean‐Madeleine de Sainte Agathe, Hailan He, Eleni Panagiotakaki, Gaëtan Lesca, André Reis, Diane Doummar, Thomas Smol, Georgia Vasileiou   +22 more
wiley   +1 more source

Resistance of Botrytis cinerea to anilinopyrimidine fungicides: A novel ARMS‐PCR method for the detection of Bcpos5 mutations and characterization of resistance using CRISPR/Cas9 editing

Pest Management Science, EarlyView.
A TETRA‐primer amplification refractory mutation system polymerase chain reaction (T‐ARMS‐PCR) method was developed for simultaneous detection of the L412F/V and G408V mutations. L412F/V mutants were created using the CRISPR/Cas tool and no fitness cost was observed.
Georgios Sofianos, Athanasios Petmezas, Anastasios Samaras, George Karaoglanidis   +3 more
wiley   +1 more source

Classification of tree species and standing dead trees in Boreal forests using UAV‐based RGB, multispectral, and LiDAR point clouds

Remote Sensing in Ecology and Conservation, EarlyView.
We evaluated single‐ and multi‐sensor UAV approaches for classifying tree species and standing dead trees in boreal forests, focusing on key biodiversity indicators such as European aspen. Using spectral and structural features extracted from RGB, multispectral (MSP), and LiDAR point clouds for 1,205 field‐measured trees, we compared classification ...
Anton Kuzmin, Lauri Korhonen, Topi Tanhuanpää, Mikko Kukkonen, Matti Maltamo, Timo Kumpula   +5 more
wiley   +1 more source