Results 241 to 250 of about 61,577 (309)

Highly efficient expression of DNA-peptide conjugates in growth-arrested cells. [PDF]

Nat Commun
Mohamedshah ZY, Chi CC, Tota EM, Komor AC, Devaraj NK.   +4 more
europepmc   +1 more source

Embedded CRISPRi Enhances Gene‐Silencing Efficiency in Drosophila

Advanced Science, Volume 13, Issue 31, 4 June 2026.
Current CRISPR interference (CRISPRi) technology in Drosophila has limited efficiency. This study introduces the emCRISPRi platform, which significantly enhances transcriptional silencing efficacy by embedding inhibitory domains within the dCas9 architecture.
Pengchong Fu, Xuedi Zhang, Ying Zhou, Jie Zheng, Angyang Sun, Kailong Zhuang, Weiwei Bao, Guanjun Gao   +7 more
wiley   +1 more source

The Hsp40 cochaperone DNAJC7 regulates polyglutamine aggregation and exhibits context-dependent effects on polyglycine aggregation. [PDF]

J Biol Chem
Ramani B, Ehsani K, Kampmann M.
europepmc   +1 more source

Directed Evolution Improves the Catalytic Efficiency of APEX2‐Mediated Proximity‐Dependent RNA Labeling

Advanced Science, Volume 13, Issue 32, 9 June 2026.
ABSTRACT Engineered ascorbate peroxidase APEX2 has been widely used for spatially restricted profiling of subcellular biomolecules, but its catalytic efficiency toward newly developed probes such as biotin‐aniline (Btn‐An) remains suboptimal. To overcome this limitation, we performed yeast surface display‐based directed evolution to enhance APEX2 ...
Gang Wang, Yi Li, Peiyuan Meng, Peng Zou
wiley   +1 more source

Intrinsically disordered regions stimulate concentration of small nucleolar ribonucleoproteins and formation of Cajal bodies and nucleoli. [PDF]

Genes Dev
Meznad K, Deogharia M, Wacheul L, Zorbas C, Lafontaine DLJ, Meier UT.   +5 more
europepmc   +1 more source

The Educational Exposome: A life‐course socioenvironmental framework for advancing Alzheimer's disease and ADRD research

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION The exposome encompasses all environmental exposures across the life course, yet educational environments, a critical socioenvironmental exposure, remain underexplored despite their role in cognitive aging and Alzheimer's disease and related dementias (AD/ADRD).
Kimson E. Johnson
wiley   +1 more source

Structural Dynamics of Peptiplexes Formed between Cationic Cell-Penetrating Peptides and DNA: A Comparative Study on TAT-HIV and NLS-SV40T. [PDF]

ACS Appl Bio Mater
de Mello LR, Siddiq IA, Garcia BBM, Hamley IW, Riske KA, Han SW, Tresset G, Lansac Y, Jang YH, da Silva ER.   +9 more
europepmc   +1 more source

Polyfluoralkylierte zellpenetrierende Peptid‐Additive verbessern die intrazelluläre Proteinaufnahme durch eine anhaltende und monomere Lipidinteraktion

Angewandte Chemie, Volume 138, Issue 23, 1 June 2026.
Wir berichten, dass nicht‐zytotoxische, polyfluoralkylierte zellpenetrierende Peptide (CPPs) als CPP‐Additive die intrazelluläre Proteinaufnahme signifikant verbessern, indem sie die Membranverweildauer der CPP‐Additive erhöhen. Durch die Kombination von biophysikalischen Experimenten und Molekulardynamiksimulationen zeigen wir zudem, dass die ...
Sarah Hansen, Hana Zupan, Ferhat Mutlu, Jan Vincent V. Arafiles, Rubén Cruz, Palina Dubatouka, Kenichi Ataka, Martin Lehmann, Bettina G. Keller, Joachim Heberle, Christian P. R. Hackenberger   +10 more
wiley   +1 more source

Nurse Leaders' Perceptions and Practices of E-Leadership: A Qualitative Study. [PDF]

J Nurs Manag
Numanovic V, Jalonen H, Lindell J.
europepmc   +1 more source