Results 271 to 280 of about 142,714 (313)

Increased CD8dim and Decreased CD8bright T Cells as Immunological Signature for Multibacilary Leprosy Patients

Immunology, Volume 175, Issue 4, Page 444-452, August 2025.
Leprosy, a chronic infectious disease caused by Mycobacterium leprae, manifests in a spectrum of clinical forms and severity. This study investigated the percentage of CD8+ T cells and their subpopulations (CD8bright and CD8dim T cells) in leprosy patients stratified by clinical forms, bacterial load, and age.
Yuri Scheidegger de Castro, Letícia Silva Nascimento, Juliana Azevedo da Silva, Rebeka da Conceição Souza, Gabriel Nogueira Araújo, Sandra Chalhub de Oliveira, Edilbert Pellegrini Nahn Junior, Alba Lucínia Peixoto‐Rangel   +7 more
wiley   +1 more source

Protein Carrier Adeno-Associated Virus. [PDF]

ACS Nano
Hoffmann MD, Sorensen RJ, Extross A, He Y, Schmidt D.   +4 more
europepmc   +1 more source

Characterization of a Novel <i>GATA4</i> Missense Variant p.Gly303Trp in a Family with Septal Heart Defects and Pulmonary Stenosis. [PDF]

Int J Mol Sci
Fabiani M, Zangheri C, Cima A, Monaco F, Ali' C, Barone MA, Viola A, Mesoraca A, Margiotti K, Giorlandino C.   +9 more
europepmc   +1 more source

The rhizobial type III effectors ErnA and Sup3 hijack the SUMOylation pathway to trigger nodule formation in Aeschynomene species

New Phytologist, Volume 247, Issue 4, Page 1826-1836, August 2025.
Summary Rhizobial type III effectors (T3Es) play a crucial role in the symbiotic relationship between rhizobia and legumes by manipulating host cellular processes to promote nodule formation. Previously, we identified two T3Es, ErnA and Sup3, that trigger nodulation in Aeschynomene spp. in the absence of Nod factors.
Fazal Haq, Alicia Camuel, Mélanie Carcagno, Emanuele G. Biondi, Valérie Pacquit, Laurent Deslandes, Eric Giraud, Peter Mergaert   +7 more
wiley   +1 more source

The Epstein-Barr virus EBNA1 protein binds to G-quadruplexes in its own mRNA hence controlling its expression and immune evasion of the virus. [PDF]

Nucleic Acids Res
Dinh VT, Loaëc N, Quillévéré A, Keruzoré M, Peynet A, Le Sénéchal R, Teulade-Fichou MP, Corcos L, Martins RP, Granzhan A, Blondel M.   +10 more
europepmc   +1 more source

Ontogeny and organ‐specific steroidal glycoside diversity is associated with differential expression of steroidal glycoside pathway genes in two Solanum dulcamara leaf chemotypes

Plant Biology, Volume 27, Issue 5, Page 651-668, August 2025.
Steroidal glycoside diversity among organs across ontogeny in relation to candidate gene expression in two Solanum dulcamara chemotypes. Abstract Solanaceous plants, such as Solanum dulcamara, produce steroidal glycosides (SGs). Leaf SG profiles vary among S.
R. A. Anaia, I. Chiocchio, R. Sontowski, B. Swinkels, F. Vergara, N. M. van Dam   +5 more
wiley   +1 more source

Inflammation-targeted nanomedicine prevents tumor metastasis following photodynamic therapy by reversing epithelial-mesenchymal transition and ROS-mediated immunosuppression. [PDF]

J Nanobiotechnology
Song Z, Sun Q, Yang W, Li Y, Hu C, Chen C, Liu K, Shen W, Yang Y, Yin D.   +9 more
europepmc   +1 more source

Peptidomimetics Targeting the Amyloidogenicity of Nucleophosmin 1 Mutations in Acute Myeloid Leukemia

ChemBioChem, Volume 26, Issue 14, July 18, 2025.
Previous studies reveal an unexpected tendency for amyloid aggregation in specific regions of the C‐terminal domain (CTD) of nucleophosmin 1 (NPM1), a nucleolar chaperone involved in acute myeloid leukemia (AML). Herein, several peptide analogs of NPM1264‐277 (amyloid core) with conservative substitutions are designed and evaluated through biophysical ...
Daniele Florio, Sara La Manna, Giada Raffaella Fiore, Valentina Roviello, Giuliano Castellano, Sossio Fabio Graziano, Anna Maria Malfitano, Daniela Marasco   +7 more
wiley   +1 more source

LSD1 is a targetable vulnerability in gastric cancer harboring TP53 frameshift mutations. [PDF]

Clin Epigenetics
Wang S, Yang C, Tang J, Wang K, Cheng H, Yao S, Huang Z, Fei B.   +7 more
europepmc   +1 more source

Light‐Activated Molecules Targeting G‐Quadruplex Nucleic Acids

Chemistry – A European Journal, Volume 31, Issue 39, July 11, 2025.
We shine a spotlight on the molecular recognition mechanisms and phototherapeutic potential of light‑activated compounds targeting G‑quadruplex nucleic acids, critically evaluating recent breakthroughs and charting the key challenges that must be overcome to drive this promising field forward.
Marta Dudek, Clément Cabanetos, Marco Deiana   +2 more
wiley   +1 more source