NM23-H1 Expression of Head and Neck Squamous Cell Carcinoma in Association With the Response to Irradiation [PDF]
Frontiers in Oncology, 2021 A low NM23-H1 expression in head and neck squamous cell carcinoma (HNSCC) was found to be associated with poor clinical outcome. Therefore, we investigated the role of NM23-H1 in the susceptibility of HNSCC cells to irradiation and its clinical ...
Yi-Fen Wang +10 more
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CTCF and EGR1 suppress breast cancer cell migration through transcriptional control of Nm23-H1 [PDF]
Scientific Reports, 2021 Tumor metastasis remains an obstacle in cancer treatment and is responsible for most cancer-related deaths. Nm23-H1 is one of the first metastasis suppressor proteins discovered with the ability to inhibit metastasis of many cancers including breast ...
Ka Ming Wong, Jiaxing Song, Yung H. Wong
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The Function of NM23-H1/NME1 and Its Homologs in Major Processes Linked to Metastasis. [PDF]
Pathol Oncol Res, 2020 International ...
Mátyási B +6 more
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The metastasis suppressor protein NM23-H1 modulates the PI3K-AKT axis through interaction with the p110α catalytic subunit [PDF]
Oncogenesis, 2021 The PI3K pathway is one of the most deregulated pathways in cancer, which is predominantly due to gain of function mutations or altered expression of the PI3KCA gene. This is codified by what is seen for the class I PI3K catalytic subunit p110α, a common
Francesco Paolo Pennino +3 more
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Nm23-H1 is involved in the repair of ionizing radiation-induced DNA double-strand breaks in the A549 lung cancer cell line [PDF]
BMC Cancer, 2018 Background Although originally identified as a putative metastasis suppressor, increasing studies have confirmed a possible role for Nm23-H1 in DNA repair, through the base excision repair and nucleotide excision repair pathways.
Ya Sheng +7 more
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Nm23‐H1 inhibits lung cancer bone‐specific metastasis by upregulating miR‐660‐5p targeted SMARCA5 [PDF]
Thoracic Cancer, 2020 Background Nm23‐H1 gene has been found to be an inhibitor of tumor metastasis in lung cancer. MicroRNAs (miRNAs) play key roles in tumor metastasis through multiple signaling pathways.
Cheng Ai +8 more
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Transcription analysis of TIMP-1 and NM23-h1 genes in glioma cell invasion Análise transcricional dos genes TIMP-1 e NM23-H1 na invasão celular em astrocitoma difuso e glioblastoma multiforme [PDF]
Arquivos de Neuro-Psiquiatria, 2006 PURPOSE: To evaluate using transcription analysis the presence and importance of two genes: NM23-H1 and TIMP-1 on control of tumor cell invasion in diffuse astrocytomas (WHO II) and glioblastoma multiforme (WHO IV). METHOD: Northern blot analysis of NM23-
José Augusto Nasser +4 more
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Nm23-H1 activator phenylbutenoid dimer exerts cytotoxic effects on metastatic breast cancer cells by inducing mitochondrial dysfunction only under glucose starvation [PDF]
Scientific Reports, 2021 Mitochondrial oxidative phosphorylation (OXPHOS) has become an attractive target in anti-cancer studies in recent years. In this study, we found that a small molecule phenylbutenoid dimer NMac1 (Nm23-H1 activator 1), (±)-trans-3-(3,4-dimethoxyphenyl)-4-[(
Bokyung Kim +7 more
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Effect of Nm23-H1 Nuclear Localization on Proliferation of Human Lung Adenocarcinoma Cell Line A549 [PDF]
Chinese Journal of Lung Cancer, 2017 Background and objective Recent studies have indicated that Nm23-H1 is found in the nucleus, but previous studies have been based on the overexpression or suppression of Nm23-H1 in the cytoplasm. Due to the lacking nuclear localization signal of Nm23-H1,
Ya SHENG +5 more
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Nm23-H1-stabilized hnRNPA2/B1 promotes internal ribosomal entry site (IRES)-mediated translation of Sp1 in the lung cancer progression [PDF]
Scientific Reports, 2017 Our recent studies have indicated that specificity protein-1 (Sp1) accumulates substantially in the early stage of lung cancer but is partially decreased in the late stages, which is an important factor in the progression of the cancer. In this study, we
Chia-Yang Hung +6 more
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