Results 101 to 110 of about 3,123 (185)

PuF, An Antimetastatic and Developmental Signaling Protein, Interacts with the Alzheimer’s Amyloid-β Precursor Protein via a Tissue-Specific Proximal Regulatory Element (PRE) [PDF]

open access: yes, 2013
Background: Alzheimer’s disease (AD) is intimately tied to amyloid-β (Aβ) peptide. Extraneuronal brain plaques consisting primarily of Aβ aggregates are a hallmark of AD. Intraneuronal Aβ subunits are strongly implicated in disease progression.
Ge, Yuan-Wen   +3 more
core   +3 more sources

NDP Kinase Moves into Developing Primary Cilia [PDF]

open access: yes, 2004
Inmunofluorescence staining of murine NIH3T3 fibroblasts grown at high density shows that conventional nucleoside diphosphate (NDP) kinases A and B localize to a sensory organelle, the primary cilium.
Gallagher, Betty C.   +3 more
core   +2 more sources

The SET complex acts as a barrier to autointegration of HIV-1.

open access: yesPLoS Pathogens, 2009
Retroviruses and retrotransposons are vulnerable to a suicidal pathway known as autointegration, which occurs when the 3'-ends of the reverse transcript are activated by integrase and then attack sites within the viral DNA.
Nan Yan   +4 more
doaj   +1 more source

Aldehyde dehydrogenase 1A1 and gelsolin identified as novel invasion-modulating factors in conditioned medium of pancreatic cancer cells [PDF]

open access: yes, 2008
Conditioned medium (CM) from clonal sub-populations of the pancreatic cancer cell line, MiaPaCa-2 with differing invasive abilities, were examined for their effect on in vitro invasion.
Alban   +51 more
core   +3 more sources

Molecular prognostic factors in early-stage cervical adenocarcinoma

open access: yesPolish Journal of Pathology, 2018
Within the past years the proportion of cervical adenocarcinomas has increased, however, there is a shortage of data regarding immunohistochemical and molecular features and their prognostic relevance in early-stage cervical adenocarcinoma (esCAC).
Maciej Bodzek   +8 more
doaj   +1 more source

Effect of Inhibition of the Lysophosphatidic Acid Receptor 1 on Metastasis and Metastatic Dormancy in Breast Cancer [PDF]

open access: yes, 2017
Background Previous studies identified the human nonmetastatic gene 23 (NME1, hereafter Nm23-H1) as the first metastasis suppressor gene. An inverse relationship between Nm23-H1 and expression of lysophosphatidic acid receptor 1 gene (LPAR1, also known ...
Albaugh, Mary   +11 more
core  

ARF6-dependent regulation of P2Y receptor traffic and function in human platelets.

open access: yesPLoS ONE, 2012
Adenosine diphosphate (ADP) is a critical regulator of platelet activation, mediating its actions through two G protein-coupled receptors, the P2Y(1) and P2Y(12) purinoceptors. Recently, we demonstrated that P2Y(1) and P2Y(12) purinoceptor activities are
Venkateswarlu Kanamarlapudi   +4 more
doaj   +1 more source

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