Results 161 to 170 of about 3,123 (185)

Structure of Nm23-H1 under oxidative conditions

Acta Crystallographica Section D Biological Crystallography, 2013
Nm23-H1/NDPK-A, a tumour metastasis suppressor, is a multifunctional housekeeping enzyme with nucleoside diphosphate kinase activity. Hexameric Nm23-H1 is required for suppression of tumour metastasis and it is dissociated into dimers under oxidative conditions. Here, the crystal structure of oxidized Nm23-H1 is presented.
Mi-Sun, Kim, Jaeho, Jeong, Jihye, Jeong, Dong-Hae, Shin, Kong-Joo, Lee   +4 more
openaire   +2 more sources

Expression of nm23-H1 in uveal melanoma

Melanoma Research, 2007
Uveal melanoma (UM) is the most common malignant intraocular tumor in adults. Despite the high accuracy of clinical diagnosis and advances in local treatment, more than 50% of UM patients develop metastasis within 10 years of initial diagnosis. NM23 is one of the human metastasis suppressor genes.
Silvin, Bakalian, Jean Claude, Marshall, Dana, Faingold, Patrick, Logan, Emilia, Antecka, Miguel N, Burnier   +5 more
openaire   +2 more sources

Regulators affecting the metastasis suppressor activity of Nm23-H1

Molecular and Cellular Biochemistry, 2009
Nm23-H1 encodes nucleoside diphosphate kinase A (NDPK-A) and is known to have a metastasis suppressive activity in many tumor cells. However, it has many other functions as well. Recent studies have shown that the interacting proteins with Nm23-H1 which mediate the cell proliferation, may act as modulators of the metastasis suppressor activity.
Hag Dong, Kim, Buhyun, Youn, Tae-Sung, Kim, Sang-Hwa, Kim, Hyun-Seock, Shin, Joon, Kim   +5 more
openaire   +2 more sources

Prognostic implication of nm23-H1 expression in colorectal carcinomas

Pathology, 2002
Expression of nm23 has been identified as a potential metastatic suppressor. In this study, nm23-H1 expression, clinicopathological parameters and influences on clinical outcomes were investigated in colorectal carcinoma patients.Immunostaining was performed on 185 colorectal carcinomas using a polyclonal anti-nm23-H1 antibody.The nm23-H1 ...
Akyurek, NALAN, Yamac, D, Gunel, N, Dursun, A   +3 more
openaire   +3 more sources

Nm23-H1 immunohistochemical expression in multisteps of cervical carcinogenesis

International Journal of Gynecological Cancer, 2003
To evaluate the expression of nm23-H1 protein in normal, precancerous, and cancerous tissues of the uterine cervix and its role in cervical carcinogenesis, metastasis and recurrence, 82 cervical specimens, including 30 squamous cell carcinomas (SCC), 19 high- and 13 low-grade squamous intraepithelial lesions (HSILs and LSILs) and 20 normal samples ...
P-H, Wang, H, Chang, J-L, Ko, L-Y, Lin
openaire   +2 more sources

nm23-H1 protein immunohistochemical expression in human breast cancer

Oncology Reports, 1996
A series of 76 patients undergoing surgery for primary breast carcinoma has been prospectively studied in order to evaluate the relative weight of nm23-H1 protein expression in disease-free survival. Expression of nm23 protein was immunohistochemically assessed. In all, 39% (29/74) of the turners showed positive staining for nm23-H1 protein expression.
A, Russo, V, Bazan, V, Morello, C, Valli, E, Giarnieri, G, Dardanoni, S, Cucciarre, I, Carreca, P, Bazan, R, Tomasino, A, Vecchione   +10 more
openaire   +2 more sources

nm23-H1 Expression in non-Hodgkin and Hodgkin Lymphomas

Applied Immunohistochemistry & Molecular Morphology, 2008
We assessed for nm23-H1 expression in 262 lymphoid neoplasms including 191 B-cell non-Hodgkin lymphoma (NHL), 54 T-cell NHL, and 17 Hodgkin lymphoma (HL). We used a monoclonal anti-nm23-H1 antibody, routinely processed tissue, and immunohistochemical methods.
Sema, Bircan, Kedar V, Inamdar, George Z, Rassidakis, L J, Medeiros   +3 more
openaire   +2 more sources

The multiple regulation of metastasis suppressor NM23-H1 in cancer

Life Sciences, 2021
Metastasis is one of the leading causes of mortality in cancer patients. As the firstly identified metastasis suppressor, NM23-H1 has been endowed with expectation as a potent target in metastatic cancer therapy during the past decades. However, many challenges impede its clinical use.
Liting, Yu, Xindong, Wang, Wanheng, Zhang, Eshan, Khan, Chenyu, Lin, Changying, Guo   +5 more
openaire   +2 more sources

Nm23‐H1 promotes adhesion of CAL 27 cells in vitro

Molecular Carcinogenesis, 2009
Abstractnm23‐H1 was found to diminish metastatic potential of carcinoma cell lines and therefore was placed in the group of metastatic suppressor genes. Its protein product has a function of a nucleoside diphosphate kinase (NDPK) as well as protein kinase and nuclease. Though it was found that Nm23‐H1 is involved in many cellular processes, it is still
Bago, Ružica, Pavelić, Jasminka, Herak Bosnar, Maja, Maravić Vlahoviček, Gordana   +3 more
openaire   +3 more sources

Squamous cell lung carcinomas: the role of nm23-H1 gene

Journal of Molecular Medicine, 1997
This analysis of 32 pairs of human squamous cell lung carcinomas and normal matched control DNA demonstrates that loss of heterozygosity (LOH) is infrequent at the nm23-H1 locus, affecting only 2 of the 18 informative cases. Both LOH cases were in the tumor stage IIIA. One tumor was of poor and the other of moderate histological grade.
Pavelić, Krešimir, Križanac, Šimun, Herak Bosnar, Maja, Pavelić, Jasminka, Slobodnjak, Zoran   +4 more
openaire   +3 more sources