NM23-H1: a Metastasis-Associated Gene
Taiwanese Journal of Obstetrics & Gynecology, 2006 The protein product of nm23-H1 gene has activity of nucleoside diphosphate (NDP) kinase, which catalyzes the phosphorylation of nucleoside diphosphates to the corresponding nucleoside triphosphates.
Yi-Torng Tee +4 more
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Nm23-H1 Regulates Glucose-Stimulated Insulin Secretion in Pancreatic β-Cells via Arf6-Rac1 Signaling Axis [PDF]
Cellular Physiology and Biochemistry, 2013 Background: A growing body of evidence implicates novel roles for nm23-like proteins in the regulation of cellular functions. However, roles of these proteins in islet function and glucose-stimulated insulin secretion (GSIS) remain largely unknown ...
Rajakrishnan Veluthakal +2 more
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Extracellular NM23 Protein as a Therapeutic Target for Hematologic Malignancies [PDF]
Advances in Hematology, 2012 An elevated serum level of NM23-H1 protein is a poor prognostic factor in patients with various hematologic malignancies. The extracellular NM23-H1 protein promotes the in vitro growth and survival of acute myelogenous leukemia (AML) cells and inversely ...
Junko Okabe-Kado +2 more
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Comparative Proteomics Study on Human High-metastatic Large Cell Lung Cancer Cell Lines Before and After Transfecting with nm23-H1 Gene [PDF]
Chinese Journal of Lung Cancer, 2010 Background and objective As a tumor metastasis suppressor gene, the functions of nm23-H1 gene are still unclear. The aim of this study is to better understand the mechanism of lung cancer metastasis and to find new biomarkers for early diagnosis and new ...
Liwei GAO +6 more
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Multiple functions of Nm23-H1 are regulated by oxido-reduction system. [PDF]
PLoS ONE, 2009 Nucleoside diphosphate kinase (NDPK, Nm23), a housekeeping enzyme, is known to be a multifunctional protein, acting as a metastasis suppressor, transactivation activity on c-myc, and regulating endocytosis.
Eunsun Lee +5 more
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Construction and Expression of nm23-H1 Gene with Different Enzyme Activities and Resistant Specific shRNA in Eukaryotic Expression Vector [PDF]
Chinese Journal of Lung Cancer, 2014 Background and objective It has been proven that nm23-H1 gene was a tumor metastatic suppressor gene. However, it’s molecular mechanism of suppressing metastasis remains unexplored.
Zhansheng LU +4 more
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Prune cAMP phosphodiesterase binds nm23-H1 and promotes cancer metastasis [PDF]
Cancer Cell, 2004 We identify a new enzymatic activity underlying metastasis in breast cancer and describe its susceptibility to therapeutic inhibition. We show that human prune (h-prune), a phosphoesterase DHH family appertaining protein, has a hitherto unrecognized ...
Aglio V +10 more
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MUC1* ligand, NM23-H1, is a novel growth factor that maintains human stem cells in a more naïve state. [PDF]
PLoS ONE, 2013 We report that a single growth factor, NM23-H1, enables serial passaging of both human ES and iPS cells in the absence of feeder cells, their conditioned media or bFGF in a fully defined xeno-free media on a novel defined, xeno-free surface.
Benoit J Smagghe +12 more
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The NM23-H1/H2 homolog NDK-1 is required for full activation of Ras signaling in C. elegans. [PDF]
Development, 2013 The group I members of the Nm23 (non-metastatic) gene family encode nucleoside diphosphate kinases (NDPKs) that have been implicated in the regulation of cell migration, proliferation and differentiation.
Masoudi N +8 more
europepmc +3 more sources
NDK-1, the homolog of NM23-H1/H2 regulates cell migration and apoptotic engulfment in C. elegans. [PDF]
PLoS ONE, 2014 Abnormal regulation of cell migration and altered rearrangement of cytoskeleton are characteristic of metastatic cells. The first described suppressor of metastatic processes is NM23-H1, which displays NDPK (nucleoside-diphosphate kinase) activity.
Luca Fancsalszky +11 more
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