Results 21 to 30 of about 3,123 (185)

Prognostic Value of NME1 (NM23-H1) in Patients with Digestive System Neoplasms: A Systematic Review and Meta-Analysis. [PDF]

PLoS ONE, 2016
ObjectiveThere is a heated debate on whether the prognostic value of NME1 is favorable or unfavorable. Thus, we carried out a meta-analysis to evaluate the relationship between NME1 expression and the prognosis of patients with digestive system neoplasms.
Wei Han, Chun-Tao Shi, Fei-Yun Cao, Fang Cao, Min-Bin Chen, Rong-Zhu Lu, Hua-Bing Wang, Min Yu, Da-Wei He, Qing-Hua Wang, Jie-Feng Wang, Xuan-Xuan Xu, Hou-Zhong Ding   +12 more
doaj   +2 more sources

The Study on the Phosphorylation Activity of Mutant nm23-H1

Chinese Journal of Lung Cancer, 2009
Background and objective The Phosphorylation is the key activity of nm23-H1. The aim of this study is to explore the effect of different amino acid mutation on the phosphorylation status of nm23-H1.
Xueqin YANG, Li MA, Daxing ZHU, Dong WANG, Ge WANG, Qinghua ZHOU   +5 more
doaj   +2 more sources

nm23-H1 mutation in neuroblastoma [PDF]

Nature, 1994
Peer Reviewed ; http://deepblue.lib.umich.edu/bitstream/2027.42/62612/1/370335a0 ...
Chang, C. L., Zhu, X. X., Thoraval, D. H., Ungar, David R., Rawwas, J., Hora, Nivedita, Strahler, John R., Hanash, Samir M., Radany, Eric H.   +8 more
openaire   +3 more sources

nm23‐H1 protein immunoreactivity in laryngeal carcinoma [PDF]

Cancer, 1996
The nm23-H1 gene encodes a 17-kilodalton cytoplasmic and nuclear protein that has recently been shown to be reduced in a number of human carcinomas including breast, colorectal, lung, gallbladder, and biliary tract carcinomas. This study examines the immunohistochemical staining characteristics of the nm23-H1 protein in human laryngeal carcinomas and ...
C S, Lee, A, Redshaw, G, Boag
openaire   +2 more sources

Mass spectrometry detection of histidine phosphorylation on NM23-H1. [PDF]

J Proteome Res, 2011
Phosphorylation is a ubiquitous protein post-translational modification that is intimately involved in most aspects of cellular regulation. Currently, most proteomic analyses are performed with phosphorylation searches for serine, threonine, and tyrosine modifications, as the phosphorylated residues of histidine and aspartic acid are acid labile and ...
Lapek JD, Tombline G, Friedman AE.
europepmc   +4 more sources

The emerging landscape of eukaryotic polyphosphatases

FEBS Letters, Volume 597, Issue 11, Page 1447-1461, June 2023., 2023
Polyphosphatase enzymes in eukaryotic cells degrade polyphosphate (polyP) chains starting at the end of the chain (exopolyphosphatases), or by cleaving the chain internally to generate two smaller chains (endopolyphosphatases). While there are similarities in proposed polyphosphatases in yeast and mammalian systems, the yeast enzymes are better ...
Liam McCarthy, Michael Downey
wiley   +1 more source

Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications

MedComm, Volume 4, Issue 3, June 2023., 2023
The reversible and irreversible protein posttranslational modifications, such as acetylation, methylation, phosphorylation, ubiquitination, glycosylation, SUMOylation, and redox modifications, are essential regulators in organisms and cells. This work systematically summarizes the features, regulatory mechanisms, substrates, functions, and related ...
Qian Zhong, Xina Xiao, Yijie Qiu, Zhiqiang Xu, Chunyu Chen, Baochen Chong, Xinjun Zhao, Shan Hai, Shuangqing Li, Zhenmei An, Lunzhi Dai   +10 more
wiley   +1 more source

Human Endonuclease ANKLE1 Localizes at the Midbody and Processes Chromatin Bridges to Prevent DNA Damage and cGAS‐STING Activation

Advanced Science, Volume 10, Issue 12, April 26, 2023., 2023
Persistent chromatin bridges trapped in the spindle midzone can be broken by actomyosin forces during cytokinesis. This study shows that ANKLE1 is a midbody‐tethered endonuclease that acts directly on DNA bridges trapped in the midbody to prevent the extensive formation of micronuclei and cytosolic DNA. Therefore, ANKLE1 prevents genome instability and
Huadong Jiang, Nannan Kong, Zeyuan Liu, Stephen C. West, Ying Wai Chan   +4 more
wiley   +1 more source

Regulation of the metastasis suppressor Nm23-H1 by tumor viruses. [PDF]

Naunyn Schmiedebergs Arch Pharmacol, 2015
Metastasis is the most common cause of cancer mortality. To increase the survival of patients, it is necessary to develop more effective methods for treating as well as preventing metastatic diseases. Recent advancement of knowledge in cancer metastasis provides the basis for development of targeted molecular therapeutics aimed at the tumor cell or its
Banerjee S, Jha HC, Robertson ES.
europepmc   +4 more sources

Based on Network Pharmacology‐Quercetin, a Component of Fuzheng Yiliu Decoction Suppressed Prostate Cancer by Regulating PI3K/AKT Pathway

Andrologia, Volume 2023, Issue 1, 2023., 2023
Background. Fuzheng Yiliu decoction (FZYLD) was a traditional prescription with an antitumor effect. We aimed to explore the antitumor effect of FZYLD and its active ingredient, quercetin, on prostate cancer (PCa). Methods. The effective components and potential targets of FZYLD were obtained from the TCMSP, Herb, and Batman databases. The relationship
Wei Fu, Lei Xu, Yingwen Chen, Xuyao Lin, Gaoli Hao, Chenxi Li, Hongying Li, Zezheng Zhang, Shuchao Chen, Xujun You, Qixin Li, Shuiqiao Yuan   +11 more
wiley   +1 more source