Results 31 to 40 of about 3,123 (185)

Structural and molecular characterization of paraventricular thalamic glucokinase‐expressing neuronal circuits in the mouse

Journal of Comparative Neurology, Volume 530, Issue 11, Page 1773-1949, August 2022., 2022
By using a genetically modified mouse model and viral tracing approaches, we mapped both the anterograde and the retrograde projections of a subpopulation of neurons in the anterior paraventricular thalamic nucleus, molecularly defined by the expression of glucokinase (GckaPVT).
Sevasti Gaspari, Simon Quenneville, Ana Rodriguez Sanchez‐Archidona, Bernard Thorens, Sophie Croizier   +4 more
wiley   +1 more source

Impact of Phytochemicals on PPAR Receptors: Implications for Disease Treatments

PPAR Research, Volume 2022, Issue 1, 2022., 2022
Peroxisome proliferator‐activated receptors (PPARs) are members of the ligand‐dependent nuclear receptor family. PPARs have attracted wide attention as pharmacologic mediators to manage multiple diseases and their underlying signaling targets. They mediate a broad range of specific biological activities and multiple organ toxicity, including cellular ...
Ayesheh Enayati, Mobina Ghojoghnejad, Basil D. Roufogalis, Seyed Adel Maollem, Amirhossein Sahebkar, John P. Vanden Heuvel   +5 more
wiley   +1 more source

Potential Functional Food Products and Molecular Mechanisms of Portulaca Oleracea L. on Anticancer Activity: A Review

Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022
Portulaca oleracea Linn. (P. oleracea L.) has recently gained attention as a functional food due to the chemical composition of this plant regarding bioactive compounds. The special attention to the use of P. oleracea as an ingredient in functional food products is also due to the promotion of sustainable food.
Pâmela Gomes de Souza, Amauri Rosenthal, Ellen Mayra Menezes Ayres, Anderson Junger Teodoro, Alexandros Georgakilas   +4 more
wiley   +1 more source

Necdin: A purposive integrator of molecular interaction networks for mammalian neuron vitality

Genes to Cells, Volume 26, Issue 9, Page 641-683, September 2021., 2021
Necdin interacts with major regulatory proteins such as E2F1, p53, neurotrophin receptors (TrkA, p75NTR), Sirt1 and PGC‐1α, which serve as highly connected hubs of protein–protein interaction networks for mitosis, apoptosis, differentiation, neuroprotection and energy homeostasis. By integrating these networks, necdin promotes the vitality of mammalian
Kazuaki Yoshikawa
wiley   +1 more source

miR‐137 Inhibition of the Invasion, Metastasis, and Epithelial‐Mesenchymal Transition of Nasopharyngeal Cancer by Regulating KDM1A

Journal of Oncology, Volume 2021, Issue 1, 2021., 2021
One of the most frequent malignancies in the head and neck is nasopharyngeal carcinoma (NPC). MicroRNAs, a kind of tiny noncoding RNA molecule, have been used as negative regulators in different types of cancer therapy in recent decades by downregulating their targets.
Han-qiang Lu, Run-kun Wang, Hui-rong Wang, Guang-quan Zhou, Yan-shu Zhang, Ashok Pandurangan   +5 more
wiley   +1 more source

Transcriptome Analysis Reveals the Genes Involved in Growth and Metabolism in Muscovy Ducks

BioMed Research International, Volume 2021, Issue 1, 2021., 2021
Muscovy ducks are among the best meat ducks in the world. The objective of this study was to identify genes related to growth metabolism through transcriptome analysis of the ileal tissue of Muscovy ducks. Duck ileum samples with the highest (H group, n = 5) and lowest (L group, n = 5) body weight were selected from two hundred 70‐day‐old Muscovy ducks
Xingxin Wang, Yingping Xiao, Hua Yang, Lizhi Lu, Xiuting Liu, Wentao Lyu, Yong Feng   +6 more
wiley   +1 more source

The Nm23-H1 metastasis suppressor as a translational target. [PDF]

Eur J Cancer, 2010
Nm23 was the first of what has become a field of over 20 known metastasis suppressor genes (MSGs). Since the discovery of Nm23 in 1988, a variety of mechanisms have been attributed to its activity, including a histidine kinase activity, binding of other proteins to regulate metastatic formation, and altered gene expression downstream of Nm23.
Marshall JC, Collins J, Marino N, Steeg P.   +3 more
europepmc   +4 more sources

The metastasis suppressor Nm23 as a modulator of Ras/ERK signaling. [PDF]

, 2014
NM23-H1 (also known as NME1) was the first identified metastasis suppressor, which displays a nucleoside diphosphate kinase (NDPK) and histidine protein kinase activity.
Takács-Vellai, Krisztina
core   +1 more source

Clinical-translational approaches to the Nm23-H1 metastasis suppressor. [PDF]

Clin Cancer Res, 2008
AbstractNm23-H1 significantly reduces metastasis without effects on primary tumor size and was the first discovered metastasis suppressor gene. At least three mechanisms are thought to contribute to the metastasis-suppressive effect of Nm23-H1: (a) its histidine kinase activity toward ATP-citrate lyase, aldolase C, and the kinase suppressor of ras ...
Steeg PS, Horak CE, Miller KD.
europepmc   +4 more sources

TREX1 DNA exonuclease deficiency, accumulation of single stranded DNA and complex human genetic disorders [PDF]

, 2008
Aicardi-Goutieres syndrome (AGS) is an unusual condition that clinically mimics a congenital viral infection. Several genes have recently been implicated in the aetiology of this disorder. One of these genes encodes the DNA exonuclease TREX1. Recent work
Aicardi, Akira, Alderton, Alderton, Bartek, Bartkova, Brennan, Brucet, Chen, Chowdhury, Crow, Crow, de Silva, DiTullio, Driscoll, Gasser, Griffith, Griffiths, Höss, Jazayeri, Kawai, Lee-Kirsch, Lee-Kirsch, Lieberman, Lieberman, Lindahl, Lindahl, Liu, Liu, Liu, Mark O’Driscoll, Martinvalet, Mazur, Mazur, Morita, Napirei, O’Driscoll, O’Driscoll, Qiu, Raulet, Rhodes, Rice, Richards, Shevelev, Stiff, Stiff, Takaoka, Tran, Tsukumo, Vyse, Walport, Yang, Yasutomo, Zou, Zou   +54 more
core   +1 more source