Results 51 to 60 of about 3,123 (185)

17beta-hydroxysteroid dehydrogenase type 1 modulates breast cancer protein profile and impacts cell migration [PDF]

, 2012
INTRODUCTION: Human 17beta-hydroxysteroid dehydrogenase type 1 (17β-HSD1) is a steroid-converting enzyme that has long been known to play critical roles in estradiol synthesis and more recently in dihydrotestosterone (DHT) inactivation, showing a dual ...
François Houle, Jacques Huot, Juliette A Aka, Mouna Zerradi, Sheng-Xiang Lin   +4 more
core   +1 more source

Pathogen and human NDPK-proteins promote AML cell survival via monocyte NLRP3-inflammasome activation.

PLoS ONE, 2023
A history of infection has been linked with increased risk of acute myeloid leukaemia (AML) and related myelodysplastic syndromes (MDS). Furthermore, AML and MDS patients suffer frequent infections because of disease-related impaired immunity.
Sandro Trova, Fei Lin, Santosh Lomada, Matthew Fenton, Bhavini Chauhan, Alexandra Adams, Avani Puri, Alessandro Di Maio, Thomas Wieland, Daniel Sewell, Kirstin Dick, Daniel Wiseman, Deepti P Wilks, Margaret Goodall, Mark T Drayson, Farhat L Khanim, Christopher M Bunce   +16 more
doaj   +1 more source

Strand-specific miR-28-5p and miR-28-3p have distinct effects in colorectal cancer cells [PDF]

, 2012
The authors thank Sue Moreau from the Department of Scientific Publications at The University of Texas MD Anderson Cancer Center for English language editing of the manuscript.
Almeida, Arber, Arber, Björnsson, Boissan, Boland, Bustin, Calin, Chaitanya, Cristina Ivan, Croce, Diehl, Francesca Fanini, Fu, Galluzzi, George A. Calin, Giovanni Lanza, Girardot, Gottardo, Griffiths-Jones, Ivan Vannini, Jemal, Jemal, Jiang, Kanai, Krosl, Lea, Lee, Lee, Lefever, Lianchun Xiao, Lizhi Zeng, López, Malzkorn, Maria I. Almeida, Marshall, Milena S. Nicoloso, Muller Fabbri, Palakurthy, Patrick A. Zweidler–McKay, Pfaffl, Rajput, Riccardo Spizzo, Roberta Gafà, Romano, Rui M. Reis, Schmittgen, Spizzo, Steeg, Steeg, Suzuki, Volinia, Wu, Xinna Zhang, Yang   +54 more
core   +1 more source

Nm23-H1: Genetic Alterations and Expression Patterns in Tumor Metastasis [PDF]

The American Journal of Human Genetics, 1998
Nm23-H1 originally was discovered on the basis of its reduced RNA expression in very highly metastatic murine melanoma cell lines. Since that time, it has been shown to reduce the metastatic potential of highly aggressive tumors and to be an indicator of poor patient prognosis in many cancer types. Although LOH of NME1 is prevalent in many tumors, this
Hartsough, Melanie T., Steeg, Patricia S.   +1 more
openaire   +2 more sources

Nm23-H1 suppresses hepatocarcinoma cell adhesion and migration on fibronectin by modulating glycosylation of integrin beta1

Journal of Experimental & Clinical Cancer Research, 2010
Background Nm23 gene was isolated as a metastatic suppressor gene. The antimetastatic effect of Nm23 has been an enigma for more than 10 years. Little is known about its molecular mechanisms.
He Min, Xu Boying, She Shangyang, Lan Xiuwan, Wang Qiuyan   +4 more
doaj   +1 more source

Cell Signaling and Differential Protein Expression in Neuronal Differentiation of Bone Marrow Mesenchymal Stem Cells with Hypermethylated Salvador/Warts/Hippo (SWH) Pathway Genes. [PDF]

PLoS ONE, 2015
Human mesenchymal stem cells (MSCs) modified by targeting DNA hypermethylation of genes in the Salvador/Warts/Hippo pathway were induced to differentiate into neuronal cells in vitro. The differentiated cells secreted a significant level of brain-derived
Hui-Hung Tzeng, Chi-Hung Hsu, Ting-Hao Chung, Wen-Chien Lee, Chi-Hsien Lin, Wan-Chen Wang, Chen-Yu Hsiao, Yu-Wei Leu, Tzu-Hsien Wang   +8 more
doaj   +1 more source

The Metastasis Suppressor NM23-H1 Possesses 3′-5′ Exonuclease Activity [PDF]

Journal of Biological Chemistry, 2004
NM23-H1 belongs to a family of eight gene products in humans that have been implicated in cellular differentiation and development, as well as oncogenesis and tumor metastasis. We have defined NM23-H1 biochemically as a 3'-5' exonuclease by virtue of its ability in stoichiometric amounts to excise single nucleotides in a stepwise manner from the 3 ...
Deqin, Ma, Joseph R, McCorkle, David M, Kaetzel   +2 more
openaire   +2 more sources

Engineered CAR‐T–Derived Exosomes Co‐Delivering miR‐145 and Cytotoxic Proteins for Targeted Solid Tumour Therapy

Journal of Extracellular Vesicles, Volume 15, Issue 3, March 2026.
ABSTRACT Chimeric antigen receptor T cell (CAR‐T) therapy has demonstrated remarkable efficacy in haematologic malignancies but remains constrained in solid tumours due to limited tumour penetration, immunosuppressive microenvironments and the risk of cytokine release syndrome (CRS).
Ruyue Yang, Haitao Wang, Guidan Wang, Gankun Yuan, Zhaoyi Wei, Junling An, Dong Hu, Wenjing Wen, Shegan Gao, Yuan Wan, Gaofeng Liang   +10 more
wiley   +1 more source

Nm23-H1 can induce cell cycle arrest and apoptosis in B cells [PDF]

, 2010
Nm23-H1 is a well-known tumor metastasis suppressor, which functions as a nucleoside-diphosphate kinase converting nucleoside diphosphates to nucleoside triphosphates with an expense of ATP.
Choudhuri, Tathagata, Kaul, Rajeev, Kumar, Pankaj, Mohanty, Suchitra, Murakami, Masanao, Robertson, Erle S., Sahu, Sushil K., Verma, Subhash C.   +7 more
core   +2 more sources

NSUN6 Maintains BMPER Stability in an m5C‐Dependent Manner to Suppress Cell Proliferation and Migration in Hepatocellular Carcinoma

Biology of the Cell, Volume 117, Issue 7, July 2025.
In hepatocellular carcinoma (HCC), the methyltransferase NSUN6 catalyzes m⁵C modification of BMPER mRNA, enhancing its stability and elevating BMPER protein expression. This NSUN6‐BMPER axis suppresses HCC progression by inhibiting tumor cell proliferation/migration while correlating with improved patient prognosis, establishing RNA epigenetic ...
Chunlin Liu, Yumin Wu, Ying Wu, Weizhi Luo, Yuefei Hong, Leichang Jiang, Senrui Wang, Duanming Du   +7 more
wiley   +1 more source