Results 61 to 70 of about 3,123 (185)

A competitive cell-permeable peptide impairs Nme-1 (NDPK-A) and Prune-1 interaction: therapeutic applications in cancer. [PDF]

, 2018
The understanding of protein–protein interactions is crucial in order to generate a second level of functional genomic analysis in human disease. Within a cellular microenvironment, protein–protein interactions generate new functions that can be defined ...
Asadzadeh, F., Ferrucci, V., Pennino, F. P., Siciliano, R., Zollo, M   +4 more
core   +1 more source

ERK1/2 mitogen‐activated protein kinase dimerization is essential for the regulation of cell motility

Molecular Oncology, Volume 19, Issue 2, Page 452-473, February 2025.
In mammary tumor cells, ERK dimerization is both necessary and sufficient for inducing cellular migration. The scaffold protein KSR1 is a critical element for endowing external agonists, acting through tyrosine kinase receptors, with the capacity to induce ERK dimerization and, subsequently, unleashing cellular motion, as a consequence of which tumor ...
Dalia de la Fuente‐Vivas, Vincenzo Cappitelli, Rocío García‐Gómez, Sara Valero‐Díaz, Camilla Amato, Javier Rodriguéz, Santiago Duro‐Sánchez, Alexander von Kriegsheim, Michael Grusch, José Lozano, Joaquín Arribas, Berta Casar, Piero Crespo   +12 more
wiley   +1 more source

New roles for the major human 3\u27–5\u27 exonuclease TREX1 in human disease [PDF]

, 2008
Aicardi-Goutières syndrome (AGS), Systemic Lupus Erythematosus (SLE), Familial Chilblain Lupus (FCL) and Retinal Vasculopathy and Cerebral Leukodystrophy (RVCL) {a new term encompassing three independently described conditions with a common etiology ...
Atkinson, John P, Kavanagh, David, Kothari, Parul H, Liszewski, M Kathryn, Richards, Anna, Shaikh, Aisha, Spitzer, Dirk   +6 more
core   +4 more sources

Lycopene in Combination With Sorafenib Additively Inhibits Tumor Metastasis in Mice Xenografted With Lewis Lung Carcinoma Cells

Frontiers in Nutrition, 2022
Cancer metastasis is the leading cause of death in cancer patients. However, it is unclear whether lycopene can act as an adjuvant to increase the anti-metastatic activity of anticancer drugs.
Ya-Ping Chan, Cheng-Hung Chuang, Inn Lee, Nae-Cherng Yang, Nae-Cherng Yang   +4 more
doaj   +1 more source

STRAD in Peutz-Jeghers syndrome and sporadic cancers [PDF]

, 2005
Background/Aims: LKB1 is a tumour suppressor gene that is associated with Peutz-Jeghers syndrome (PJS), a rare autosomal dominant cancer predisposition syndrome.
Leng, W.W. de, Keller, J.J., Luiten, S., Musler, A.R., Jansen, M., Baas, A.F., Rooij, F.W. de, Gille, J.J.P., Menko, F.H., Offerhaus, GJ, Weterman, M.A.   +10 more
core   +2 more sources

Apoptosis: A Key Process That Trypanosoma cruzi Modulates as a Strategy to Perpetuate Infection

Journal of Parasitology Research, Volume 2025, Issue 1, 2025.
Apoptosis is a crucial host defense mechanism because it can trigger the immune response and get rid of infected cells. These important goals, among others, are achieved through a fine‐tuned process that culminates in a quiet form of cell death. Apoptosis represents a hindrance for intracellular microorganisms that live inside cells. Nevertheless, they
Diego Maurizio Coria-Paredes, Arturo A. Wilkins-Rodríguez, Laila Gutiérrez-Kobeh, Sarita Kumar   +3 more
wiley   +1 more source

Proteomics of AML1/ETO Target Proteins: AML1–ETO Targets a C/EBP–NM23 Pathway [PDF]

, 2010
Introduction The rational design of targeted therapies for acute myeloid leukemia (AML) requires the discovery of novel protein pathways in the systems biology of a specific AML subtype.
Arun Kumar Trivedi, Gerhard Behre, Maximilian Christopeit, Savita Lochab, Sheo Mohan Singh, Wolfgang Hiddemann   +5 more
core   +1 more source

nm23-H1 expression and loss of heterozygosity in colon adenocarcinoma [PDF]

Journal of Clinical Pathology, 2004
Background:The discovery that genetic alterations in oncogenes and tumour suppressor genes accompany tumour formation in many human tumours has encouraged the search for genes that promote or suppress tumour spread and metastasis; nm23 is a promising candidate for a metastasis suppressing gene.Aims:To evaluate whether expression of nm23-H1 protein or ...
Pavelić, Krešimir, Čačev, Tamara, Cigrovski Berković, Maja, Kapitanović, Sanja, Seiwerth, Sven, Spaventi, Šime, Spaventi, Radan, Popović-Hadžija, Marijana, Radošević, Senka   +8 more
openaire   +4 more sources

COVID‐19 vaccine adverse events: Evaluating the pathophysiology with an emphasis on sulfur metabolism and endotheliopathy

European Journal of Clinical Investigation, Volume 54, Issue 10, October 2024.
The focus of this narrative review is to assess the pathophysiology of severe adverse events observed after vaccination with DNA and mRNA vaccines against COVID‐19. It is viewed from the perspective of an undersulfated and degraded glycocalyx, considering its impact on immunomodulation, inflammatory responses, coagulation and oxidative stress ...
Heidi N. du Preez, Johnson Lin, Glenn E. M. Maguire, Colleen Aldous, Hendrik G. Kruger   +4 more
wiley   +1 more source

RETRACTED: Association between cathepsins and skin cancers: A bidirectional two‐sample Mendelian randomization study

Skin Research and Technology, Volume 30, Issue 8, August 2024.
Abstract Background Several cathepsins have been identified as being involved in the development of cancer. Nevertheless, the connection between cathepsins and skin cancers remained highly elusive. Methods A bidirectional Mendelian randomization (MR) analysis was performed to investigate the causal association between cathepsins and skin malignancies ...
Xinyi Ma, Haocheng Zhuang, Mingze Xu, Fangzhen Hou, Chunyu Xue   +4 more
wiley   +1 more source