Results 71 to 80 of about 3,123 (185)

The mechanism of metastasis suppressor gene nm23-H1 involving in the Ras signaling of lung cancer

Chinese Journal of Lung Cancer, 2008
Background and objective It has been confirmed that nm23-H1 gene is one of the tumor metastasis suppressor genes. Up to now, the exact mechanism of nm23-H1 gebe is uncertain.
Xueqin YANG, Yibing YAO, Wen ZHU, Li MA, Daxing ZHU, Wen XIAO, Changlin LI, Jiabao MA, Zhixuan ZHANG, Liwei GAO, Yanping WANG, Qinghua ZHOU   +11 more
doaj  

Inhibition of invasion and metastasis of human liver cancer HCCLM3 cells by portulacerebroside A [PDF]

CONTEXT: Portulacerebroside A (PCA) is a novel cerebroside compound isolated from Portulaca oleracea L. (Portulacaceae), an edible and medicinal plant distributed in the temperate and tropical zones worldwide.
Bago R, Cervoni L, Chen YG, Faried A, Gialeli C, Guo-Yin Zheng, Hai-Liang Xin, Hakem A, Hofer MD, Hofer MD, Hong Zhang, Iguchi K, Jian-Yu Chen, Jiang L, Johnson E, Jung S, Kar A, Khalid Rahman, Kumar A, Kumar R, Li YP, Liu M, Mardilovich K, McDermott WG, Novak M, Paul A, Qian Ji, Rathinam R, Rubaci AH, Struckhoff AP, Thakur RK, Toh Y, Ueno K, Valastyan S, Wei Xia, Xin HL, Xiong-Yu Meng, Yan J, Zhang H, Zhang H, Zheng GY, Zins K   +41 more
core   +1 more source

Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1-TGF-β-OTX2-SNAIL via PTEN inhibition. [PDF]

, 2018
Genetic modifications during development of paediatric groups 3 and 4 medulloblastoma are responsible for their highly metastatic properties and poor patient survival rates.
Asadzadeh, F, Boffa, I, Brunetti, A, Carotenuto, M, Chesler, L, Cinalli, G, D'Argenio, V, Daniels, C, Danielson, L, de Antonellis, P, Del Monaco, V, Delattre, O, Diana, D, Donofrio, V, Errico, Me, Fattorusso, R, Ferrucci, V, Galeone, A, Gargiulo, S, Garzia, L, Giangaspero, F, Gramanzini, M, Liguori, L, Mastronuzzi, A, Montanaro, D, Navas, L, Pedone, E, Pennino, FRANCESCO PAOLO, Picard, D, Pisano, I, Quaglietta, L, Remke, M, Salvatore, F, Scognamiglio, I, Swartling, Fj, Taylor, Md, Tirone, F, Verrico, A, Virgilio, A, Weiss, Wa, Zollo, M.   +40 more
core   +1 more source

Establishment of the Cell Line that Human Lung Adenocarcinoma can Stably Express Luciferase Which is Absent of nm23-H1 Expression and Detecting Its Luminescence 
in vitro and in vivo

Chinese Journal of Lung Cancer, 2012
Background and objective On the condition that laboratory animals survive, we can detect the distribution of tumor cells by in vivo imaging that were labeled with firefly- luciferase (luc) gene.
Hongming WANG, Daxing ZHU, Zhihao WU, Qinghua ZHOU   +3 more
doaj   +1 more source

Development of an aptamer-based biosensing system for measuring luteinizing hormone pulsatility for infertility treatment [PDF]

, 2014
Poster Presentation - Theme 1: Cell biologyNormal fertility in human involves a highly orchestrated signal communication between the hypothalamic-pituitary-gonadal. The pulsatile release of Luteinizing Hormone (LH) from pituitary gland is the key element
Liang, S, Tanner, JA
core  

Introduction of human SOS physiological functions-Suggestions for resolving problems due to radiation exposure at low doses [PDF]

, 2016
ストレス社会対応の新しい教室を15年間主宰すべく,次の基本理念の基,研究と教育およびアウトリーチ活動を行いました。即ち,「科学における創造とは,未知のものを既知化し,非常識のものを常識化する」という作業です。具体的には,私共の創造作業とは,突然変異という従来の概念を「変異には必然性有り」とする考えへと変更させるものでした。この変異の発生を調節するメカニズムの解明は,生命研究の根源的課題であります。SOS応答という基本概念での研究ストラテジーでした。但し,多くの工夫が必要でした。まずは,約20年間をかけて,
Deepshikha RoyChowdhury (2818678), Katherine C. Patel (2818681), Katrina Pearson (2818690), Matthew K. Eblen (2818684), Robin M. Wagner (2818687)   +4 more
core   +3 more sources

Evidence for interaction between human PRUNE and nm23-H1 NDPKinase [PDF]

Oncogene, 1999
We have isolated a human and murine homologue of the Drosophila prune gene through dbEST searches. The gene is ubiquitously expressed in human adult tissues, while in mouse developing embryos a high level of expression is confined to the nervous system particularly in the dorsal root ganglia, cranial nerves, and neural retina.
REYMOND A, VOLORIO S, MERLA G, ALMAGHTHEH M, ZUFFARDI O, BULFONE A, BALLABIO, ANDREA, ZOLLO, MASSIMO   +7 more
openaire   +3 more sources

General and Specific Promotion of Flagellar Assembly by a Flagellar Nucleoside Diphosphate Kinase [PDF]

, 2017
Nucleoside diphosphate kinases (NDKs) play a central role in diverse cellular processes using the canonical NDK activity or alternative mechanisms that remain poorly defined.
Ciruelas, Kristine S., Diener, Dennis R., Gopal, Radhika, Ishikawa, Takashi, King, Stephen M., Liu, Yi, Maizy, Yousif, Poghosyan, Emiliya, Yang, Pinfen, Zhu, Xiaoyan   +9 more
core   +1 more source

Lycopene treatment of prostate cancer cell lines inhibits adhesion and migration properties of the cells [PDF]

, 2014
licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
Chopra, Mridula, Cooper, Alan, Elgass, Simone   +2 more
core   +1 more source

Multifaceted role of TREX2 in the skin defense against UV-induced skin carcinogenesis [PDF]

, 2017
TREX2 is a 3'-DNA exonuclease specifically expressed in keratinocytes. Here, we investigated the relevance and mechanisms of TREX2 in ultraviolet (UV)-induced skin carcinogenesis. TREX2 expression was up-regulated by chronic UV exposure whereas it was de-
Benito, Carmen, Cañas, Xavier, Eckhart, Leopold, Fischer, Heinz, Forcales Fernàndez, Sonia-Vanina, Garcia-Pedrero, Juana M., Gómez Fernández, Diana Lucía, Manils Pacheco, Joan, Marruecos, Laura, Marzo, Elena, Perrino, Fred W., Rodrigo, Juan P., Salgado, Rocío, Salla i Martret, Mercè, Serafin, Anna M., Serrano, Inma, Soler Prat, Concepció, Toll Abelló, Agustí   +17 more
core   +4 more sources