Results 271 to 280 of about 197,779 (358)

Persistence of quantal synaptic vesicle recycling in virtual absence of dynamins

The Journal of Physiology, EarlyView.
Abstract figure legend Figure depicts the key finding from this study. While loss of all dynamins severely debilitates synaptic vesicle retrieval following repetitive activity, retrieval and recycling of individual synaptic vesicles following spontaneous fusion or sparse stimulation are minimally affected.
Olusoji A. T. Afuwape, Natali L. Chanaday, Merve Kasap, Lisa M. Monteggia, Ege T. Kavalali   +4 more
wiley   +1 more source

Mutant prion protein enhances NMDA receptor activity, activates PKC, and triggers rapid excitotoxicity in mice. [PDF]

J Clin Invest
Lin J, Callender JA, Mayfield JE, McClatchy DB, Ojeda-Juárez D, Pourhamzeh M, Soldau K, Kurt TD, Danque GA, Khuu H, Ronson JE, Pizzo DP, Du Y, Gruber MA, Sevillano AM, Wang J, Orrú CD, Chen J, Funk G, Aguilar-Calvo P, Aulston BD, Roy S, Rho JM, Bui JD, Newton AC, Lipton SA, Caughey B, Patrick GN, Doré K, Yates JR, Sigurdson CJ.   +30 more
europepmc   +1 more source

Potentiation of neuronal NMDA response induced by dehydroepiandrosterone and its suppression by progesterone: effects mediated via sigma receptors

, 1996
Richard Bergeron, Claude de Montigny, Guy Debonnel   +2 more
openalex   +1 more source

GluN2C/D‐containing NMDA receptors enhance temporal summation and increase sound‐evoked and spontaneous firing in the inferior colliculus

The Journal of Physiology, EarlyView.
Abstract figure legend Here, we find that GluN2D‐containing NMDA receptors (NMDARs) are expressed by most vasoactive intestinal peptide neurons in the inferior colliculus (IC). These receptors are less susceptible to Mg2+ blockade compared to GluN2A/B‐containing NMDARs, allowing ions to flow at resting membrane potential.
Audrey C. Drotos, Rachel L. Zarb, Victoria Booth, Michael T. Roberts   +3 more
wiley   +1 more source

Time moving 100-fold slower: time distortion as a diagnostic clue in anti-NMDA receptor encephalitis. [PDF]

BMC Neurol
Hirata R, Wada H, Yamamoto K, Sogi Y, Muzuta H, Isaka Y, Funayama M.   +6 more
europepmc   +1 more source

Transcutaneous spinal cord stimulation at alternating intensities preferentially prevents the development of spasticity after contusion SCI in rat

The Journal of Physiology, EarlyView.
Abstract figure legend Previous work in humans and rodents has identified transcutaneous spinal cord stimulation as a promising strategy to reduce spasticity and hyperreflexia after spinal cord injury. The objective of this study was to deliver stimulation protocols with the intensity set (1) above motor threshold, (2) below motor threshold or (3 ...
Dillon C. Malloy, Jadwiga N. Bilchak, Marie‐Pascale Côté   +2 more
wiley   +1 more source

A Complex Case of Triumphantly Treated ​​​​​​Anti-N-Methyl-D-Aspartate (NMDA) Receptor Encephalitis. [PDF]

Cureus
Abu-Shanab A, Macasaet R, Mohd AB, Aquino D, Vangala A, Payal F, Du D.   +6 more
europepmc   +1 more source

Adaptations to hypoxia in the vertebrate retina

The Journal of Physiology, EarlyView.
Abstract figure legend Most animals, including mammals, are susceptible to the damaging effects of hypoxia or ischaemia, where the result is neuronal cell death in the brain. By contrast, some neurons of the mammalian retina are less sensitive to hypoxia. In both brain and retina, neurons may survive if first preconditioned with ischaemia.
Michael G. Jonz
wiley   +1 more source

Neonatal Procedural Pain Disrupts Phosphorylation of KCC2 in the Spinal Cord

Developmental Neurobiology, Volume 85, Issue 4, October 2025.
ABSTRACT Neonatal procedural pain experienced in the neonatal intensive care unit can lead to long‐lasting remodeling of the central nervous system and, in particular, of the spinal nociceptive network. Preclinical studies indicate a disrupted inhibitory versus excitatory balance in the spinal cord due to reduced γ‐aminobutyric acid (GABA) ergic ...
Mathilde Baudat, Elbert A. J Joosten, Sinno H. P. Simons, Daniël L. A. van den Hove, Renzo J. M. Riemens   +4 more
wiley   +1 more source

Modulation of NMDA receptor signaling and zinc chelation prevent seizure-like events in a zebrafish model of SLC13A5 epilepsy. [PDF]

PLoS Biol
Dogra D, Phan VA, Zhang S, Gavrilovici C, DiMarzo N, Narang A, Ibhazehiebo K, Kurrasch DM.   +7 more
europepmc   +1 more source