Results 271 to 280 of about 186,082 (377)

Bi-directional allosteric pathway in NMDA receptor activation and modulation. [PDF]

open access: yesNat Commun
Bender PA   +5 more
europepmc   +1 more source

On the mechanisms of brain blood flow regulation during hypoxia

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Schematic illustration of key hypothesized mechanisms mediating the cerebrovascular response to hypoxia, suggested by the results of studies included in this analysis. Abstract The brain requires an uninterrupted supply of oxygen and nutrients to support the high metabolic needs of billions of nerve cells processing information ...
Alexander Mascarenhas   +8 more
wiley   +1 more source

Translating physiology of the arterial chemoreflex into novel therapeutic interventions targeting carotid bodies in cardiometabolic disorders

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend The carotid body develops aberrant high activity in chronic heart failure, resistant hypertension, obstructive sleep apnoea (OSA) and diabetes. Hyperactivity of the carotid body leads to both high tonicity and increased sensitivity of the arterial chemoreflex with resultant sympathoexcitation.
Tymoteusz Żera   +7 more
wiley   +1 more source

Non‐ionotropic NMDAR signalling activates Panx1 to induce P2X4R‐dependent long‐term depression in the hippocampus

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Stimulation of the Shaffer collateral pathway at 3 Hz activates non‐ionotropic NMDA receptors. This subsequently leads to Src kinase mediated phosphorylation of pannexin‐1 (Panx1), which releases ATP from the postsynaptic cell. ATP acts as a ligand for P2X4 receptors to induce long‐term depression (LTD). Abstract In recent years,
Allison C. Nielsen   +4 more
wiley   +1 more source

Dual role for pannexin 1 at synapses: regulating functional and morphological plasticity

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Pannexin 1 (PANX1) regulation of dendritic spines. The postnatal decrease in PANX1 expression could release key spine cytoskeleton‐regulating proteins enabling spine stabilization. Does the physiological decrease in neuronal PANX1 levels across brain development underlie dendritic spine maturation?
Adriana Casillas Martinez   +3 more
wiley   +1 more source

The synaptic vesicle cluster as a controller of pre‐ and postsynaptic structure and function

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend The synaptic vesicle cluster acts as a master regulator of synaptic structure and function, through various involvements in processes that range from synaptic initiation to plasticity and synaptic loss. Abstract The synaptic vesicle cluster (SVC) is an essential component of chemical synapses, which provides neurotransmitter ...
Sofiia Reshetniak   +35 more
wiley   +1 more source

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