Results 291 to 300 of about 186,082 (377)

Dysfunction of the NMDA Receptor in the Pathophysiology of Schizophrenia and/or the Pathomechanisms of Treatment-Resistant Schizophrenia. [PDF]

Biomolecules
Okubo R, Okada M, Motomura E.
europepmc   +1 more source

Modeling the effect of glutamate diffusion and uptake on NMDA and non-NMDA receptor saturation

, 1995
William R. Holmes
openalex   +1 more source

The human intelligence evolved from proximal cis‐regulatory saltations

Quantitative Biology, Volume 13, Issue 2, June 2025.
Abstract The divergence rate between the alignable genomes of humans and chimpanzees is as little as 1.23%. Their phenotypical difference was hypothesized to be accounted for by gene regulation. We construct the cis‐regulatory element frequency (CREF) matrix to represent the proximal regulatory sequences for each species.
Xiaojie Li, Jianhui Shi, Lei M. Li
wiley   +1 more source

Role of Glutamate Excitotoxicity in Glioblastoma Growth and Its Implications in Treatment

Cell Biology International, Volume 49, Issue 5, Page 421-434, May 2025.
ABSTRACT Glioblastoma is a highly malignant and invasive type of primary brain tumor that originates from astrocytes. Glutamate, a neurotransmitter in the brain plays a crucial role in excitotoxic cell death. Excessive glutamate triggers a pathological process known as glutamate excitotoxicity, leading to neuronal damage.
Colin Moriarty, Natasha Gupta, Debanjan Bhattacharya   +2 more
wiley   +1 more source

Elevated peripheral glutamate and upregulated expression of NMDA receptor NR1 subunit in insomnia disorder. [PDF]

Front Psychiatry
Lin J, Hou X, Liu Y, Cai Y, Pan J, Liao J.   +5 more
europepmc   +1 more source

Ryanodine produces a low frequency stimulation‐induced NMDA receptor‐independent long‐term potentiation in the rat dentate gyrus in vitro.

, 1996
Y Wang, Jiaxiang Wu, Michael J. Rowan, Roger Anwyl   +3 more
openalex   +2 more sources

Role of Serum Brain‐Derived Neurotrophic Factor as a Biomarker of Chronic Pain in Older Adults

European Journal of Pain, Volume 29, Issue 5, May 2025.
ABSTRACT Background Serum brain‐derived neurotrophic factor (BDNF) has emerged as a promising biomarker for chronic pain (CP) research and treatment. Yet, most human studies have been limited by small sample sizes, inadequate control of confounders and a lack of focus on sex and mental health differences.
R. Ortolá, M. Sotos‐Prieto, A. Carballo, S. Cabello‐Plan, Aida Koni, V. Mustieles, L. M. García‐Segura, A. R. Artalejo, F. Rodríguez‐Artalejo, E. García‐Esquinas   +9 more
wiley   +1 more source

Optochemical profiling of NMDA receptor molecular diversity at synaptic and extrasynaptic sites

Sicard A, Tian M, Mostefai Z, Shi S, Cardoso C, Zamith J, McCort-Tranchepain I, Charrier C, Paoletti P, Mony L.   +9 more
europepmc   +1 more source

Successful sequential therapy with rituximab and telitacicept in refractory Anti-NMDA receptor encephalitis and MOG-associated demyelination: a case report and literature review. [PDF]

Front Immunol
Zhang J, Hu M, Wang C, Guo S.
europepmc   +1 more source

Ibudilast Protects Retinal Bipolar Cells From Excitotoxic Retinal Damage and Activates the mTOR Pathway

Glia, Volume 73, Issue 5, Page 905-927, May 2025.
Main Points Ibudilast, a MIF and PDE inhibitor, preserves the form and function of the retina, especially bipolar cells, during excitotoxic damage. Ibudilast upregulates multiple signaling pathways, including mTOR, in damaged Müller glia and bipolar cells.
Sumaya Hamadmad, Tyler Heisler‐Taylor, Sandeep Goswami, Evan Hawthorn, Sameer Chaurasia, Dena Martini, Diana Summitt, Ali Zatari, Rahaf Shalash, Misha Sohail, Elizabeth G. Urbanski, Kayla Bernstein, Julie Racine, Abhay Satoskar, Heithem M. El‐Hodiri, Andy J. Fischer, Colleen M. Cebulla   +16 more
wiley   +1 more source