Results 91 to 100 of about 8,840 (216)

Incidence of Hepatitis B Virus Reactivation in Patients Treated With Immunosuppressive and Chemotherapeutic Agents

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 5, Page 625-634, September 2026.
HBV reactivation incidence varied across immunosuppressive and chemotherapeutic agents. Clinically meaningful HBV reactivation was also observed in patients receiving corticosteroids and conventional immunosuppressive therapies. ABSTRACT Background Data on the incidence of hepatitis B virus reactivation (HBVr) remain limited. In Japan, patients who are
Kazuhiko Ikeuchi, Makoto Saito, Kazuya Okushin, Toshiyuki Kishida, Akira Kado, Kyoji Moriya, Kazuhiko Koike, Takeya Tsutsumi, Hiroshi Yotsuyanagi   +8 more
wiley   +1 more source

Identifizierung pathogener Signalwege der Neutrophile bei NMOSD und MOGAD [PDF]

Neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glyco-protein antibody-associated disease (MOGAD) are rare chronic demyelinating autoimmune disorders of the central nervous system (CNS).
Schroeder Castagno, Maria Eugenia
core   +1 more source

Integrated Engineering of CAR‐T Cells for Solid Tumours

Cell Proliferation, Volume 59, Issue 9, September 2026.
Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang, Tan Li, Ping He, Zhijie Zhao, Shenglong Li, Liming Wang   +5 more
wiley   +1 more source

TRIM21 autoantibodies are associated with blood-brain barrier dysfunction in a subgroup of neuromyelitis optica spectrum disorder

Acta Neuropathologica Communications
We previously reported that glucose-regulated protein 78 autoantibodies (GRP78 Ab) cause breakdown of the blood-brain barrier (BBB) in neuromyelitis optica spectrum disorder (NMOSD) patients. Objective of the present study is to identify novel antibodies
Fumitaka Shimizu, Chihiro Kadono, Masatoshi Yuri, Hirotada Fujita, Yoichi Mizukami, Kenji Watanabe, Nanami Yamanaka, Masayuki Nakamori   +7 more
doaj   +1 more source

Physiologically Based Pharmacokinetic Modeling to Predict Human Starting Dose and Pharmacokinetics for Rocbrutinib

Clinical and Translational Science, Volume 19, Issue 9, September 2026.
ABSTRACT Rocbrutinib is a fourth‐generation Bruton's tyrosine kinase (BTK) inhibitor that covalently binds wild‐type BTK and non‐covalently engages the C481S mutant. Its pharmacokinetic (PK) characteristics in healthy Chinese subjects remain unclear. This study aimed to support maximum recommended starting dose (MRSD) selection and predict exposure of ...
Lu Wang, Dandan Yang, Rong Shao, Jinliang Chen, Xiaodan Wang, Zheng Wang, Bo Jiang   +6 more
wiley   +1 more source

Clinical characteristics of patients with NMOSD.

, 2016
Clinical characteristics of patients with NMOSD.
Takayuki Baba (2372914), Setsu Sawai (508902), Satoshi Kuwabara (611904), Ryutaro Akiba (3390491), Hirotaka Yokouchi (3390488), Toshiyuki Oshitari (3390485), Masahiro Mori (528273), Shuichi Yamamoto (182616)   +7 more
core   +1 more source

Differences in clinical features between optic neuritis in neuromyelitis optica spectrum disorders and in multiple sclerosis

Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2018
Background Optic neuritis (ON) is one of the common manifestations both in neuromyelitis-optica spectrum disorders (NMOSD) and in multiple sclerosis (MS).
Jindapa Srikajon, Sasitorn Siritho, Chanon Ngamsombat, Naraporn Prayoonwiwat, Niphon Chirapapaisan,   +5 more
doaj   +1 more source

Differences in disease burden between neuromyelitis optica spectrum disorder and multiple sclerosis in South China

Multiple Sclerosis Journal - Experimental, Translational and Clinical
Background Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) differ substantially in pathophysiological mechanisms, clinical manifestations and therapeutic management.
Xin Huang, Huiyu Feng, Jingjing Li, Yuhua Fan, Jinsheng Zeng   +4 more
doaj   +1 more source

Neuromyelitis Optica Spectrum Disorder (NMOSD): Challenges and Updates

Pendahuluan: Neuromyelitis optica spectrum disorder (NMOSD) merupakan kondisi autoimun yang ditandai dengan inflamasi pada nervus optikus, saraf spinal, dan sistem saraf pusat.
Sidik, Mohamad, Priscilia, Florentina, Casey, Anthea, Iskandar, Ferdy   +3 more
core   +1 more source

Neuromyelitis Optica Spectrum Disorder in Latin America: State-of-the-Art and Current Challenges

Journal of Integrative Neuroscience
Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune disease of the central nervous system characterized by severe attacks of optic neuritis, myelitis, and/or area postrema.
Edgar Carnero Contentti, Bárbara Eizaguirre, Pablo A. López, Berenice Silva, Verónica A. Tkachuk, Santiago Tizio, Ricardo Alonso   +6 more
doaj   +1 more source