Results 71 to 80 of about 9,281 (210)

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Collaborative International Research in Clinical and Longitudinal Experience Study in NMOSD

, 2019
Objective: To develop a resource of systematically collected, longitudinal clinical data and biospecimens for assisting in the investigation into neuromyelitis optica spectrum disorder (NMOSD) epidemiology, pathogenesis, and treatment.
Broadley, Simon, Cook, Lawrence J, Levy, Michael, McKechnie, Stephen, Kuhn, Renee, Tomczak, Anna J, Enriquez, Rene, Han, May H, Jolley, Anna Marie, Yearley, Jeff, Alvey, Jessica S, Rose, John W, Pederson, Melissa, et al., Marron, Brie   +14 more
core   +1 more source

Increased Intracranial Pressure on a Patient with Neuromyelitis Optica Spectrum Disorder

Caspian Journal of Internal Medicine, 2021
Background: Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune astrocytopathic disease affecting central nervous system (CNS). CSF pressure in these patients is usually normal.
Seyed Mohammad Forouzannia, Pourya Yarahmadi, Mohammad Alirezaei, Nasim Rezaeimanesh, Abdorreza Naser Moghadasi   +4 more
doaj  

Short segment myelitis as the initial and only manifestation of aquaporin-4 immunoglobulin G-positive neuromyelitis optica spectrum disorders

Therapeutic Advances in Neurological Disorders, 2020
Background: Short segment myelitis (SSM, < 3 vertebral segments) is an under-recognized initial manifestation of neuromyelitis optica spectrum disorders (NMOSD).
Wei Fang*, Yang Zheng*, Fan Yang, Meng-Ting Cai, Chun-Hong Shen, Zhi-Rong Liu, Yin-Xi Zhang, Mei-Ping Ding   +7 more
doaj   +1 more source

Serum antinuclear antibodies associate with worse prognosis in AQP4‐positive neuromyelitis optica spectrum disorder

Brain and Behavior, 2021
Background Studies have demonstrated that antinuclear antibodies (ANAs) may be correlated with neuromyelitis optica spectrum disorder (NMOSD). However, the conflicting results of studies about the value of ANAs in AQP4 antibody‐positive NMOSD patients ...
Rong Fan, Yuefeng Zhang, Yunqi Xu, Jiayi Tong, Zhigang Chen, Meifeng Gu, Wenkui Fan, Yong Chen, Fuhua Peng, Ying Jiang   +9 more
doaj   +1 more source

A study of referral bias in NMOSD and MOGAD cohorts. [PDF]

BACKGROUND: Neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are rare disorders often seen in highly specialized services or tertiary centres.
Sharawakanda, Y, Fisniku, L, Francis, A, Miron, M, Cooper, S, Hobart, J, Messina, S, Halfpenny, C, Williams, V, Hacohen, Y, Ramdas, S, Rashid, W, Palace, J, Geraldes, R, Hemingway, C, Leal Rato, M, Martin, R, O'Sullivan, E, Leite, MI, Chen, B, Dobson, R, Hobart, Jeremy, Leal Rato, Miguel, Fisniku, Leonora, Miron, Madalina, Hemingway, Cheryl, Martin, Roswell, Cooper, Sarah, Francis, Anna, Halfpenny, Christopher, Palace, Jacqueline, Messina, Silvia, Sharawakanda, Yvonne, Rashid, Waqar, Dobson, Ruth, Hacohen, Yael, Ramdas, Sithara, Geraldes, Ruth, Leite, Maria Isabel, O\u27Sullivan, Eoin, Chen, Bo, Williams, Victoria   +41 more
core   +1 more source

GRADE summary of findings between NMOSD patients and healthy controls.

, 2023
GRADE summary of findings between NMOSD patients and healthy controls.
Fernando Andres Terry-Escalante (14593644), Carlos Alva-Díaz (11591728), Miguel Cabanillas-Lazo (14593635), Claudia Cruzalegui-Bazán (14593638), Carlos Quispe-Vicuña (14593641), Nicanor Mori (454352), Milagros Pascual-Guevara (13822251)   +6 more
core   +1 more source

Brain lesion distribution criteria distinguish MS from AQP4-antibody NMOSD and MOG-antibody disease [PDF]

, 2016
IMPORTANCE: Neuromyelitis optica spectrum disorders (NMOSD) can present with very similar clinical features to multiple sclerosis (MS), but the international diagnostic imaging criteria for MS are not necessarily helpful in distinguishing these two ...
Kremer, S., Matthews, Lucy, Juryńczyk, Maciej, Craner, Matthew, Matthews, L., Woodhall, Mark, Leite, M.I., Tackley, George, Kong, Yazhuo, Palace, Jacqueline, Waters, P., De Seze, J., Vincent, Angela, Tackley, G., Geraldes, R., Jacob, Anu, Kuker, Wilhelm, Craner, M., Jurynczyk, M., Jacob, A., Waters, Patrick, Weir, Andrew, Vincent, A., Kuker, W., Woodhall, M., Kong, Y., Deluca, Gabriele C, Geraldes, Ruth, Leite, Maria Isabel, Palace, J., Kremer, Stephane, Deluca, G.C., Weir, A., de Seze, Jerome   +33 more
core   +1 more source

Top‐Down CSF Peptidomics Reveals Disease‐Associated Peptide Signatures and Oxidative Modifications in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder

PROTEOMICS, EarlyView.
ABSTRACT Multiple sclerosis and neuromyelitis optica spectrum disorder (NMOSD) are inflammatory demyelinating diseases of the CNS whose diagnosis is mainly based on clinical evidence, magnetic resonance imaging, and the analysis of cerebrospinal fluid (CSF). Current approaches provide only partial insight into disease‐related biological processes, thus
Cristina Contini, Lorena Lorefice, Greca Lai, Alessandra Schirru, Giorgia Zodio, Tiziana Cabras, Alessandra Olianas, Giacomo Diaz, Eleonora Cocco, Barbara Manconi   +9 more
wiley   +1 more source

Predictors of relapse risk and treatment response in AQP4-IgG positive and seronegative NMOSD : a multicentre study [PDF]

Background Neuromyelitis optica spectrum disorder (NMOSD) can be categorised into aquaporin-4 antibody (AQP4-IgG) NMOSD or seronegative NMOSD. While our knowledge of AQP4-IgG NMOSD has evolved significantly in the past decade, seronegative NMOSD remains ...
Surcinelli, A., Khoury, Samia Joseph, Patti, F., Foschi, Matteo, Huda, S., McCombe, Pamela A, Etemadifar, Masoud, Siriratnam Pakeeran, Scott, J. L., Altintas, A., Yamout, Bassem, van der Walt, A., Sharmin, Sifat, Csepany, T., Sanfilippo Paul, Butzkueven, Helmut, Nytrova, Petra, Laureys, Guy, Turkoglu, Recai, van der Walt, Foong, Y. C., Willekens, B., Ozakbas, S., group, Msbase study, Foong, Yi Chao, Butzkueven, H., Soysal, A., Surcinelli, Andrea, Alroughani, Raed, Lechner Scott, Jeanette, Nytrova, P., Simo, M., Willekens, Barbara, Jokubaitis, V., Van Hijfte, Liesbeth, Anneke, MSBASE study group, [missing], Zhu, Chao, Sánchez-Menoyo, J. L., Laureys, G., Turkoglu, R., Al-Asmi, A., Altintas, Ayse, Etemadifar, M., Al-Asmi, Abdullah, Sánchez-Menoyo, José Luis, Yamout, B., Yeh, Wei Zhen, Ozakbas, Serkan, Zhu, C., Lechner Scott, J., Khoury, S. J., Siriratnam, Pakeeran, Siriratnam, P., Patti, Francesco, Sharmin, S., Soysal, Aysun, Simo, Magdolna, Yeh, W. Z., Alroughani, R., Sanfilippo, P., Sanfilippo, Paul, Foschi, M., McCombe, P. A., Csepany, Tunde, Ozakbas Serkan, Jokubaitis, Vilija, Huda, Saif, Monif, Mastura, Kalincik, Tomas, Kalincik, T., Monif, M., van der Walt, Anneke, S\ue1nchez-Menoyo, Jos\ue9 Luis, Hardy, Todd   +74 more
core   +2 more sources