Results 61 to 70 of about 8,840 (216)

Delayed diagnosis of the neuromyelitis optica spectrum disorder

Неврология, нейропсихиатрия, психосоматика, 2023
Neuromyelitis optica spectrum disorders (NMOSD) are a group of autoimmune inflammatory demyelinating diseases of the central nervous system. In 2015, International Expert Panel established diagnostic criteria for NMOSD.
S. A. Dzhukkaeva, E. V. Ermilova, Sh. R. Nabiev, O. N. Voskresenskaya   +3 more
doaj   +1 more source

Correlation of GABA+ levels in the medial prefrontal cortex and circulating follicular helper T cells in neuromyelitis optica spectrum disorder patients with cognitive impairment

Brain and Behavior
Background Neuromyelitis optica spectrum disorder (NMOSD) associated with cognitive impairment (CI) is acknowledged. However, the underlying pathogenesis and involvement of the immune system remain unclear.
Yinghui Duan, Qianyun Rui, Yang Yang, Jingluan Tian, Shugang Cao, Feng Zhu, Xiaoyu Duan, Hanqing Gao, Xiaopei Ji, Xinyi Xiao, Yonggang Li, Qun Xue   +11 more
doaj   +1 more source

Regulatory T cells protect against brain damage by alleviating inflammatory response in neuromyelitis optica spectrum disorder

Journal of Neuroinflammation, 2021
Background and purpose Neuromyelitis optica spectrum disorder (NMOSD) is mainly an anti-aquaporin 4 (anti-AQP4) autoantibodies-mediated idiopathic inflammatory demyelinating disease of the central nervous system. Systemic and local inflammatory responses
Xue Ma, Chuan Qin, Man Chen, Hai-Han Yu, Yun-Hui Chu, Ting-Jun Chen, Dale B. Bosco, Long-Jun Wu, Bi-Tao Bu, Wei Wang, Dai-Shi Tian   +10 more
doaj   +1 more source

NMOSD—Diagnostic Dilemmas Leading towards Final Diagnosis

, 2022
(1) Background: The emergence of white matter lesions in the central nervous system (CNS) can lead to diagnostic dilemmas. They are a common radiological symptom and their patterns may overlap CNS or systemic diseases and provoke underdiagnosis or ...
Woś, Michał, Konrad Rejdak, Szewczyk, Anna K., Michał Woś, Rejdak, Konrad, Krystyna Mitosek-Szewczyk, Anna K. Szewczyk, Ewa Papuć, Mitosek-Szewczyk, Krystyna, Papuć, Ewa   +9 more
core   +1 more source

Characteristics of recurrence in area postrema-onset NMO spectrum disorder - a retrospective cohort study

BMC Neurology
Background Neuromyelitis Optica Spectrum Disorder (NMOSD) is an inflammatory autoimmune disease with high risk of recurrence and disability, the treatment goal is a recurrence free state.
Xianxing Zhang, Jin Wu, Jingyu Lin, Shifang Lin, Aiyu Lin   +4 more
doaj   +1 more source

NMOSD Prodrome

In this study we investigate whether patients with neuromyelitis optica spectrum disorder (NMOSD) experience symptoms in the years before the first NMOSD attack.
Sydney Lee (17971667)
core   +1 more source

Unveiling the retinal secrets of neuromyelitis optica spectrum disorder

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
Background Vascular alterations are now recognized as important contributors to the pathophysiology of neuromyelitis optica spectrum disorder (NMOSD).
Amal S. Ashour, Omar El Serafy, Nervana Mohamed El Fayoumy, Amr Hassan, Nehal Samy El Gendy, Eman Salah Heikal, Hadeel Ahmed, Salsabil Abo Al-Azayem   +7 more
doaj   +1 more source

Abnormal brain spontaneous neural activity in neuromyelitis optica spectrum disorder with neuropathic pain

Frontiers in Neurology
BackgroundNeuropathic pain is one of the most common symptoms in neuromyelitis optica spectrum disorder (NMOSD). Notwithstanding, its underlying mechanism remains obscure.MethodsThe amplitude of low-frequency fluctuations (ALFF) metric was employed to ...
Gendi Wang, Gendi Wang, Xiang Chen, Xiaoyuan Wang, Yinghui Duan, Hanqing Gao, Xiaopei Ji, Yunfei Zhu, Xuanyi Xiang, Hairong Ma, Yonggang Li, Yonggang Li, Yonggang Li, Qun Xue, Qun Xue, Qun Xue   +15 more
doaj   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Autoantibody to MOG suggests two distinct clinical subtypes of NMOSD [PDF]

, 2016
We characterized a unique group of patients with neuromyelitis optica spectrum disorder (NMOSD) who carried autoantibodies of aquaporin-4 (AQP4) and myelin-oligodendrocyte glycoprotein (MOG).
Fu, Ying, Fu-Dong Shi, Shi, Fu-Dong, Yang, Li, Yaou Liu, Jeffrey L. Bennett, Borazanci, Aimee, Kaibin Shi, Qiang Liu, Yaping Yan, Li, Yujing, Lei Su, Liu, Yaou, Yong He, Timothy L. Vollmer, Minshu Li, Li, Minshu, Liu, Qiang, He, Yong, Shi, Kaibin, Ying Fu, Li Yang, Yan, Yaping, Aimee Borazanci, Yujing Li, Bennett, Jeffrey L., Su, Lei, Vollmer, Timothy L.   +27 more
core   +1 more source