Results 41 to 50 of about 8,840 (216)

Research Progress on the Animal Models of Neuromyelitis Optica Spectrum Disorders-related Neuropathic Pain

Xiehe Yixue Zazhi, 2023
Neuromyelitis optica spectrum disorders(NMOSD), an inflammatory demyelinating disease of central nervous system, is characterized by optic neuritis, longitudinally extensive transverse myelitis, and neuropathic pain.
SONG Shujia, PEI Lijian, XU Yan, ZHANG Xue, HUANG Yuguang   +4 more
doaj   +1 more source

Neuroophthalmological evaluation in primary inflammatory demyelinating diseases with special reference to optic neuritis: A prospective study

Journal of Family Medicine and Primary Care
Introduction: The involvement of ocular system especially optic neuritis (ON) is an important clinical aspect of inflammatory demyelinating disease (IDD) of the central nervous system.
Ankit Khetan, Rajesh Verma, Rajarshi Chakraborty, Ravindra Kumar Garg, Hardeep Singh Malhotra, Praveen Kumar Sharma, Neeraj Kumar, Ravi Uniyal, Shweta Pandey, Imran Rizvi   +9 more
doaj   +1 more source

Is there a prodrome to NMOSD? An investigation of neurologic symptoms preceding the first NMOSD attack

Multiple Sclerosis Journal
Background: It is unknown whether people with aquaporin-4 antibody positive (AQP4-IgG+) neuromyelitis optica spectrum disorder (NMOSD) experience a prodrome, although a few cases report AQP4 + serology up to 16 years before the first attack. Objectives:
Sydney Lee, Ruth Ann Marrie, Giulia Fadda, Mark S Freedman, Liesly Lee, Alexandra Muccilli, Manav V Vyas, Andrea Konig, Dalia L. Rotstein   +8 more
openaire   +2 more sources

Opposing Influences of Optic Neuritis and Transverse Myelitis on the Future Location of Relapses in MOG Antibody–Associated Disease

Brain and Behavior
Background Studies in MS and NMOSD have shown that relapses can frequently occur in the same location as the first attack. Factors associated with this outcome in MOGAD are unclear.
Daniel Lordelo San Martin, Marcos Baruch Portela Filho, Chiara Rocchi, Shahd Hamid, Saif Huda   +4 more
doaj   +1 more source

Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Cognitive impairment is common in multiple sclerosis (MS), but manifestations following the first demyelinating event are relatively unexplored. We investigated cross‐sectional associations between magnetic resonance imaging (MRI)–derived brain volumes and the presence of cognitive impairment outcomes five years after the first ...
Piriyankan Ananthavarathan, Marco Pitteri, Michael Foster, Sara Collorone, Sara Salama, Elisa Colato, Ferran Prados, Baris Kanber, Marios Yiannakas, Claudia A. M. Gandini Wheeler‐Kingshott, Indran Davagnanam, Frederik Barkhof, Declan Chard, Olga Ciccarelli, Ahmed Toosy   +14 more
wiley   +1 more source

Collaborative International Research in Clinical and Longitudinal Experience Study in NMOSD

, 2019
Objective: To develop a resource of systematically collected, longitudinal clinical data and biospecimens for assisting in the investigation into neuromyelitis optica spectrum disorder (NMOSD) epidemiology, pathogenesis, and treatment.
Broadley, Simon, Cook, Lawrence J, Levy, Michael, McKechnie, Stephen, Kuhn, Renee, Tomczak, Anna J, Enriquez, Rene, Han, May H, Jolley, Anna Marie, Yearley, Jeff, Alvey, Jessica S, Rose, John W, Pederson, Melissa, et al., Marron, Brie   +14 more
core   +1 more source

Understanding Further the Phenotypic Spectrum of Central Nervous System Inflammatory Demyelinating Disorders Using Unsupervised Clustering

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Central nervous system (CNS) inflammatory demyelinating syndromes, including multiple sclerosis (MS), aquaporin‐4 antibody–positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD), occasionally overlap.
Bade Gulec, Elif Everest, Melih Tutuncu, Ugur Bilge, Sabahattin Saip, Ugur Uygunoglu, Aksel Siva   +6 more
wiley   +1 more source

Cerebrospinal fluid mitochondrial DNA in neuromyelitis optica spectrum disorder

Journal of Neuroinflammation, 2018
Background Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory disease of the central nervous system. Although complement-dependent astrocyte damage mediated by anti-aquaporin 4 autoantibody (AQP4-Ab) is well acknowledged to be the core of ...
Kazuya Yamashita, Makoto Kinoshita, Katsuichi Miyamoto, Akiko Namba, Mikito Shimizu, Toru Koda, Tomoyuki Sugimoto, Yuki Mori, Yoshichika Yoshioka, Yuji Nakatsuji, Atsushi Kumanogoh, Susumu Kusunoki, Hideki Mochizuki, Tatsusada Okuno   +13 more
doaj   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Clinical and immunological differences between primary and autoimmune-associated neuromyelitis optica spectrum disorders: a retrospective study

Lupus Science and Medicine
Introduction Neuromyelitis optica spectrum disorder (NMOSD) is a rare immune-mediated disease affecting the spinal cord and optic nerves. While NMOSD has been widely studied, limited data exist on the subset associated with autoimmune diseases (AD-NMOSD),
Hsien-Tzung Liao, Chang-Youh Tsai, Wei-Sheng Chen, Ying-Ying Yang, Hung-Cheng Tsai, Yi-Syuan Sun, Wan-Hao Tsai, De-Feng Huang   +7 more
doaj   +1 more source