Results 51 to 60 of about 9,281 (210)

Is there a prodrome to NMOSD? An investigation of neurologic symptoms preceding the first NMOSD attack

Multiple Sclerosis Journal
Background: It is unknown whether people with aquaporin-4 antibody positive (AQP4-IgG+) neuromyelitis optica spectrum disorder (NMOSD) experience a prodrome, although a few cases report AQP4 + serology up to 16 years before the first attack. Objectives:
Sydney Lee, Ruth Ann Marrie, Giulia Fadda, Mark S Freedman, Liesly Lee, Alexandra Muccilli, Manav V Vyas, Andrea Konig, Dalia L. Rotstein   +8 more
openaire   +2 more sources

MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Jonathan Rosen, Jesse M. Levine, Karla Salazar, Madhuri Chilakapati, Rod Foroozan, Victoria Hardwick, Jonathan M. Yarimi, Nikita Shukla, Timothy E. Lotze, Kristen S. Fisher, Alexander J. Sandweiss   +13 more
wiley   +1 more source

Clinical and immunological differences between primary and autoimmune-associated neuromyelitis optica spectrum disorders: a retrospective study

Lupus Science and Medicine
Introduction Neuromyelitis optica spectrum disorder (NMOSD) is a rare immune-mediated disease affecting the spinal cord and optic nerves. While NMOSD has been widely studied, limited data exist on the subset associated with autoimmune diseases (AD-NMOSD),
Hsien-Tzung Liao, Chang-Youh Tsai, Wei-Sheng Chen, Ying-Ying Yang, Hung-Cheng Tsai, Yi-Syuan Sun, Wan-Hao Tsai, De-Feng Huang   +7 more
doaj   +1 more source

Clinical and Modifiable Factors Associated With Disability and Relapse in MOGAD: A Multicentre Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Factors associated with relapse course and disability in myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) remain incompletely understood. Objectives To identify clinical and modifiable factors associated with relapse and disability in MOGAD. Methods In this ambispective multicentre cohort study using data from
Yingtao Wang, Shaoxin Tao, Qiujia Wang, Xiaoyu Xu, Hui Yao, Zheng Liu, Dawei Li, Zhandong Qiu, Jinming Han, Jiangwei Xia, Qi Wang, Jun Sun, Kai Shao, Jiao Li, Shishuang Ruan, Yi Zhong, Jun Guo, Shougang Guo, Yue Huang, Guoliang Chai, Tao Jin, Hongyu Zhou, Junwei Hao, Yinan Zhao   +23 more
wiley   +1 more source

Quantitative MRI Uncovers Subtle Cortical Damage in Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether myelin‐sensitive quantitative MRI reveals microstructural abnormalities in normal‐appearing cortex (NACtx) in myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), indicating that conventional MRI underestimates remission residual cortical injury.
Valentina Camera, Agnese Tamanti, Silvia Messina, Nicola Dall'Osto, Teresa Maltempo, Stefano Ziccardi, Matteo Foschi, Maria Grazia Piscaglia, Diana Ferraro, Francesco Crescenzo, Francesca Rossi, Albulena Bajrami, Sabrina Marangoni, Damiano Marastoni, Francesca Benedetta Pizzini, Maria Isabel Leite, Roberta Magliozzi, Patrick Waters, Massimiliano Calabrese, Jacqueline Palace, Ruth Geraldes   +20 more
wiley   +1 more source

Prevalence of NMOSD and MS in the Indigenous Populations of Australia and New Zealand

, 2020
Background: Neuromyelitisoptica spectrum disorders (NMOSD) and multiple sclerosis (MS) have differing population frequencies according to ethnic ancestry.
Fabis-Pedrini, M, Bukhari, W, Subramanian, S, Broadley, SA, Mason, F, Barnett, MH, Kermode, AG, Waters, P, Khalilidehkordi, E, Taylor, B, Medeiros-Furquim, Tiago; id_orcid, Alroughani, R, Mao-Draayer, Y, Navas, C, Vermersch, P, Nakamura, K, Broadley, S, Kim, HJ, Wray, S, Rovira, A, Bass, AD, Havrdova, EK, Hartung, H-P, Comi, G, Selmaj, KW, et al.   +25 more
core   +2 more sources

“Low‐Positive” MOG‐IgG Cases Among Adults With a First Event Suggestive of Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the prevalence and clinical characteristics of patients with “low‐positive” (LP) MOG‐IgG (titres 1:160–1:320) among adults with a first demyelinating event (FDE) suggestive of multiple sclerosis (MS). Methods From the Barcelona CIS inception cohort, we included adult patients with serum collected ≤ 6 months from the FDE.
Javier Villacieros‐Álvarez, Carmen Espejo, Georgina Arrambide, Mireia Castillo, Marta Rodriguez, Helena Ariño, Iker Elosua, Carmen Tur, Angela Vidal‐Jordana, Andreu Vilaseca, Joaquín Castilló, Ingrid Galán, Luciana Midaglia, Carlos Nos, Breogan Rodríguez‐Acevedo, Ana Zabalza, Luca Bollo, Agustín Pappolla, René Carvajal, Neus Mongay‐Ochoa, Jordi Rio, Jaume Sastre‐Garriga, Manuel Comabella, Gesualdina Busiello, Sofia Sceppacuercia, Àlex Rovira, Xavier Montalban, Mar Tintoré, Cristina Auger, Álvaro Cobo‐Calvo   +29 more
wiley   +1 more source

Predictive role of blood-based indicators in neuromyelitis optica spectrum disorders

Frontiers in Neuroscience, 2023
IntroductionThis study aimed to assess the predictive role of blood markers in neuromyelitis optica spectrum disorders (NMOSD).MethodsData from patients with NMOSD, multiple sclerosis (MS), and healthy individuals were retrospectively collected in a 1:1 ...
Xiqin Fang, Xiqin Fang, Sujuan Sun, Sujuan Sun, Tingting Yang, Tingting Yang, Xuewu Liu, Xuewu Liu   +7 more
doaj   +1 more source

Correlation of GABA+ levels in the medial prefrontal cortex and circulating follicular helper T cells in neuromyelitis optica spectrum disorder patients with cognitive impairment

Brain and Behavior
Background Neuromyelitis optica spectrum disorder (NMOSD) associated with cognitive impairment (CI) is acknowledged. However, the underlying pathogenesis and involvement of the immune system remain unclear.
Yinghui Duan, Qianyun Rui, Yang Yang, Jingluan Tian, Shugang Cao, Feng Zhu, Xiaoyu Duan, Hanqing Gao, Xiaopei Ji, Xinyi Xiao, Yonggang Li, Qun Xue   +11 more
doaj   +1 more source

Regulatory T cells protect against brain damage by alleviating inflammatory response in neuromyelitis optica spectrum disorder

Journal of Neuroinflammation, 2021
Background and purpose Neuromyelitis optica spectrum disorder (NMOSD) is mainly an anti-aquaporin 4 (anti-AQP4) autoantibodies-mediated idiopathic inflammatory demyelinating disease of the central nervous system. Systemic and local inflammatory responses
Xue Ma, Chuan Qin, Man Chen, Hai-Han Yu, Yun-Hui Chu, Ting-Jun Chen, Dale B. Bosco, Long-Jun Wu, Bi-Tao Bu, Wei Wang, Dai-Shi Tian   +10 more
doaj   +1 more source