Results 171 to 180 of about 30,314 (226)

Reduced-Symmetry Homoleptic Pd₂L₄ Cages Stabilized by Noncovalent π-Interactions. [PDF]

Chemistry
Poole DA, Zhang B, Bobylev EO, Mathew S, Reek JNH.   +4 more
europepmc   +1 more source

Structural and functional dissection of the WH2/DAD motif of INF2, a formin linked to human inherited degenerative disorders

The FEBS Journal, EarlyView.
The INF2 WH2/DAD domain, composed of hydrophobic and basic regions, forms a single α‐helix in solution. The hydrophobic segment is essential for INF2 function, as its deletion disrupts actin dynamics and causes nuclear abnormalities, like those seen in pathogenic INF2 DID variants. In contrast, natural INF2 WH2/DAD variants found in patients with renal
Leticia Labat‐de‐Hoz, Laura Fernández‐Martín, Paula Morales, Isabel Correas, María Ángeles Jiménez, Miguel Angel Alonso   +5 more
wiley   +1 more source

Periplasmic protein quality control at atomic level in live cells. [PDF]

Nat Commun
González LJ, Hita FJ, Pontoriero L, Pierattelli R, Binolfi A, Vila AJ.   +5 more
europepmc   +1 more source

Structural investigation of human U6 snRNA recognition by spliceosomal recycling factor SART3 RNA recognition motifs

The FEBS Journal, EarlyView.
Human SART3 has two RRM domains to engage with U6 snRNA for spliceosome recycling. This study reports solution structures of SART3 RRM domains and investigates the interaction between RRM and U6 snRNA. SART3 binds to the asymmetric bulge of U6 snRNA as a dimer via conserved positively charged surfaces.
Iktae Kim, Kyeong‐Mi Bang, So Young An, Changkon Park, Ji‐Yeon Shin, Youngim Kim, Hyun Kyu Song, Jeong‐Yong Suh, Nak‐Kyoon Kim   +8 more
wiley   +1 more source

Investigating a Systematic and Widespread Misidentification in the Metabolic Profiling Literature: Phenylacetylglutamine and Phenylacetylglycine Signal Misassignment in Proton NMR Spectra of Human and Rodent Urine. [PDF]

Anal Chem
Sala S, Bernal A, Castillo Robles A, Nitschke P, Masuda R, Kadyrov J, Posma JM, Elliott P, Lindon JC, Wilson ID, Holmes E, Wist J, Nicholson JK.   +12 more
europepmc   +1 more source

Expanding the substrate scope of a bacterial monoterpene synthase for the production of sesquiterpenoid and diterpenoid products

The FEBS Journal, EarlyView.
We have converted the only known true bacterial monoterpene synthase, cineole synthase from Streptomyces clavuligerus (bCinS, C10 substrate), to a highly competent sesquiterpene synthase (C15) with a minimum number of rational mutations. By comparison with diterpene synthases (C20), we were then able to bestow diterpene synthase activity on bCinS. This
Nicole G. H. Leferink, Joshua N. Whitehead, Linus O. Johannissen, Nigel S. Scrutton   +3 more
wiley   +1 more source

Structural Basis for HIV-1 Maturation Inhibition by PF-46396 Determined by MAS NMR. [PDF]

J Am Chem Soc
Zadorozhnyi R, Quinn CM, Zadrozny KK, Ablan SD, Kennedy BJ, Yap GPA, Sanner D, Kraml C, Freed EO, Ganser-Pornillos BK, Pornillos O, Gronenborn AM, Polenova T.   +12 more
europepmc   +1 more source

Characterisation of a phylogenetically distinct PL25 family ulvan lyase from a seaweed biomass enriched metagenome

The FEBS Journal, EarlyView.
Ulvan is a polysaccharide available from green seaweed with beneficial properties for various applications. The full potential of ulvan requires enzymatic degradation of the polymer, thus producing ulvan oligosaccharides. This study expands the armoury of characterised ulvan lyases.
Andrius Jasilionis, Pavithra Sivakumar, Justyna M. Dobruchowska, Sune Fjermedal, Hörður Guðmundsson, Bjorn Thor Adalsteinsson, Guðmundur Ó. Hreggviðsson, Anne S. Meyer, Eva Nordberg Karlsson   +8 more
wiley   +1 more source

Structural Characterization and Multiomics Analysis Reveal Extensive Diversity and Global Distribution of Kurstakin Lipopeptides. [PDF]

J Nat Prod
Campbell R, Mevers E.
europepmc   +1 more source

Brain tissue classification in hyperspectral images using multistage diffusion features and transformer

Journal of Microscopy, EarlyView.
Abstract Brain surgery is a widely practised and effective treatment for brain tumours, but accurately identifying and classifying tumour boundaries is crucial to maximise resection and avoid neurological complications. This precision in classification is essential for guiding surgical decisions and subsequent treatment planning.
Neetu Sigger, Tuan T. Nguyen, Gianluca Tozzi   +2 more
wiley   +1 more source