Results 71 to 80 of about 309,964 (310)

Dynamic Nuclear Polarization NMR Spectroscopy: Revealing Multiple Conformations in Lipid-Anchored Peptide Vaccines

, 2013
Sensitivity is the key: Dynamic nuclear polarization NMR spectroscopy provides structural information on liposomal vaccines targeting Alzheimer's disease. DMPC/DMPG/Cholesterol mainly stabilizes extended structures of the lipid-anchored peptide, while in
Koers, E.J., López-Deber, M.P., Muhs, A., Reis, P., Nand, D., Sub NMR Spectroscopy, Granet, A., NMR Spectroscopy, Baldus, M., Mlaki Ndao, D., Weingarth, M.H., Pfeifer, A., Hickman, D.T.   +12 more
core   +1 more source

Electro‐Steric Ion Confinement in Polyelectrolyte Networks for Robust Nonvolatile Artificial Synapse

Advanced Functional Materials, EarlyView.
Polyelectrolyte stoichiometry governs ion transport and retention in electrolyte‐gated synaptic transistors. A PSS‐rich network creates electro‐steric ion confinement that suppresses ion back‐diffusion and stabilizes channel doping, enabling robust nonvolatile synaptic memory, linear weight updates, and low‐energy operation.
Donghwa Lee, Jinbo Kim, Myeongjin An, Jisoo Park, Junho Sung, Eunsung Hwang, Suhwan Seok, Seong‐Min Bak, Jeonghun Kim, Eunho Lee   +9 more
wiley   +1 more source

Diagnostic performance of a multi-shell DTI protocol and its subsets with B-matrix spatial distribution correction in differentiating early multiple sclerosis patients from healthy controls

Frontiers in Neurology
IntroductionThis study investigates whether a multi-shell diffusion tensor imaging (DTI) protocol and its subsets can reliably distinguish healthy controls (HC) from patients with multiple sclerosis (MS) presenting with low Expanded Disability Status ...
Artur Tadeusz Krzyzak, Artur Tadeusz Krzyzak, Julia Lasek, Julia Lasek, Agnieszka Slowik   +4 more
doaj   +1 more source

Solid-state NMR on complex biomolecules: Methods and applications [PDF]

, 2018
Solid-state NMR (ssNMR) can provide structural information at the most detailed level and, at the same time, is applicable in highly heterogeneous and complex molecular environments, largely irrespective of solubility or crystallinity.
Baldus, Marc, NMR Spectroscopy, Sub NMR Spectroscopy, Weingarth, Markus, Mance, Deni, Webb, Graham A., Marc Baldus, Markus Weingarth, Deni Mance   +8 more
core   +1 more source

Blood Biomarkers and Surface‐Enhanced Raman Spectroscopy for Gout: A Comprehensive Review

Advanced Functional Materials, EarlyView.
Schematic illustrating gout disease progression from asymptomatic hyperuricemia to chronic tophaceous disease, highlighting the limitations of conventional imaging and biochemical diagnostics and the potential of engineered SERS platforms for ultrasensitive blood‐based detection of urate‐related biomarkers across disease stages, with the color gradient
Isuri Perera, Chiranjeevi Kanike, Appurva Tiwari, Hongyan Wu, Larry D. Unsworth, Ben Bin Xu, Xuehua Zhang   +6 more
wiley   +1 more source

Selective Membrane Transport Systems studied by Solid-State NMR Spectroscopy

, 2009
Membranes border cells from their environment. Thus, they belong to the basic prerequisites for life as we know it. Within cells, membranes are used to establish compartments dedicated to specific tasks such as providing local proximity of components ...
Ader, C., NMR Spectroscopy, NMR-spectroscopie, Sub NMR Spectroscopy   +3 more
core  

An Efficient Labelling Approach to Harness Backbone and Side-Chain Protons in 1H-Detected Solid-State NMR Spectroscopy [PDF]

, 2015
1H-detection can greatly improve spectral sensitivity in biological solid-state NMR (ssNMR), thus allowing the study of larger and more complex proteins.
Sinnige, Tessa, Daniëls, Mark, Baldus, Marc, NMR Spectroscopy, Sub NMR Spectroscopy, Narasimhan, Siddarth, Weingarth, Markus, Mance, Deni, Kaplan, M., Houben, Klaartje   +9 more
core   +1 more source

Application of Ibuprofen Sodium Dihydrate for Thermochemical Energy Storage

Advanced Functional Materials, EarlyView.
Ibuprofen sodium dihydrate is introduced as a durable organic salt hydrate for low‐temperature thermochemical energy storage, operating within 60°C–110°C with high energy density. At the material level, it delivers ∼99.9% cycling efficiency over 150 cycles without deliquescence, enabled by a dual energy‐storage mechanism coupling dehydration and phase ...
Kavin Chakravarthy Thangaraj, Hannah F. Chang, Shannon J. Lee, Mark E. Bowden, J. David Bazak, Vaithiyalingam Shutthanandan, Venkateshkumar Prabhakaran, Xiao Zhang, David M. Reed, Ajay S. Karakoti, Vijayakumar Murugesan   +10 more
wiley   +1 more source

T1- and diffusion tensor-based fractal dimension of white and grey matter in multiple sclerosis

Frontiers in Neurology
IntroductionMultiple sclerosis (MS) changes brain microstructure even at early disease stages, with changes detectable in normal-appearing white matter (NAWM) and grey matter (GM).
Weronika Mazur-Rosmus, Zofia Schneider, Agnieszka Słowik, Artur Tadeusz Krzyżak   +3 more
doaj   +1 more source

Multifunctional Gold Nanocluster‐Based PROTAC System for Targeted Degradation of Phosphorylated Tau and Modulation of Neuroinflammation in Alzheimer's Disease

Advanced Functional Materials, EarlyView.
We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins, Callan D. McLoughlin, Wan‐Kyu Ko, Hye Kyu Choi, Brandon Conklin, Joshua B. Stein, Yannan Hou, Hongwon Kim, Rohan Khulbe, Ki‐Bum Lee   +9 more
wiley   +1 more source