Results 41 to 50 of about 7,937 (163)

Phase I Evaluation of Siltartoxatug, a First‐in‐Class Anti‐Tetanus Monoclonal Antibody: Safety, Pharmacokinetics and Pharmacodynamics in Healthy Australian and Chinese Populations

Clinical Pharmacology &Therapeutics, EarlyView.
Siltartoxatug, a first‐in‐class monoclonal antibody targeting tetanus toxin for post‐exposure prophylaxis, was evaluated in two phase I trials in Australian and Chinese healthy adults. In these randomized, double‐blind, placebo‐controlled, dose‐escalation studies, participants received a single intramuscular injection of siltartoxatug (10–250 μg/kg) or
Xinyu Liu, Zhigang Liu, Xiaohu Kuang, Yueming Wang, Xiaoyi Liu, Jiyuan Ding, Xia Zhou, Xin Zhou, Qianyu Liang, Meizhuo Zhang, Hao Zhao, Qingqing Tan, Weihong Zheng, Huaxin Liao, Charlotte Lemech, Wanmei Wang   +15 more
wiley   +1 more source

Toxicity and Hypolipidemic Activity of Lansiumamide B in Mice [PDF]

Shipin Kexue
Objective: To explore the hypolipidemic activity and toxic side effect of lansiumamide B (LB) from chicken-heart shaped wampee (Clausena lansium) seeds in C57BL/6J mice fed on a high-fat-diet (HFD) model.
CHEN Danni, WANG Sainan, YIN Zhaochun, XU Zewen, GUO Xiaomin, LI Kangyuan, WANG Jiawei, CHEN Liping, CAO Yong, XIAO Suyao
doaj   +1 more source

The Governance Gap: Democratizing Drug Development Through Decision Architecture

Clinical Pharmacology &Therapeutics, EarlyView.
Drug development is most exposed to governance failure where it can least afford it, in global health. The field has more predictive power than at any point in its history and roughly the same failure rate it had a decade ago. We argue that this paradox persists because the field has invested heavily in prediction science while neglecting decision ...
Craig R. Rayner, Nancy E. Martin, Danielle Smith, Eliza Kruger, Carl M.J. Kirkpatrick, Goonaseelan (Colin) Pillai, Katy Moore, Darrell Nix, Cristina Donini, Jakob P. Cramer, Edmundo Muniz, Natalia Muniz, Ernst Bos, Douglas McNair, Shyam Bhaskaran, Mark Sullivan, Dan Hartman   +16 more
wiley   +1 more source

In vitro and in vivo toxicological evaluation of 6′-Sialyllactose sodium salt produced by a novel method

Toxicology Reports
6′-Sialyllactose (6′-SL) sodium salt is the sodium salt of a naturally occurring trisaccharide found in dairy products and human milk. 6′-SL sodium salt formulations produced by different methods have been the subject of other safety studies and are ...
Rit B. Gurung, Laurie C. Dolan, Benjamin G. Arceneaux, Hiroe Go, Eun Jung Park   +4 more
doaj   +1 more source

Safety evaluation of enriched fraction from leaves of Dillenia indica L. in BALB/c mice

Toxicology Reports, 2022
The enriched fraction derived from Dillenia indica L. (Dilleniaceae), also known as elephant apple was subjected to acute and sub-acute toxicological study to document its safety issues for use as fumigant. The enriched fractions were orally administered
Kabrambam D. Singh, Sarita Jena, Biswajit Patra, Thiyam B. Devi, Saurabh Chawla, Rupjyoti Bharali, Ajay Parida, Pulok K. Mukherjee, Yallappa Rajashekar   +8 more
doaj   +1 more source

From Prediction to Decision Making: PBPK and QSP as Regulatory‐Grade NAMs

Clinical Pharmacology &Therapeutics, EarlyView.
New approach methodologies (NAMs) encompass a diverse and rapidly evolving set of experimental and computational tools designed to generate human‐relevant mechanistic data for use in drug development and regulatory decision making. Experimental NAMs provide insights into drug disposition, pharmacological activity, and disease biology that are difficult
Karen Rowland Yeo, Piet H. van der Graaf
wiley   +1 more source

Origin of Physicochemical and Mechanical Stability of Low‐Temperature Prepared TiO2‐Based Photocatalytic Films: Surface Hydroxyl Density Matching

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Material science advances show how surface chemistry improves low‐temperature prepared TiO2‐SiO2 composite films. Using a colloidal‐based synthesis method instead of a powdered‐based one, researchers exploit hydroxyl groups' interfacial interactions to create nanoscale structures with superior physicochemical and mechanical stability.
Andraž Šuligoj, Mohamad El‐Roz, Goran Dražić, Frédéric Thibault‐Starzyk, Pegie Cool, Nataša Zabukovec Logar, Urška Lavrenčič Štangar, Nataša Novak Tušar   +7 more
wiley   +1 more source

Effects of Oxalic Acid on Apis mellifera (Hymenoptera: Apidae)

Insects, 2017
: Oxalic acid dihydrate is used to treat varroosis of Apis mellifera. This study investigates lethal and sublethal effects of oxalic acid dihydrate on individually treated honeybees kept in cages under laboratory conditions as well as the distribution in
Eva Rademacher, Marika Harz, Saskia Schneider   +2 more
doaj   +1 more source

Toxicological Evaluation of Kenaf Seed Supercritical Carbon Dioxide-Oil in Male Sprague Dawley Rats

ASM Science Journal, 2021
Kenaf seed supercritical carbon dioxide oil (KSO-SFE) is known for its numerous health benefits such as high antioxidant activity, lower plasma cholesterol level, chemopreventive to cervical and colon cancer.
Siti Aisyah Abd Ghafar, Latifah Saiful Yazan, Sharida Fakhurazi, Maznah Ismail   +3 more
doaj   +1 more source

Safety Evaluation for Restorin® NMN, a NAD+ Precursor

Frontiers in Pharmacology, 2021
NAD+ is an abundant molecule in the body and vital to all living cells. NAD+ levels decline with age, and this decline correlates with age-related diseases. Therefore, sustaining NAD+ levels offers potential benefits to healthspan and longevity.
John Turner, Albert Licollari, Emil Mihalcea, Aimin Tan   +3 more
doaj   +1 more source