Results 71 to 80 of about 7,937 (163)

Dose‐Related Gastric Toxicity of Diethyl Phthalate in Female Wistar Rats

Journal of Applied Toxicology, Volume 46, Issue 11, Page 4242-4254, November 2026.
ABSTRACT Diethyl phthalate (DEP) is commonly used in cosmetics, personal care products, and pharmaceutical formulations as a low‐molecular‐weight phthalate. Despite its widespread use, information on its effects on the gastric mucosa remains limited. This study examined the dose‐related effects of DEP on inflammation, oxidative stress, gastric mucosal ...
Gul Sahika Gokdemir, Mehmet Cihan Yavaş, Selim Demirtaş, Fazile Cantürk Tan, Salih Varol, Mehmet Tahir Gokdemir   +5 more
wiley   +1 more source

Safety assessment of Superba™ krill powder: Subchronic toxicity study in rats

Toxicology Reports, 2015
The safety of krill powder was assessed in a subchronic 13-week toxicity study where rats were fed krill powder or control diets. The krill powder inclusion in the test diet was 9.67% (w/w).
Kjetil Berge, Bruce Robertson, Lena Burri   +2 more
doaj   +1 more source

Clinical outcomes of intratumoural para‐toluenesulfonamide treatment in equine melanoma

Equine Veterinary Education, Volume 38, Issue 11, Page e821-e829, November 2026.
Summary Equine melanoma is one of the most common cutaneous neoplasms in horses and is particularly prevalent in grey horses. Although these tumours often demonstrate indolent biological behaviour, some progressively develop locally invasive or malignant characteristics over time, making treatment decisions challenging in clinical practice.
H.‐C. Lo, H. Yan‐Der, P.‐L. Chang, M.‐Y. Lin, S. Kee   +4 more
wiley   +1 more source

First‐in‐human, phase I, randomized, safety, pharmacokinetic, food‐effect and pharmacodynamic study of a tyrosine kinase 2/Janus kinase 1 inhibitor, SDC‐1801

British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3513-3526, October 2026.
Aim The purpose of this study is to evaluate safety, tolerability, pharmacokinetics (PK), food‐effect (FE) and pharmacodynamics (PD) of an oral tyrosine kinase‐2 (TYK2)/Janus kinase‐1 (JAK1) inhibitor, SDC‐1801, in healthy adult participants. Methods This first‐in‐human study randomized 95 male and female participants.
Chris Brearley, Sam Francis, John Reader, Judi Proctor   +3 more
wiley   +1 more source

Developmental Toxicity Study for the Antimalarial Drug Combination Cabamiquine‐Pyronaridine Using a Translational Approach

Birth Defects Research, Volume 118, Issue 10, October 2026.
ABSTRACT Background The safety of pharmacological treatments during pregnancy is a significant concern, as many medications lack comprehensive reproductive safety data. This creates gaps in therapeutic options for pregnant women, particularly malaria, which poses serious risks to maternal and fetal health.
Wookyung Kim, Geum‐Sil Cho, Andreas Gado, Tobias Hyun Ho Baeurle, Habib Karimi, Filippo Venezia, Claude Oeuvray, Thomas Spangenberg, Sebastian G. Wicha, Claudia Demarta‐Gatsi   +9 more
wiley   +1 more source

Pharmacokinetics, Immunogenicity, and Safety of a Modified YTE Antibody in Healthy Adults

Clinical Pharmacology in Drug Development, Volume 15, Issue 10, October 2026.
Abstract REGN17092, a fully human immunoglobulin (Ig) G1 antibody with M252Y/S254T/T256E (YTE) modification in the Fc portion, was assessed in a first‐in‐human study (ClinicalTrials.gov, NCT05923424). REGN17092 was designed to target the severe acute respiratory coronavirus 2 (SARS‐CoV‐2) S protein.
Maria Rosario, Jan de Hoon, Flonza Isa, Kenneth Turner, Jing Li, Joel Kantrowitz, Samit Ganguly, Sasha Fraser, Zhongqing Will He, Hong Yan, Ana Gonzalez Ortiz, Lori Faria, Ingeborg Heirman, Alina Baum, Thomas D Norton, Yogesh Patel, Veronica Mas Casullo, John D Davis   +17 more
wiley   +1 more source

Plant Part–Specific Differences in Ashwagandha (Withania somnifera): A Comparative Evaluation of Root and Leaf Evidence for Safety and Regulation

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
This review contrasts the root and leaf of Withania somnifera (ashwagandha) across phytochemistry, clinical evidence, and regulatory context. Root preparations are dominated by withanolide A, D, and glyco‐withanolides, with multiple randomized controlled trials supporting reductions in stress, anxiety, and insomnia alongside a favorable safety profile.
Abhijit Dutta, Jang Bahadur Gupta
wiley   +1 more source

Immunomodulatory Properties of Withania somnifera: Regulation of Innate Immune Cells and Clinical Implications

Phytotherapy Research, Volume 40, Issue 10, Page 5951-5972, October 2026.
ABSTRACT Withania somnifera (L.) Dunal (WS), commonly known as Ashwagandha, is a prominent medicinal herb in Ayurveda, with extensive therapeutic potential attributed to its diverse phytochemical profile. This review critically examines the immunomodulatory properties of WS, focusing on innate immune cell populations, including neutrophils, eosinophils,
Rana Yukta, Sonalika Gupta, Gagandeep Kaur, Partha Sarathi Mondal, Milirani Das, Anagha Ranade, Alok Kumar Srivastava, Sachin Kumar, Manoj Kumar Barthwal, Madhu Dikshit   +9 more
wiley   +1 more source

Assessment of Monomer Release From Resin Composites Following the Use of Various Modeling Liquids

Journal of Esthetic and Restorative Dentistry, Volume 38, Issue 10, Page 1933-1946, October 2026.
ABSTRACT Objectives The chemical composition of resin composites and the use of modeling liquids may influence the release of residual monomer, potentially impacting biocompatibility. This in vitro study evaluated the effect of different modeling liquids on the elution of monomers from two resin composites.
Dorukcan Yıldırım, Hüseyin Hatırlı, Emine Şirin Karaarslan, Tarık Balkan   +3 more
wiley   +1 more source

Lyophilized B. subtilis ZB183 Spores: 90-Day Repeat Dose Oral (Gavage) Toxicity Study in Wistar Rats

Journal of Toxicology, 2019
A 90-day repeated-dose oral toxicological evaluation was conducted according to GLP and OECD guidelines on lyophilized spores of the novel genetically modified strain B. subtilis ZB183.
B. Appala Naidu, Kamala Kannan, D. P. Santhosh Kumar, John W. K. Oliver, Zachary D. Abbott   +4 more
doaj   +1 more source