Results 121 to 130 of about 1,583,705 (314)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Expanding the Donor Pool with Living Donors [PDF]

Progress in Transplantation, 2001
openaire   +2 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

OCCULT BLOODSTREAM INFECTION IN LIVER DONORS: FREQUENCY, ETIOLOGY AND IMPACT ON RECIPIENTS IN TWO TRANSPLANT CENTERS

Brazilian Journal of Infectious Diseases
Introduction: Donor-derived infections in organ recipients are infrequent but associated with high morbidity and mortality. Reported frequencies of occult bloodstream infection (BSI) among organ donors range from 5 to 21%.
Luiz Felipe de Abreu Guimarães, Tainara Moreira Curcio, Larissa de Oliveira Pereira, Claudia Cristina Tavares de Sousa, Eduardo de Souza Martins Fernandes, Guilherme Santoro Lopes   +5 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Incidence and clinical relevance of donor-derived recipient-specific anti-HLA antibodies in haploidentical hematopoietic stem cell transplantation: a retrospective study

Cell Transplantation
Donor-derived recipient-specific anti-HLA antibodies (RSAs) are rarely investigated in allogeneic hematopoietic stem cell transplantation (allo-HSCT). In this retrospective study, 185 haploidentical donor-recipient pairs were consecutively analyzed. Anti-
Xianbo Huang, Yanling Ren, Shasha Wang, Chen Mei, Yu Xu, Jie Jin, Hongyan Tong, Jiejing Qian   +7 more
doaj   +1 more source

Report on living liver donor risk and outcomes: Single center experience

Transplantation Reports
Introduction Donor hepatectomy is considered as a major surgical procedure and can lead to severe complications. Since 2012, 64 deceased donor liver transplantation (DDLT) and 420 living donor liver transplantation were performed in Kazakhstan.
Jamilya Saparbay, Abylaikhan Sharmenov, Chokhan Aytbayev, Assylmurat Zhumukov, Bekkhozha Yeskendirov, Zhanat Spatayev, Asan Zhexembayev   +6 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source