Results 221 to 230 of about 1,885,648 (256)
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Regulatory Toxicology and Pharmacology, 1996
Data on chronic toxicity are generally required to derive a health-based acceptable exposure limit, such as the acceptable daily intake. However, only acute and/or subacute toxicity data are available for many compounds. In this study, we assessed conversion factors (CFs) to estimate a chronic no-observed-adverse-effect-level (NOAELchronic) from these ...
Kramer, HJ +3 more
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Data on chronic toxicity are generally required to derive a health-based acceptable exposure limit, such as the acceptable daily intake. However, only acute and/or subacute toxicity data are available for many compounds. In this study, we assessed conversion factors (CFs) to estimate a chronic no-observed-adverse-effect-level (NOAELchronic) from these ...
Kramer, HJ +3 more
openaire +3 more sources
Experimental Pathology, 1989
Four methods for intra- and inter-species dose extrapolation for inhalation reference doses are discussed. Dichloromethane is used as an example to illustrate quantitative differences in the methods. The methods include a procedure recommended by the U.S.
J H, Overton, A M, Jarabek
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Four methods for intra- and inter-species dose extrapolation for inhalation reference doses are discussed. Dichloromethane is used as an example to illustrate quantitative differences in the methods. The methods include a procedure recommended by the U.S.
J H, Overton, A M, Jarabek
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Statistical issues on the determination of the no‐observed‐adverse‐effect levels in toxicology
Environmetrics, 2001AbstractThe determination of a safe exposure level for toxic agents, often defined as the highest dose level with no toxic effect and termed the no‐observed‐adverse‐effect level (NOAEL) is reviewed. The conventional methods based on statistical tests are criticized, particularly when the sample size is small, and an alternative method, which is based ...
Takashi Yanagawa, Yasuki Kikuchi
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Regulatory Toxicology and Pharmacology, 2003
In a double blind, 3x3 factorial (volumexdose) study, 70 adult females (18-60 years of age) at four different international sites (total pooled n=269) were given 100, 150, or 200ml of bottled drinking water with 0.4, 0.8, or 1.2mg of copper (Cu) as the sulfate salt once each week.
Araya, Magdalena +11 more
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In a double blind, 3x3 factorial (volumexdose) study, 70 adult females (18-60 years of age) at four different international sites (total pooled n=269) were given 100, 150, or 200ml of bottled drinking water with 0.4, 0.8, or 1.2mg of copper (Cu) as the sulfate salt once each week.
Araya, Magdalena +11 more
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Critical Reviews in Toxicology, 2016
Although consumption of chrysotile asbestos has decreased since the 1970s, the latency period of asbestos-related cancers is thought to be at least 20-30 years, and therefore the potential health risks associated with historical exposures is still actively researched.
Jennifer S, Pierce +2 more
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Although consumption of chrysotile asbestos has decreased since the 1970s, the latency period of asbestos-related cancers is thought to be at least 20-30 years, and therefore the potential health risks associated with historical exposures is still actively researched.
Jennifer S, Pierce +2 more
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Journal of Allergy and Clinical Immunology, 2006
Current labeling practices for allergenic foods like peanut can be inadequate. For future regulatory and industry guidelines, information on no-observed-adverse-effect levels (NOAELs) and eliciting doses (EDs) for allergenic foods is necessary.To determine NOAEL and ED in a representative group of peanut-sensitized children, relate these data to ...
Annebeth E, Flinterman +8 more
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Current labeling practices for allergenic foods like peanut can be inadequate. For future regulatory and industry guidelines, information on no-observed-adverse-effect levels (NOAELs) and eliciting doses (EDs) for allergenic foods is necessary.To determine NOAEL and ED in a representative group of peanut-sensitized children, relate these data to ...
Annebeth E, Flinterman +8 more
openaire +2 more sources
Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation, 2020
The purpose of this study was to investigate the NOAEL of the nickel ion and provide with basic data for the biological evaluation of those medical devices containing nickel. Five groups SD rats were repeatedly exposed during 14 d respectively to nickel at first stage doses of 4.9, 3.7, 2.5 mg/(kg.d), and the second stage doses of 1.2, 0.25 mg/(kg.d ...
Xueying, He +9 more
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The purpose of this study was to investigate the NOAEL of the nickel ion and provide with basic data for the biological evaluation of those medical devices containing nickel. Five groups SD rats were repeatedly exposed during 14 d respectively to nickel at first stage doses of 4.9, 3.7, 2.5 mg/(kg.d), and the second stage doses of 1.2, 0.25 mg/(kg.d ...
Xueying, He +9 more
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Nigerian Journal of Animal Production
There is the need to determine the no observed adverse effect level and no observed effect level (NOAEL and NOEL) of fipronil using haematological indices and liver markers of albino rats as recent trend in development of resistance by pests may lead to increasing the quantity of fipronil required to control them. Acute toxicity of fipronil (Terminator"
V. U. OMOJA +4 more
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There is the need to determine the no observed adverse effect level and no observed effect level (NOAEL and NOEL) of fipronil using haematological indices and liver markers of albino rats as recent trend in development of resistance by pests may lead to increasing the quantity of fipronil required to control them. Acute toxicity of fipronil (Terminator"
V. U. OMOJA +4 more
openaire +1 more source