Results 41 to 50 of about 823,854 (211)

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

UNUSUAL OPPORTUNISTIC INFECTION AFTER LUNG TRANSPLANT: CASE REPORT OF NOCARDIA CYRIACIGEORGICA PNEUMONIA

Brazilian Journal of Infectious Diseases
Introduction: Nocardia infection is an increasing concern in solid organ transplant recipients due to prolonged immunosuppression. A relatively uncommon and underrecognized pathogen, Nocardia infections pose several challenges, from diagnosis to clinical
Caian L Vinhaes
doaj   +1 more source

Comprehensive evaluation of metagenomic next‐generation sequencing for pathogen identification in patients with suspected infection: Establishment of a standardized validation workflow

VIEW, EarlyView.
Comprehensive evaluation of metagenomic next‐generation sequencing for pathogen identification in patients with suspected infection: Establishment of a standardized validation workflow. Abstract Metagenomic next‐generation sequencing (mNGS) enables unbiased identification of pathogens directly from clinical specimens. Despite its growing application in
Wen Shu, Qiaomei Guo, Han Yang, Huiqin Jiang, Chunyan He, Xueqing Wang, Yuting Fang, Yue Yin, Liwen Zhong, Zhijing Zhao, Jiatao Lou, Lin Wang   +11 more
wiley   +1 more source

Nocardia Brain Abscess In A Patient With Advanced HIV-AIDS: Case Report

Journal of Rawalpindi Medical College, 2023
Nocardia is a gram-positive bacterium that causes localised and disseminated infections. A rare case of Nocardia infection in an immunocompromised individual is presented.
Muhammad Usman, Valeed Bin Mansoor, Nasim Akhtar , Muhammad Arqam Miraj   +3 more
doaj   +1 more source

Cerebral Abscess Infected by Nocardia gipuzkoensis

Infection and Drug Resistance, 2023
Nocardia gipuzkoensis is a novel species that solely identified in patients with pulmonary infections by far. Growing evidence showed the excellent performance of metagenomics next-generation sequencing (mNGS) on pathogenic identification, especially for new species. Here, we described the first case of an elderly female patient suddenly suffering from
Li X, Feng Y, Li D, Chen L, Shen M, Li H, Li S, Wu X, Lu L   +8 more
openaire   +3 more sources

16S/18S metabarcoding versus culture for aetiological assessment in infectious keratitis: A prospective paired‐sample study

Acta Ophthalmologica, EarlyView.
Abstract Purpose Infectious keratitis (IK) is a vision‐threatening condition with diverse microbial aetiologies, yet conventional culture‐based diagnostics often have limited sensitivity. We investigated whether 16S/18S rRNA amplicon‐based next‐generation sequencing (NGS) can enhance aetiological assessment when used alongside standard microbiological ...
Sandra M. Skovdal, Christen Rune Stensvold, Henrik Vedel Nielsen, Stine Elkjær Nielsen, Jesper Hjortdal, Lise Kristensen, Anders Ivarsen   +6 more
wiley   +1 more source

Die ungewöhnliche Infektion: Femoralabszess durch Nocardia bei einem Patienten mit metastasierendem peripheren Bronchialcarcinom und hygienische Konsequenzen

, 2011
During the course of a peripheral bronchial carcinoma with pulmonary and cerebral metastases a femoral abscess developed in a 49 year-old patient after radio- and chemotherapy.
Schaal, KP, Fetouh Yassin, AA, Franke, A, Daeschlein, G, Kramer, A   +4 more
core   +1 more source

Diagnosis and treatment of hydrocephalus caused by intracranial Nocardia infection: a case report and review of the literature

Brain Disorders
Background: Nocardia infections typically occur in the lungs and skin, with pulmonary involvement being the most common. However, dissemination to other body parts, including the central nervous system (CNS), is not uncommon.
Shuang-Qi Gao, Jian-Wei Huang, Ying Guo
doaj   +1 more source

Nocardia infection following phacoemulsification

Indian Journal of Ophthalmology, 2007
Infection of a self-sealing tunnel incision is a rare but vision-threatening complication of cataract surgery. We describe two cases of side port infection following an uneventful phacoemulsification. Nocardia was isolated in one case. Both the cases were worsening on medical treatment and were successfully treated by therapeutic keratoplasty.
Gokhale Nikhil, Garg Prashant, Rodrigues Camila, Haldipurkar Suhas   +3 more
openaire   +3 more sources

Ocular and cutaneous infection due to Curvularia pseudobrachyspora in an immunosuppressed dog: Case report and in vitro antimycotic susceptibilities

Australian Veterinary Journal, EarlyView.
A 3‐year‐old male Border Collie diagnosed with immune‐mediated dermatopathy, managed with tapering prednisolone and cyclosporine, developed rapidly progressive ocular signs and additional cutaneous lesions. Histopathology, mycological culture, polymerase chain reaction and sequencing confirmed intraocular and cutaneous infection due to Curvularia ...
T Brasil‐Ervedosa, R Clark, J Granados‐Soler, C Palmieri, V Gonzalez‐Astudillo   +4 more
wiley   +1 more source