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Annual Review of Pharmacology and Toxicology, 2023 Adverse nocebo responses can cause harm to patients and interfere with treatment adherence and effects in both clinic practice and clinical trials. Nocebo responses refer to negative outcomes to active medical treatments in clinical trials or practice that cannot be explained by the treatment's pharmacologic effects.
L. Colloca
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Differential Classical Conditioning of the Nocebo Effect: Increasing Heat-Pain Perception without Verbal Suggestions [PDF]
Frontiers in Psychology, 2017 Background: Nocebo effects, including nocebo hyperalgesia, are a common phenomenon in clinical routine with manifold negative consequences. Both explicit expectations and learning by conditioning are known to induce nocebo effects, but the specific role ...
Anne-Kathrin Bräscher +7 more
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Nocebo hyperalgesia and the startle response [PDF]
Neuroscience, 2016 The literature on the effects of nocebo on pain is sparse. The present experimental study investigated whether suggestions of nocebo hyperalgesia modified the startle response and whether increased startle contributed to the nocebo hyperalgesic effect.A design with four groups was employed; the participants were randomized into either a placebo group ...
Per M. Aslaksen +3 more
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A Direct Comparison of Placebo and Nocebo Effects on Visuospatial Attention: An Eye-Tracking Experiment [PDF]
Frontiers in Psychiatry, 2019 Background: Placebo and nocebo effects on visual attention are still poorly understood. This eye-tracking study directly compared effects of sham transcranial magnetic stimulation (sTMS) that was administered along with the verbal suggestion that the ...
Carina Höfler +2 more
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Nocebos contribute to host of ills
International Journal of Trauma Nursing, 1996 HERBERT BENSON, MD, still recalls the time a patient nearly made him sick. The incident happened during his internship, as Benson was about to examine an Asian man. When the patient came into the examining room, Benson says he "absolutely panicked." In a cold sweat, his heart racing, the physician performed the exam. But afterward, he told the patient
R Voelker
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Risk factors associated with nocebo effects: A review of reviews
Brain, Behavior, & Immunity - HealthObjective: This meta-review aims to identify and categorize the risk factors that are associated with nocebo effects. The nocebo effect can exert a negative impact on treatment outcomes and have detrimental outcomes on health.
Francesca Grosso +4 more
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Nocebo Effects and Scratching Behaviour on Itch [PDF]
Acta Dermato-Venereologica, 2018 Nocebo effects, i.e. reduced treatment effects due to patients’ negative expectations, play a role in itch. Recent studies have shown that nocebo effects can be induced experimentally on itch and also be minimized and even turned into the opposite ...
Danielle J.P. Bartels +3 more
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Acta Dermato-Venereologica, 2021 To investigate learning processes underlying nocebo effects on itch, this study measured the efficacy of classical conditioning and observational learning for inducing nocebo effects on cowhage-evoked itch and scratching behaviour.
Joseph S. Blythe +6 more
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Placebo and Nocebo Effects Across Symptoms: From Pain to Fatigue, Dyspnea, Nausea, and Itch [PDF]
Frontiers in Psychiatry, 2019 Placebo and nocebo effects are, respectively, the helpful and harmful treatment effects that do not arise from active treatment components. These effects have thus far been researched most often in pain.
Fabian Wolters +6 more
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A systematic review of sex differences in the placebo and the nocebo effect
Journal of Pain Research, 2017 Sara M Vambheim,1 Magne Arve Flaten2 1Department of Psychology, UiT, The Arctic University of Norway, Tromsø, 2Department of Psychology, Norwegian University of Science and Technology (NTNU), Trondheim, Norway Objectives: The present review ...
Vambheim SM, Flaten MA
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