Results 1 to 10 of about 11,304 (209)

Nocebo effects are stronger and more persistent than placebo effects in healthy individuals [PDF]

eLife
Placebo and nocebo effects illustrate the profound influence of cognitive-affective processes on symptom perception and treatment outcomes, with the potential to significantly alter responses to medical interventions.
Angelika Kunkel, Katharina Schmidt, Helena Hartmann, Torben Strietzel, Jens-Lennart Sperzel, Katja Wiech, Ulrike Bingel   +6 more
doaj   +2 more sources

Minimizing Drug Adverse Events by Informing About the Nocebo Effect—An Experimental Study

Frontiers in Psychiatry, 2019
Relevance: Informing patients about potential adverse events as part of the informed consent may facilitate the development of nocebo-driven drug adverse events (nocebo side effects).Objective: To investigate whether informing about the nocebo effect ...
Yiqi Pan, Yvonne Nestoriuc
exaly   +3 more sources

Placebo and nocebo in clinical practice: An online cross-sectional survey of healthcare professionals from European countries on views, practices and training needs. [PDF]

PLoS ONE
BackgroundPlacebo and nocebo effects significantly influence health outcomes, yet healthcare professionals receive limited training and guidance on their mechanisms and clinical application, creating a gap in education and practical understanding ...
Mary O'Keeffe, Nathan Skidmore, Arianna Bagnis, Przemysław Bąbel, Elżbieta A Bajcar, Alessandra De Palma, Andrea W M Evers, Eveliina Glogan, Julia W Haas, Stefanie H Meeuwis, Marek Oleszczyk, Antonio Portolés, Johan W S Vlaeyen, Katia Mattarozzi, PANACEA Consortium   +14 more
doaj   +2 more sources

How Negative Experience Influences the Brain: A Comprehensive Review of the Neurobiological Underpinnings of Nocebo Hyperalgesia

Frontiers in Neuroscience, 2021
This comprehensive review summarizes and interprets the neurobiological correlates of nocebo hyperalgesia in healthy humans. Nocebo hyperalgesia refers to increased pain sensitivity resulting from negative experiences and is thought to be an important ...
Mia A. Thomaidou, Mia A. Thomaidou, Kaya J. Peerdeman, Kaya J. Peerdeman, Melissa I. Koppeschaar, Andrea W. M. Evers, Andrea W. M. Evers, Andrea W. M. Evers, Andrea W. M. Evers, Dieuwke S. Veldhuijzen, Dieuwke S. Veldhuijzen   +10 more
doaj   +1 more source

Temporal structure of brain oscillations predicts learned nocebo responses to pain

Scientific Reports, 2021
This study aimed to identify electrophysiological correlates of nocebo-augmented pain. Nocebo hyperalgesia (i.e., increases in perceived pain resulting from negative expectations) has been found to impact how healthy and patient populations experience ...
Mia A. Thomaidou, Joseph S. Blythe, Simon J. Houtman, Dieuwke S. Veldhuijzen, Antoinette I. M. van Laarhoven, Andrea W. M. Evers   +5 more
doaj   +1 more source

A randomized pharmacological fMRI trial investigating d-cycloserine and brain plasticity mechanisms in learned pain responses

Scientific Reports, 2022
Learning and negative outcome expectations can increase pain sensitivity, a phenomenon known as nocebo hyperalgesia. Here, we examined how a targeted pharmacological manipulation of learning would impact nocebo responses and their brain correlates ...
Mia A. Thomaidou, Joseph S. Blythe, Dieuwke S. Veldhuijzen, Kaya J. Peerdeman, Johan (Hans) P. A. van Lennep, Erik J. Giltay, Henk R. Cremers, Andrea W. M. Evers   +7 more
doaj   +1 more source

No evidence that attentional bias towards pain-related words is associated with verbally induced nocebo hyperalgesia: a dot-probe study

PAIN Reports, 2021
. Introduction:. Placebo and nocebo effects in pain are well documented. One leading explanation is that instructions indicating that pain will either increase or decrease after receipt of a treatment give rise to expectations for increased or decreased ...
Matthew James Coleshill, Louise Sharpe, Ben Colagiuri   +2 more
doaj   +1 more source

Adverse drug reactions associated with amitriptyline - protocol for a systematic multiple-indication review and meta-analysis [PDF]

, 2020
Background: Unwanted anticholinergic effects are both underestimated and frequently overlooked. Failure to identify adverse drug reactions (ADRs) can lead to prescribing cascades and the unnecessary use of over-thecounter products.
Brueckle, Maria-Sophie, Gerlach, Ferdinand M, Glasziou, Paul P, Gonzalez-Gonzalez, Ana Isabel, Harder, Sebastian, Muth, Christiane, Nguyen, Truc Sophia, Pilz, Maximilian, Seide, Svenja E, Thomas, Elizabeth T   +9 more
core   +1 more source

Counterconditioning as Treatment to Reduce Nocebo Effects in Persistent Physical Symptoms: Treatment Protocol and Study Design

Frontiers in Psychology, 2022
Persistent physical symptoms have a high prevalence and a large impact for patients and society. To date, treatment effects for these symptoms are often limited.
Simone Meijer, Simone Meijer, Henriët van Middendorp, Henriët van Middendorp, Kaya J. Peerdeman, Kaya J. Peerdeman, Andrea W. M. Evers, Andrea W. M. Evers, Andrea W. M. Evers, Andrea W. M. Evers   +9 more
doaj   +1 more source

Unethical informed consent caused by overlooking poorly measured nocebo effects [PDF]

, 2020
Unlike its friendly cousin the placebo effect, the nocebo effect (the effect of expecting a negative outcome) has been almost ignored. Epistemic and ethical confusions related to its existence have gone all but unnoticed.
Howick, Jeremy
core   +1 more source