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The role of learning in nocebo and placebo effects
Acute Pain, 2008The nocebo effect consists in delivering verbal suggestions of negative outcomes so that the subject expects clinical worsening. Here we show that nocebo suggestions, in which expectation of pain increase is induced, are capable of producing both hyperalgesic and allodynic responses. By extending previous findings on the placebo effect, we investigated
Colloca L +2 more
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Pain and the Placebo/Nocebo Effect
2011In the last 20 years, placebo and nocebo research has provided scientific ground for a phenomenon once believed to be only patient mystification, or at best a variable to control in clinical trials. Neurochemical, pharmacological and neuroimaging studies are elucidating the mechanisms by which the activation of identifiable neural pathways produces ...
POLLO, Antonella, BENEDETTI, Fabrizio
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2016
Placebo refers to the positive expectation that a treatment will help patients, and nocebo refers to adverse events related to patient’s negative expectations that a medical treatment will likely harm instead of healing. Both conditions illustrate the power of human brain and are strongly related to treatment outcome and adherence. Placebos and nocebos
Christina I. Deligianni +1 more
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Placebo refers to the positive expectation that a treatment will help patients, and nocebo refers to adverse events related to patient’s negative expectations that a medical treatment will likely harm instead of healing. Both conditions illustrate the power of human brain and are strongly related to treatment outcome and adherence. Placebos and nocebos
Christina I. Deligianni +1 more
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Placebo and Nocebo Effects in Itch and Pain
2014Physical complaints, such as pain, can be effectively altered by placebo and nocebo effects due to induction of positive or negative expectations. While verbal suggestion and conditioning are recognized as playing a key role in placebo and nocebo effects on pain, these mechanisms have barely been investigated with regard to other somatosensory ...
Danielle J. P. Bartels +5 more
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The Power of Labeling in Nocebo Effects
2018Nocebo effects comprise two broad types: primary nocebo effects, in which overall treatment efficacy is reduced; and nocebo side effects, which result in the increased experience of unpleasant secondary side effects. An important factor in generating nocebo effects of both types is the patient's expectations of how well a treatment will work, and how ...
Kate Faasse, Leslie R. Martin
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Placebo, Nocebo, and Learning Mechanisms
2014Recent substantial laboratory and theoretical research hints for different learning mechanisms regulating the formation of placebo and nocebo responses. Moreover, psychological and biological variants may play a role as modulators of learning mechanisms underlying placebo and nocebo responses. In this chapter, we present pioneering and recent human and
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2019
Placebo and nocebo effects are two phenomena that play an important role in clinical research and can significantly impact the outcomes of clinical research which in turn can impact clinical care for our patients.
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Placebo and nocebo effects are two phenomena that play an important role in clinical research and can significantly impact the outcomes of clinical research which in turn can impact clinical care for our patients.
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Headaches and the Nocebo Effect
Headache: The Journal of Head and Face Pain, 2003Malcolm P. Rogers, Randolph W. Evans
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