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Placebo and nocebo phenomena from the perspective of evidence based and person centered medicine [PDF]

Hospital Pharmacology, 2017
Introduction: Placebo and nocebo phenomena in pharmacology are very important, but controversial issues from the perspective of evidence-based medicine (EBM) in many ways.
Jakovljević Miro I.
doaj   +1 more source

Resisting Contagious Hopelessness: Therapeutic Alliance and the Limits of Physician‐Assisted Death in Severe and Enduring Anorexia Nervosa

Psychiatric Research and Clinical Practice, EarlyView.
Contemporary psychiatric ethics emphasize autonomy and shared decision‐making, yet these frameworks may be strained in severe mental illnesses characterized by cognitive rigidity, fluctuating decisional capacity, and undue clinician influence. Severe and enduring anorexia nervosa serves as a case example to explore how therapeutic alliance, clinician ...
Elizabeth M. Olson, Fabian M. Saleh, Angela S. Guarda   +2 more
wiley   +1 more source

Dispositional optimism and open‐label placebo responses in hair cortisol concentrations and psychological distress—A randomized controlled trial

Applied Psychology: Health and Well-Being, Volume 18, Issue 5, October 2026.
Abstract Open‐label placebo (OLP) treatments show beneficial effects on various health‐related outcomes, but studies investigating OLP effects on physiological measures remain scarce. This randomized controlled trial examined the effect of a 4‐week OLP intervention on psychological distress and hair cortisol concentrations (HCC) in 202 healthy ...
Carolin Liedtke, Michael Schaefer, Sören Enge   +2 more
wiley   +1 more source

No Reason to Feel Sick? Nocebo Responses in the Placebo Arms of Experimental Endotoxemia Studies

Frontiers in Psychiatry, 2019
Adverse side effects are reported by a large proportion of patients undergoing medical treatment in clinical practice or clinical trials. Nocebo effects, induced by negative treatment expectancies, can contribute to negative patient-reported outcomes but
Sven Benson, Sigrid Elsenbruch
doaj   +1 more source

The Nocebo Effect

Annual Review of Pharmacology and Toxicology
Adverse nocebo responses can cause harm to patients and interfere with treatment adherence and effects in both clinic practice and clinical trials. Nocebo responses refer to negative outcomes to active medical treatments in clinical trials or practice that cannot be explained by the treatment's pharmacologic effects.
openaire   +2 more sources

Short‐Term Effect of Negative Verbal Language Versus Positive Verbal Language on Physical and Functional Capacity and Pain in People With Chronic Primary Low Back Pain

European Journal of Pain, Volume 30, Issue 8, September 2026.
ABSTRACT Background Low back pain (LBP) is the leading cause of years lived with disability. While education is recommended by most guidelines, the type of language used can lead to a placebo or nocebo effect. This study aims to compare the short‐term effect of negative language versus positive language on physical and functional capacity in ...
Yves Schwendenmann, Pierre‐Antoine Palacios, Martin Descarreaux, Andrée‐Anne Marchand   +3 more
wiley   +1 more source

Evidence for Cognitive Placebo and Nocebo Effects in Healthy Individuals [PDF]

, 2018
Inactive interventions can have significant effects on cognitive performance. Understanding the generation of these cognitive placebo/nocebo effects is crucial for evaluating the cognitive impacts of interventional methods, such as non-invasive brain ...
Mittner, Matthias, Luisa Gunkel, Turi, Z, Zsolt Turi, Antal, Andrea, Paulus, Walter, Matthias Mittner, Bjørkedal, Espen, Turi, Zsolt, Andrea Antal, Gunkel, Luisa, Espen Bjørkedal, Walter Paulus   +12 more
core   +2 more sources

Mapping Pain Memory Across Modalities: Distinct Spatial Representations of Recalled Visceral and Somatic Pain

European Journal of Pain, Volume 30, Issue 8, September 2026.
ABSTRACT Background Representation of pain areas offers a spatial dimension of pain perception, yet it has rarely been used in the context of visceral pain. This experimental study examined spatial patterns of acute visceral and somatic pain and their recall.
Catrin Guddat, Genisius Hartanto, Robert J. Pawlik, Thomas Graven‐Nielsen, Sigrid Elsenbruch, Jana L. Aulenkamp   +5 more
wiley   +1 more source

Media-Induced Nocebo Effects

, 2021
Full Text is available to authenticated members of The University of Auckland only.The nocebo effect is a powerful phenomenon with important implications in healthcare. Social modelling is one of the influencing mechanisms of the nocebo effect.
Rankin, Sarah
core  

Placebo and nocebo effects on itch: An experimental approach [PDF]

, 2020
Placebo and nocebo effects are positive or negative treatment effects respectively, unrelated to the treatment mechanism, which are induced by patients’ expectations.
Bartels, D.J.P.
core