Results 211 to 220 of about 70,074 (346)

Contributions of synaptic energetic dysfunction by microtubule dynamics and microtubule‐based mitochondrial transport disorder to morphine tolerance

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 17, Page 4058-4079, September 2025.
Abstract Background and Purpose Morphine is among the most powerful analgesic, but its long‐term use can cause tolerance. Synaptic ATP supply is critical for maintaining synaptic transmission. Microtubule‐based mitochondrial transport ensures synaptic energy supply.
Zheng Li   +9 more
wiley   +1 more source

Skin Biopsy as a Diagnostic Tool for ATTRv Amyloid Neuropathy in the UK

open access: yesJournal of the Peripheral Nervous System, Volume 30, Issue 3, September 2025.
ABSTRACT Objective Gene silencing therapy for ATTRv has revolutionised treatment. In minimally symptomatic, early neuropathic disease, skin biopsy can aid in the diagnosis of ATTRv‐PN, assessing both amyloid deposition and IENFD. Our aim was to study the value of performing skin biopsies in the diagnosis of ATTRv‐PN in UK patients and to assess the ...
Luke F. O'Donnell   +10 more
wiley   +1 more source

The Proteinase-Activated Receptor 2 Is Involved in Nociception

open access: hybrid, 2001
Willemijntje A. Hoogerwerf   +8 more
openalex   +1 more source

Endothelins contribute towards nociception induced by antigen in ovalbumin‐sensitised mice [PDF]

open access: green, 2004
Anna Paula Piovezan   +5 more
openalex   +1 more source

Pharmacological Targeting of Hyperpolarization‐Activated Cyclic Nucleotide‐Gated Cation Channels on Bladder Afferent Sensory Transmission

open access: yesLUTS: Lower Urinary Tract Symptoms, Volume 17, Issue 5, September 2025.
ABSTRACT Objective This study aimed to investigate the potential role of cesium chloride (CsCl), ivabradine (IVA), and isoproterenol (ISO) on the sensory transmission of bladder afferents to graded urinary bladder distension (UBD). We specifically selected these drugs to target the hyperpolarization‐activated cyclic nucleotide‐gated (HCN) cation ...
Eric Woon   +5 more
wiley   +1 more source

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