ABSTRACT Background Mechanical detection thresholds (MDTs) are used to assess somatosensory function but can only be evaluated considering the individual sex, age and tested body region. The German Research Network on Neuropathic Pain (DFNS) provides reference values for OptiHair2, a sensitive and expensive glass filament, while nylon filaments such as
Jan D. Wandrey+7 more
wiley +1 more source
Mapping Morphine's Antinociceptive Impact on the Ventral Tegmental Area During Nociceptive Stimulation: A Novel Microimaging Approach in a Neuropathic Pain Model. [PDF]
Ganaway A+10 more
europepmc +1 more source
Evidence for chemical nociception in the small intestine that is not mediated via mechanoreceptors
Bárbara Schmidt+3 more
openalex +1 more source
A Novel Investigation of an In‐Scanner Alternative to the Cold Pressor Test in Healthy Individuals
We propose cold gelled‐water paradigm as the closest in‐scanner alternative to the cold pressor task for healthy individuals. Using ICA, seed‐based connectivity and spDCM, we reveal descending pain control engagement, PAG‐cortical functional disengagement and dynamic connectivity changes, offering new insights into the neural mechanisms of tonic cold ...
Sonia Medina, Sam W. Hughes
wiley +1 more source
Differential regulation of bladder pain and voiding function by sensory afferent populations revealed by selective optogenetic activation [PDF]
DeBerry, Jennifer J+7 more
core +1 more source
Decitabine‐Driven Foetal Haemoglobin Induction in Townes Mice and Human Erythroblasts
ABSTRACT Background Induction of foetal haemoglobin (HbF) is a clinically validated approach to modulate the severity of sickle cell disease (SCD). This manuscript evaluates the efficacy of decitabine, a DNA methyltransferase (DNMT) inhibitor, in inducing HbF in healthy human erythroblasts and Townes mice, which are well‐established systems modelling ...
Ariadna Carol Illa+6 more
wiley +1 more source
Neural substrates of cold nociception in <i>Drosophila</i> larva. [PDF]
Patel AA, Cardona A, Cox DN.
europepmc +1 more source
Clinical and magnetic resonance imaging characteristics of thoracolumbar intervertenral disk extrusions and protrusions in large breed dogs [PDF]
Beltran, E+5 more
core +1 more source