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Pharmacological Reviews, 2001
The study of pain in awake animals raises ethical, philosophical, and technical problems. We review the ethical standards for studying pain in animals and emphasize that there are scientific as well as moral reasons for keeping to them.
D. Bars, M. Gozariu, S. Cadden
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The study of pain in awake animals raises ethical, philosophical, and technical problems. We review the ethical standards for studying pain in animals and emphasize that there are scientific as well as moral reasons for keeping to them.
D. Bars, M. Gozariu, S. Cadden
semanticscholar +1 more source
Ion Channels Involved in Substance P-Mediated Nociception and Antinociception
International Journal of Molecular Sciences, 2019 Substance P (SP), an 11-amino-acid neuropeptide, has long been considered an effector of pain. However, accumulating studies have proposed a paradoxical role of SP in anti-nociception.
Chu-Ting Chang, Chih-Cheng Chen
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Intraoperative Nociception Monitoring
Anesthesiology Clinics, 2021Nociception refers to the process of encoding and processing noxious stimuli. Its monitoring can have potential benefits. Under anesthesia, nociceptive signals are continuously generated to cause involuntary effects on the autonomic nervous system, reflex movement, and stress response. Most available systems depend on the identification and measurement
Harsha, Shanthanna +2 more
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Depth of Anesthesia and Nociception Monitoring: Current State and Vision For 2050.
Anesthesia and AnalgesiaAnesthesia objectives have evolved into combining hypnosis, amnesia, analgesia, paralysis, and suppression of the sympathetic autonomic nervous system. Technological improvements have led to new monitoring strategies, aimed at translating a qualitative ...
Pascal Laferrière-Langlois +5 more
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Polymodal Nociception in Drosophila Requires Alternative Splicing of TrpA1
Current Biology, 2019 Transcripts of noxious stimulus-detecting TrpA1 channels are alternatively spliced. Despite the importance of nociception for survival, the in vivo significance of expressing different TrpA1 isoforms is largely unknown.
Pengyu Gu, Jiaxin Gong, Fei Wang
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Photoplethysmography and nociception
Acta Anaesthesiologica Scandinavica, 2009Photoplethysmography (PPG), i.e. pulse oximetric wave, is a non‐invasive technique that is used in anaesthesia monitoring primarily to monitor blood oxygenation. The PPG waveform resembles that of the arterial blood pressure but instead of pressure it is related to the volume changes in the measurement site and hence contains information related to the
I, Korhonen, A, Yli-Hankala
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Neuropharmacology, 2019
Background: Recent discovery of mechanosensitive Piezo receptors in trigeminal ganglia suggested the novel molecular candidate for generation of migraine pain.
N. Mikhailov +9 more
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Background: Recent discovery of mechanosensitive Piezo receptors in trigeminal ganglia suggested the novel molecular candidate for generation of migraine pain.
N. Mikhailov +9 more
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Minerva Anestesiologica, 2019
INTRODUCTION Under-dosage or over-dosage of intraoperative analgesia can cause harm to patients. Many studies have demonstrated the clinical advantages of nociception monitoring tools, but with some conflicting results.
Yang Jiao +5 more
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INTRODUCTION Under-dosage or over-dosage of intraoperative analgesia can cause harm to patients. Many studies have demonstrated the clinical advantages of nociception monitoring tools, but with some conflicting results.
Yang Jiao +5 more
semanticscholar +1 more source
Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1985
There is evidence that the cerebral cortex is involved in the perception of pain but no specific area appears to be the ‘pain centre’. Limited knowledge exists on the cortical processing of the noxious input. The nociceptors are most likely to activate at least two different systems with different characteristics.
S A, Andersson, B, Rydenhag
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There is evidence that the cerebral cortex is involved in the perception of pain but no specific area appears to be the ‘pain centre’. Limited knowledge exists on the cortical processing of the noxious input. The nociceptors are most likely to activate at least two different systems with different characteristics.
S A, Andersson, B, Rydenhag
openaire +2 more sources
Current Opinion in Neurobiology, 1991
In recent years, progress in the treatment of pain has been strongly influenced by new insights into the mechanisms underlying pain and nociception. The following article briefly reviews some recent reports which make a significant contribution to our knowledge of the structure and function of nocisensors, the neuropeptides involved in the nociceptive ...
B, Heppelmann +3 more
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In recent years, progress in the treatment of pain has been strongly influenced by new insights into the mechanisms underlying pain and nociception. The following article briefly reviews some recent reports which make a significant contribution to our knowledge of the structure and function of nocisensors, the neuropeptides involved in the nociceptive ...
B, Heppelmann +3 more
openaire +2 more sources