Results 261 to 270 of about 70,074 (346)

Molecular Mechanisms of Chronic Pain and Therapeutic Interventions

MedComm, Volume 6, Issue 8, August 2025.
We offer a comprehensive overview of the distinctive molecular mechanisms underlying nociceptive, neuropathic, and nociplastic pain, including the immune responses, ion channels, monoaminergic imbalance, and neuroinflammation. Subsequently, we summarized the status quo of nociceptive, neuropathic, and nociplastic pain managementmanipulation.
Zhen Li, Xing Li, Jieqiong Liu, Rao Sun, Yingze Ye, Hongbing Xiang, Fang Luo, Shiyong Li, Ailin Luo   +8 more
wiley   +1 more source

Functional Characterization of a Novel Intronic Variant in PIEZO2 in a Recessive Form of Distal Arthrogryposis With Impaired Proprioception and Touch (DAIPT)

Molecular Genetics &Genomic Medicine, Volume 13, Issue 8, August 2025.
DAIPT is a rare genetic disease caused by PIEZO2 gene mutations. We identified two novel variants of the gene, a nonsense and an intronic substitution, in a child with suspected DAIPT. Functional studies confirmed the effect of the nonsense variant and demonstrated the pathogenicity of the intronic one by providing a conclusive diagnosis of DAIPT. This
Michela Bellardita, Ferruccio Romano, Ludovica Menta, Joana Soraia Martinheira Da Silva, Marzia Ognibene, Simona Baldassari, Marco Di Duca, Chiara Panicucci, Serena Baratto, Noemi Brolatti, Marina Pedemonte, Chiara Fiorillo, Claudio Bruno, Marcello Scala, Federico Zara, Francesca Faravelli, Francesca Madia, Serena Cappato, Renata Bocciardi, Valeria Capra   +19 more
wiley   +1 more source

An α-1,3-fucosyltransferase influences thermal nocifensive escape behaviors in <i>Drosophila</i> larvae. [PDF]

MicroPubl Biol
Ballard S, Holt L, Stant E, Arthur Moore A, Zavala L, Shirangi T.   +5 more
europepmc   +1 more source

A Unified Explanation for Drug Repurposing and Pharmacological Pleiotropy Based on Classical and Statistical Thermodynamics

Pharmacology Research &Perspectives, Volume 13, Issue 4, August 2025.
ABSTRACT Drug repurposing is an authentic, emerging, and growing aspect of drug development when the demand for new therapeutic solutions is high. Many repurposed drugs have been discovered by serendipity or a non‐ordered process driven by chance and sharp observation.
Richard Head, Saiful Islam, Jennifer H. Martin   +2 more
wiley   +1 more source

Photoplethysmography parameters in monitoring nociception during general anesthesia. [PDF]

BMC Anesthesiol
Li H, Tang Y, Chen X, Zhang M, Jiang F, Zhu F, Xie L, Wu H, Xu Q, Chen Q, Xie S, Dai A, Chen X.   +12 more
europepmc   +1 more source

Gene Expression Shifts in Emperor Penguin Adaptation to the Extreme Antarctic Environment

Molecular Ecology, Volume 34, Issue 15, August 2025.
ABSTRACT Gene expression can accelerate ecological divergence by rapidly tweaking the response of an organism to novel environments, with more divergent environments exerting stronger selection and supposedly, requiring faster adaptive responses. Organisms adapted to extreme environments provide ideal systems to test this hypothesis, particularly when ...
Josephine R. Paris, Flávia A. Nitta Fernandes, Federica Pirri, Samuele Greco, Marco Gerdol, Alberto Pallavicini, Marine Benoiste, Clément Cornec, Lorenzo Zane, Brian Haas, Céline Le Bohec, Emiliano Trucchi   +11 more
wiley   +1 more source

The heating rate matters! contact heat evoked potentials in musicians and non-musicians. [PDF]

Front Pain Res (Lausanne)
Sternkopf F, Scheuren PS, Jutzeler CR, Lee A.   +3 more
europepmc   +1 more source

Enteric neuropathy and the vagus nerve: Therapeutic implications

Neurogastroenterology &Motility, Volume 37, Issue 8, August 2025.
Abstract Enteric neuropathies are characterized by abnormalities of gut innervation, which includes the enteric nervous system, inducing severe gut dysmotility among other dysfunctions. Most of the gastrointestinal tract is innervated by the vagus nerve, the efferent branches of which have close interconnections with the enteric nervous system and ...
Bruno Bonaz
wiley   +1 more source

An approach to targeting Nav1.7 for pain sensations. [PDF]

J Clin Invest
Cummins TR.
europepmc   +1 more source