Results 151 to 160 of about 97,568 (259)

Plant‐Derived Bioactives and PPAR Signaling in Functional Dyspepsia: Mechanistic Insights and Therapeutic Perspectives

Phytotherapy Research, EarlyView.
Functional dyspepsia involves duodenal barrier dysfunction, low‐grade immune activation and altered neuroimmune signalling. Various plant‐derived bioactives may modulate PPAR signalling, reduce inflammatory and oxidative stress, and support epithelial, immune, metabolic, and sensory homeostasis.
Irene Palenca, Emidio Scarpellini, Jan Tack, Pierluigi De Pierro, Giovanni Sarnelli, Giuseppe Esposito   +5 more
wiley   +1 more source

Piezo1 in Peripheral and Central Sensitisation: Implications for Chronic Pain. [PDF]

Bioengineering (Basel)
Kopach O.
europepmc   +1 more source

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source

Mixed pain: has pain medicine overlooked Its most common phenotype for over 20 years? A perspective on mechanistic interaction, the nociplastic paradox, and the future of pain classification. [PDF]

Front Med (Lausanne)
Freynhagen R, Alcántara Montero A.
europepmc   +1 more source

Sensory profile of cats with potential pain‐related diabetic neuropathy

Veterinary Record, EarlyView.
Abstract Background Diabetes mellitus (DM) can cause peripheral neuropathy. This study aimed to evaluate sensory function by measuring the mechanical nociceptive thresholds (MNT) and diffuse noxious inhibitory control (DNIC) of cats with diabetes mellitus (DMcats).
Hélène L. M. Ruel, Vanessa Bruneau, Berenice Conversy, Sabrine Marangoni, Paulo V. Steagall   +4 more
wiley   +1 more source

Pain Mechanisms in Fibromyalgia: An Integrative Narrative Review of Central, Peripheral, Neuroimmune, and Psychobiological Factors. [PDF]

Biomedicines
Martins-Alves F, Almeida A.
europepmc   +1 more source

Single‐dose enflicoxib versus a 7‐day course of firocoxib for postoperative pain control in dogs undergoing orthopaedic surgery: A multicentre, randomised, masked, non‐inferiority study

Veterinary Record, EarlyView.
Abstract Background Perioperative analgesia is essential in dogs undergoing orthopaedic surgery, and enflicoxib's long duration makes single‐dose administration attractive. Methods A prospective, multicentre, randomised, masked trial compared enflicoxib (8 mg/kg) given 24 hours before surgery with firocoxib (5 mg/kg) given daily for 7 days. Two hundred
Marta Salichs, José I. Redondo, Anabel Blasco‐Moreno, Llorenç Badiella, Josep Homedes   +4 more
wiley   +1 more source

International Consensus Definition of Mixed Pain: A Commentary on Freynhagen et al. Regarding the Mixed Pain Concept. [PDF]

Eur J Pain
Attal N.
europepmc   +1 more source

EEG FREQUENCY-TAGGING TO DETERMINE WHETHER THE CORTICAL PROCESSING OF NOCICEPTIVE AND NON-NOCICEPTIVE SOMATOSENSORY INPUT INVOLVES DISTINCT NEURONAL POPULATIONS.

, 2013
Whether the cortical processing of nociceptive input relies on the activity of nociceptive-specific neurons or whether it relies on the activity of non-specific neuronal populations remains a matter of intense debate. Here, we address this question using
Colon, Elisabeth, Neural Circuits of Pain, Legrain, Valéry, Mouraux, André   +3 more
core  

Perioperative analgesia and postoperative motor function after saphenous and sciatic nerve blocks in goats undergoing bilateral stifle surgery: A pilot study

Veterinary Record, EarlyView.
Abstract Background The combination of femoral and sciatic nerve blocks offers adequate perioperative analgesia for goats undergoing stifle surgery. However, postoperatively, residual motor dysfunction may lead to distress and discomfort. This study evaluated whether combined saphenous and sciatic nerve blocks provide adequate perioperative analgesia ...
Xavier Torruella, Claire Loughran, Flavia Restitutti, Joei Potter, Margot C. Labberté, Pieter A. J. Brama, Vilhelmiina Huuskonen   +6 more
wiley   +1 more source