Results 191 to 200 of about 39,802 (268)

Anterior Cervical Discectomy and Fusion Modulates Inflammatory Factors and Pain Mediators in Cervical Disc Herniation With Neurogenic Pain

Orthopaedic Surgery, Volume 18, Issue 4, Page 745-754, April 2026.
This study demonstrates that ACDF significantly reduces inflammatory factors and pain mediators, improves clinical symptoms and neuroelectrophysiological outcomes in cervical disc herniation with neurogenic pain, with comparable safety to conservative treatment.
Bing Wu, Xin He, Hongzhen Jiang, Xiujie Yan, Jun An, Xiaojin Guo, Xiaodong Pang, Baogan Peng   +7 more
wiley   +1 more source

Molecular architecture of human dermal sleeping nociceptors. [PDF]

Cell
Körner J, Howard D, Solinski HJ, Mancilla Moreno M, Haag N, Fiebig A, Maxion A, Bhuiyan SA, Toklucu I, Bott RA, Sankaranarayanan I, Tavares-Ferreira D, Shiers S, Inturi NN, Eberhardt E, Ernst L, Bonaguro L, Schulte-Schrepping J, Beyer MD, Stiehl T, Renthal W, Kurth I, Tigerholm J, Serra J, Price TJ, Schmelz M, Namer B, Tripathy S, Lampert A.   +28 more
europepmc   +1 more source

GABAB receptor‐mediated modulation of sensory neuron excitability: Roles of CaV2.2, G‐protein‐coupled inwardly rectifying potassium (GIRK) channels, and hyperpolarisation‐activated cyclic nucleotide‐gated (HCN) channels in human and mouse nociception

Experimental Physiology, Volume 111, Issue 4, Page 2026-2043, 1 April 2026.
Abstract Chronic visceral pain is a key symptom of irritable bowel syndrome. Modulation of voltage‐gated calcium and potassium channels by G protein‐coupled receptors plays a key role in dampening nociceptive transmission. Both baclofen and the analgesic peptide α‐conotoxin Vc1.1 activate GABAB receptors (GABABR), resulting in inhibition of CaV2.2 and ...
Mariana Brizuela, Anuja R. Bony, Sonia Garcia‐Caraballo, David J. Adams, Stuart M. Brierley   +4 more
wiley   +1 more source

Targeting Na_v Channels for Pain Relief: Structural Insights and Therapeutic Opportunities. [PDF]

Int J Mol Sci
Xie Y, Huang X, Lu F, Huang J.
europepmc   +1 more source

The Excelsatoxin A‐Receptor TMEM233 Modulates Nav1.8

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
TMEM233 is a largely uncharacterized transmembrane protein that enables the sensitivity of Nav1.8 to Excelasatoxin A, a naturally occurring peptide that can significantly reduce the fast inactivation of this ion channel (left) expressed in sensory neurons or different cell lines. Moreover, its presence enhances the use dependent block of Nav1.8 induced
George Oprita, Marvin J. A. Meyer, Daniel Rudolf, Inês C. A. Pombeiro Stein, Jennifer R. Deuis, Hue N. T. Tran, Thomas Durek, Klasfauseweh Tabea, Jami Sina, Stephen G. Waxman, Sulayman D. Dib‐Hajj, Alexandru Babes, Irina Vetter, Andreas Leffler   +13 more
wiley   +1 more source

Mitogen- and stress-activated kinase 1 in primary sensory neurons contributes to formalin-induced tonic pain. [PDF]

Pain Rep
Irfan J, Febrianto RM, La Montanara P, Meng MY, Hutson TH, Zimmermann D, Deak-Pocsai K, Aldossary D, Wang J, Di Giovanni S, Kress M, Nagy I.   +11 more
europepmc   +1 more source

Osteoarthritis: molecular pathogenesis and potential therapeutic options. [PDF]

Signal Transduct Target Ther
Zhang Y, Han Y, Sun Y, Hao L, Gao Y, Ye J, Wang H, Zhang T, Liu Y, Yang Y.   +9 more
europepmc   +1 more source

Genetic identification of mouse trigeminal afferents responsible for mechanical allodynia. [PDF]

Cell Rep
Li T, Son H, Arora V, Shannonhouse J, Kumari S, Chang D, Caterina M, Kim YS, Chung MK.   +8 more
europepmc   +1 more source

Decoding Pain: Next-Generation In Vitro Systems for Mechanistic Insights and Drug Discovery. [PDF]

FASEB J
Khosrowshahi D, Lagae L, Bolander J.
europepmc   +1 more source

Nonspecific lower back pain in overhead athletes is multifactorial and is not solely determined by the type and intensity of the sport. [PDF]

S Afr J Sports Med
Finsterer J.
europepmc   +1 more source