Results 191 to 200 of about 22,526 (252)

Mitogen- and stress-activated kinase 1 in primary sensory neurons contributes to formalin-induced tonic pain. [PDF]

Pain Rep
Irfan J, Febrianto RM, La Montanara P, Meng MY, Hutson TH, Zimmermann D, Deak-Pocsai K, Aldossary D, Wang J, Di Giovanni S, Kress M, Nagy I.   +11 more
europepmc   +1 more source

Decoding Pain: Next-Generation In Vitro Systems for Mechanistic Insights and Drug Discovery. [PDF]

FASEB J
Khosrowshahi D, Lagae L, Bolander J.
europepmc   +1 more source

Targeting Na_v Channels for Pain Relief: Structural Insights and Therapeutic Opportunities. [PDF]

Int J Mol Sci
Xie Y, Huang X, Lu F, Huang J.
europepmc   +1 more source

Genetic identification of mouse trigeminal afferents responsible for mechanical allodynia. [PDF]

Cell Rep
Li T, Son H, Arora V, Shannonhouse J, Kumari S, Chang D, Caterina M, Kim YS, Chung MK.   +8 more
europepmc   +1 more source

Osteoarthritis: molecular pathogenesis and potential therapeutic options. [PDF]

Signal Transduct Target Ther
Zhang Y, Han Y, Sun Y, Hao L, Gao Y, Ye J, Wang H, Zhang T, Liu Y, Yang Y.   +9 more
europepmc   +1 more source

Ultrasensitive proteomics uncovers nociceptor diversity and novel pain targets

Chakrabarti S, Makhmut A, Mohammadi A, Luo W, Wang L, Lewin GR, Coscia F.   +6 more
europepmc   +1 more source

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Neurotrophins, nociceptors, and pain

Microscopy Research and Technique, 1999
It is now well established that neurotrophins play a crucial role in the development of the nervous system. However, there is increasing evidence that the function of neurotrophins persists throughout adulthood. The broad scope of neurotrophin action is well documented in the case of nerve growth factor (NGF) and its effect on nociceptors and ...
L M, Mendell, K M, Albers, B M, Davis
openaire   +2 more sources

Nociceptors for the 21st Century

Current Review of Pain, 2000
This review summarizes recent developments in the context of the neurochemical classification of nociceptors and explores the relationships between functionally and neurochemically defined subgroups. Although the complete picture is not yet available, several lines of intriguing evidence suggest that despite the complexity and diversity of nociceptor ...
Alvarez, Francisco J., Fyffe, Robert E.W.   +1 more
openaire   +4 more sources

Neurotrophins, nociceptors and pain

Current Opinion in Anaesthesiology, 2000
Nerve growth factor (NGF) is known to play a key role in the development of hyperalgesia after inflammatory injury. The increased levels of NGF that accompany injury lead to hyperalgesia via peripheral and central spinal mechanisms. New evidence reviewed here indicates that NGF can directly sensitize nociceptive neurones to noxious heat stimuli through
P A, Heppenstall, G R, Lewin
openaire   +2 more sources

Nociceptor plasticity: A closer look

Journal of Cellular Physiology, 2017
Nociceptors are receptors specifically involved in detecting a tissue damage and transducing it in an electrical signal. Nociceptor activation provoked by any kind of acute lesion is related to the release of several mediators of inflammation, within the framework of a process defined as “peripheral sensitization.” This results in an exaggerated ...
PACE, Maria Caterina, PASSAVANTI, Maria Beatrice, De Nardis, Lorenzo, Bosco, Fabio, SANSONE, Pasquale, Pota, Vincenzo, BARBARISI, Manlio, PALAGIANO, Antonio, Iannotti, Fabio Arturo, Panza, Elisabetta, AURILIO, Caterina   +10 more
openaire   +5 more sources