Results 181 to 190 of about 39,802 (268)

Psychedelic Therapies for Comorbid Major Depressive Disorder and Chronic Pain: A Review of Putative Mechanisms of Action

Pharmacology Research &Perspectives, Volume 14, Issue 2, April 2026.
ABSTRACT Major Depressive Disorder (MDD) and chronic pain are independently debilitating conditions that frequently co‐occur. This comorbidity poses a significant clinical challenge, resulting in greater symptom severity, higher disability, and worse prognosis than either condition alone.
Jordana Kazdan, Karim S. Ladha, M. Ishrat Husain   +2 more
wiley   +1 more source

Co-cultured sensory neuron classification using extracellular electrophysiology and machine learning approaches for enhancing analgesic screening. [PDF]

J Neural Eng
Somers A, Black BJ.
europepmc   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Impaired touch sensation on hairy skin in HCN3-deficient mice. [PDF]

Front Neurosci
Metzner K, Hussein-Zahovic T, Behery Y, Fenske S, Biel M, Schmidtko A.   +5 more
europepmc   +1 more source

The Evolutionary Biology of Female‐Biased Pain and Its Disorders

Evolutionary Applications, Volume 19, Issue 4, April 2026.
ABSTRACT This article describes and evaluates a general evolutionary theory for explaining variation among individuals in sensitivity to pain, the Vulnerability‐Value‐Opportunity model. The model posits that pain sensitivity is mediated by vulnerability to fitness‐reducing injury (probabilities of damage, including from infection), Fisherian ...
Bernard Crespi
wiley   +1 more source

Human pain transcriptomics: lessons learned so far. [PDF]

Pain Rep
Hall B, Cook L, Yun S, Kulkarni AB.
europepmc   +1 more source

Changes in brainstem habituation during onabotulinumtoxinA treatment in chronic migraine: A prospective case–control study

Headache: The Journal of Head and Face Pain, Volume 66, Issue 4, Page 950-962, April 2026.
Abstract Objectives/Background Chronic migraine is a debilitating neurological disorder characterized by central sensitization and impaired brainstem habituation. OnabotulinumtoxinA is an established prophylactic treatment for chronic migraine, yet its effects on central trigeminal sensory processing remain incompletely understood.
Gerlinde Freimark, Sebastian Strauss, Lucas H. Overeem, Mira P. Fitzek, Kristin S. Lange, Carolin L. Höhne, Uwe Reuter, Robert Fleischmann, Bianca Raffaelli   +8 more
wiley   +1 more source

Reframing discography through non-binary logic: A dose-response renaissance in spine diagnostics. [PDF]

Interv Pain Med
Stout A.
europepmc   +1 more source

Schwann Cell TRPA1, a Proalgesic Ion Channel, Mediates Neuroinflammation and Fibromyalgia‐Associated Behaviours in Mice

Journal of Neurochemistry, Volume 170, Issue 4, April 2026.
Cellular and molecular mechanisms contributing to TRPA1‐mediated mechanical and cold hypersensitivity and peripheral neuroinflammation in the reserpine‐induced experimental fibromyalgia model. (1) Macrophage‐originated reactive oxygen species (ROS; purple dots) target the transient receptor potential ankyrin 1 (TRPA1) channel localised in Schwann cells.
Evelyne Silva Brum, Maria Fernanda Pessano Fialho, Daniel Souza Monteiro de Araújo, Lorenzo Landini, Matilde Marini, Francesco De Logu, Romina Nassini, Sara Marchesan Oliveira   +7 more
wiley   +1 more source

Mast cell-expressed Mrgprb2/MRGPRX2 mediates gout pain and inflammation via a neuroimmune axis. [PDF]

JCI Insight
Yang L, Liu C, Xiao J, Song Y, Chen H, Li D, Zou C, Hong T, Liu Y, Qi D, Limjunyawong N, Liu W, Qu L.   +12 more
europepmc   +1 more source