Results 161 to 170 of about 39,802 (268)

Immunologic Profiling Suggests an Association Between Treg Cell Dysfunction and Pain in Knee Osteoarthritis

Arthritis &Rheumatology, Volume 78, Issue 4, Page 848-860, April 2026.
Objective Pain is the hallmark symptom of osteoarthritis (OA), and its biologic drivers remain poorly understood. Although the role of innate immunity in OA has been extensively studied, the involvement of adaptive immunity, in particular Treg cells, is not well understood.
Marie Binvignat, Johanna Dubois, Maria Marco Salvador, Paul Stys, Fabien Pitoiset, Alexandra Roux, Michèle Sastre, Signe Hassler, Roberta Lorenzon, Claire Ribet, Vanessa Mhanna, Hélène Vantomme, Leslie Adda, Pierre Barennes, Nicolas Coatnoan, Kenz Le Gouge, Caroline Aheng, Alice Courties, Lise Minssen, Atul J. Butte, Adrien Six, Michelle Rosenzwajg, Nicolas Tchitchek, Francis Berenbaum, David Klatzmann, Encarnita Mariotti‐Ferrandiz, Jérémie Sellam   +26 more
wiley   +1 more source

A review of preclinical research on mechanically gated ion channels as therapeutic targets in neuropathic pain. [PDF]

Ann Med
Xie Y, Wang X, Ju J, Hang L.
europepmc   +1 more source

Activation of GPR35 in the Anterior Cingulate Cortex Alleviates Neuropathic Pain and Depression‐Related Behavior

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
Sciatic nerve injury led to a significant increase in the expression of GPR35 in the ACC region of mice. This increased interaction with Nr4a1 can activate the PI3K/AKT signaling pathway, thereby reducing neuroinflammation and playing a role in alleviating hyperalgesia and depressive behavior in mice. ACC, anterior cingulate cortex.
Jianling Xu, Jingyong Zhou, Xiaojun Li, Tingting Qu, Changjian Zheng, Qingyu Cheng, Xiuyang Lei, Weidong Yao, Yongquan Chen, Bin Wang   +9 more
wiley   +1 more source

The vessel-to-neuron trigeminovascular hypothesis of migraine pathogenesis - the 'pro' argument. [PDF]

J Headache Pain
Christensen RH, Ashina H, Ashina M.
europepmc   +1 more source

A Review of Vagus Nerve Stimulation for Disease: Comprehensive Theory and Evidence for Mechanisms of Action

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Vagus nerve stimulation (VNS) effects span central and peripheral organ systems through diverse mechanistic pathways. This comprehensive review provides a unified synthesis of these mechanisms across neurological, cardiovascular, immunological, metabolic, and gastrointestinal domains, filling a critical gap and serving as a foundational resource for ...
Yifeng Bu, Alex Liang, Benjamin U. Hoffman, Dawn M. Schiehser, Oliver Case, Alan Simmons, Ruth Klaming, Andres Gottfried‐Blackmore, Ravinder K. Mittal, Christopher Puleo, Hubert Lim, Imanuel Lerman   +11 more
wiley   +1 more source

The nociceptor primary cilium. [PDF]

Brain
Ganter GK, Reveche HC, Fitzsimons LA, Khomula EV, Levine JD, Tucker KL.   +5 more
europepmc   +1 more source

Effect of Different Sodium Hypochlorite Concentrations on Post Endodontic Pain: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Clinical and Experimental Dental Research, Volume 12, Issue 2, April 2026.
ABSTRACT Objective The aim of the present systematic review and meta‐analysis was to evaluate the effect of different concentrations of sodium hypochlorite (NaOCl) on post‐operative pain following root canal treatment. Material and Methods The current study was conducted according to PRISMA guidelines and registered on PROSPERO (CRD42023451576).
Kavalipurapu Venkata Teja, Kaligotla Apoorva Vasundhara, Romeo Patini, Salvatore Scolavino, Gianrico Spagnuolo, Flavia Iaculli, Mariangela Cernera   +6 more
wiley   +1 more source

From nociception in aneural animals to human suffering: toward a comparative biology of pain. [PDF]

J Exp Biol
Walters ET.
europepmc   +1 more source

Bidirectional Roles of TRPV1 in a Latent Sensitization Model of Myofascial Low Back Pain

European Journal of Pain, Volume 30, Issue 4, April 2026.
ABSTRACT Introduction Chronic primary low back pain (cpLBP) is a global health concern with poorly understood pathomechanisms, potentially involving spinal sensitization. The capsaicin receptor TRPV1 plays a crucial role in sensitization across pain models.
Vivian Blechschmidt, Bastian Schlickenrieder, Jonathan R. Husk, Ulrich Hoheisel, Handan Mörz, Rolf‐Detlef Treede, Wolfgang Greffrath   +6 more
wiley   +1 more source

Spared Nav1.8-positive nociceptors drive persistent tactile hypersensitivity after sciatic nerve crush injury in mice. [PDF]

Pain
Shim SW, Lee YK, Roh D, Lee K, Kim HW, Oh SB.   +5 more
europepmc   +1 more source