Results 141 to 150 of about 39,802 (268)

Anatomical and functional mapping of vagal nociceptive sensory nerve subsets innervating the mouse lower airways by intersectional genetics

The Journal of Physiology, EarlyView.
Abstract figure legend We used an intersectional approach with recombinase‐expressing mice and adeno‐associated virus to map and modulate distinct nociceptive afferents in the vagal ganglia. TRPV1+P2X2+ neurons resided in the nodose ganglion (N), innervated the lungs (many projected into the alveoli) but not the trachea, and projected to the nucleus ...
Mayur J. Patil, Justin Shane Hooper, Seol‐Hee Kim, Parmvir K. Bahia, Nika Pavelkova, Sanjay S. Nair, Teresa S. Darcey, Karina V. Lurye, Meghana Madaram, Jailene Fiallo, Stephen H. Hadley, Thomas E. Taylor‐Clark   +11 more
wiley   +1 more source

Mechanical sensitization of sensory afferents after passive transfer of fibromyalgia IgG

The Journal of Physiology, EarlyView.
Abstract figure legend In addition to widespread pain and fatigue, people with fibromyalgia (FM) experience sensory abnormalities and report lingering, painful sensations after touch or mechanical probing of the skin. Administration of IgG purified from FM patients to mice transfers symptoms and signs of FM.
Mathilde R. Israel, Nisha Vastani, Clive Gentry, Andreas Goebel, Stuart Bevan, David A. Andersson   +5 more
wiley   +1 more source

Distinct effects of fibromyalgia pain, depression and anxiety on perception of affective touch and pain

The Journal of Physiology, EarlyView.
Abstract figure legend Patients with fibromyalgia (FM) and no‐pain controls completed questionnaire‐based ratings of chronic pain, childhood trauma, anxiety and depression. Brief touch stimuli were then administered, including slow brushing at the C‐tactile optimal velocity of 3 cm/s, deep oscillating pressure with a compression sleeve, roboticized ...
Benedetta Albinni, Marisa Zimmerman, Vincent Alasha, Jacob Ross, Lindsey Crankshaw, Sandy R. Hu, Nathaniel Schuster, Laura Case   +7 more
wiley   +1 more source

Affective CT‐touch attenuates cortical responses and subjective attention during temporal summation of second pain

The Journal of Physiology, EarlyView.
Abstract figure legend The study investigated the modulatory effects of affective touch on temporal summation of second pain (TSSP) in 32 romantic couples (N = 64). The design included a dyadic session (partner's CT‐optimal stroking vs. static touch) and an individual session (robotic CT‐touch vs. vibration control).
Márcia da‐Silva, A. Ribeiro‐Carreira, Mariana Oliveira, Adriana Sampaio, Joana Coutinho, Alberto J. González‐Villar   +5 more
wiley   +1 more source

Trafficking and potentiation of Nav1.7 and Nav1.8 channels are mediated by IQGAP1

The Journal of Physiology, EarlyView.
Abstract figure legend IQGAP1 binds to the voltage‐gated Nav1.7 and Nav1.8 channels and TRPA1 channels in sensory neurons. Inflammatory mediators (IM), including PGE2 and TNFα, released during nerve injury and inflammation activate intracellular signalling messengers such as PKA, p38 MAPK and Cdc42 through their respective receptors.
Xuming Zhang, Pabitra Hriday Patra, Jinquan Yang   +2 more
wiley   +1 more source

Coordinated regulation of PIEZO2 by alternative splicing, post‐translational modification, membrane trafficking and protein partners

The Journal of Physiology, EarlyView.
Abstract figure legend Regulatory mechanisms such as alternative splicing, post‐translational modification, membrane trafficking, and protein interactions control channel gating, membrane abundance, and overall activity of PIEZO2. Proper regulation supports PIEZO2‐dependent proprioceptive, somatosensory, nociceptive, pruriceptive and interoceptive ...
Eunice I. Oribamise, Qinglu Li, Mary G. Garry   +2 more
wiley   +1 more source

Activation and sensitization of meningeal nociceptors by PACAP-38: implications for migraine headache. [PDF]

Brain
Christensen RH, Strassman A, Ashina M, Ashina H, Burstein R.   +4 more
europepmc   +1 more source

Drafting the calmodulation playbook: Emerging structural insights into transient receptor potential channel regulation by calmodulin

The Journal of Physiology, EarlyView.
Abstract figure legend Calmodulin (CaM) is a ubiquitous calcium (Ca2+) sensor that translates intracellular Ca2+ signals into modulation of hundreds of effector proteins including ion channels. CaM is increasingly recognized as a key regulator of the transient receptor potential (TRP) channel family, yet the underlying ‘calmodulation playbook’ is only ...
Aden M. Alemayhu, Candice E. Paulsen
wiley   +1 more source

Optimum electrical sinusoidal frequency stimulation to activate C-nociceptors. [PDF]

Pain Rep
Dileep D, Bali K, Soares S, Schmelz M, Rukwied R.   +4 more
europepmc   +1 more source

Viscoelastic and Morphologic Changes in the Lumbar Intervertebral Discs of the 5xFAD Mouse Model of Alzheimer's Disease

JOR SPINE, Volume 9, Issue 2, June 2026.
The intervertebral discs (IVDs) from mice with amyloid pathologies are larger, flatter, and exhibit increased energy absorption, making these IVDs more susceptible to damage. This heightened vulnerability may predispose elderly individuals with AD to disc injuries, accelerating IVD degeneration and spinal pain. ABSTRACT Background Chronic low back pain,
C. E. Gonzalez, C. A. Schurman, K. A. Wilson, B. Schilling, L. M. Ellerby, S. Y. Tang   +5 more
wiley   +1 more source