Results 141 to 150 of about 28,462 (324)
British Journal of Pharmacology, EarlyView.The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan +3 more
wiley +1 more source
Peripheral targets for neuropathic pain
British Journal of Pharmacology, EarlyView.Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour +3 more
wiley +1 more source
Silencing Nociceptors Using DREADDs to Improve Functional Outcomes after Spinal Cord Injury [PDF]
, 2019 A new chemogenetic treatment for inhibition of pain signaling in the peripheral nervous system will be tested using a spinal cord injury model. More than half of spinal cord injury patients experience chronic neuropathic pain that is refractory to ...
Adkins, Robert Lewis
core
The FEBS Journal, EarlyView.Repeated paclitaxel exposure causes long‐lasting nociceptor hyperexcitability and axonal retraction in adult sensory neurons. Using a long‐term primary nociceptor culture, we show that hyperexcitability is mediated by sequential upregulation of NaV1.8, TRPV1, TRPA1, and TRPM8 channels.
Angela Lamberti +3 more
wiley +1 more source
Depletion of noradrenaline inhibits electrically-evoked pain in the skin of the human forearm [PDF]
, 2008 Guanethidine displaces noradrenaline from sympathetic varicosities, and blocks sympathetic noradrenergic neurotransmission by inhibiting the release of noradrenaline from depleted neural stores. The aim of this study was to determine whether depletion of
Drummond, P.D.
core +1 more source
Novel classes of responsive and unresponsive C nociceptors in human skin [PDF]
, 1995 Roland Schmidt +5 more
openalex +1 more source
Nociceptor neuroimmune interactomes reveal cell type- and injury-specific inflammatory pain pathways [PDF]
, 2023 Aakanksha Jain +9 more
openalex +1 more source
The FEBS Journal, EarlyView.Basic excitability alterations that drive irregular spontaneous activity in primary nociceptors during chemotherapy‐induced peripheral neuropathy. Using an in vitro model of repeated paclitaxel application to dorsal root ganglion neurons that produces progressive axonal degeneration, Lamberti and colleagues show that all three basic excitability ...
Edgar T. Walters
wiley +1 more source
Machine Learning Model for Predicting Postoperative Pain in Cases of Irreversible Pulpitis
International Endodontic Journal, EarlyView.ABSTRACT Aim Postoperative pain is a frequent clinical concern following endodontic treatment. This study aimed to develop and validate supervised machine learning models to predict the occurrence of postoperative pain in cases of irreversible pulpitis.
Pedro Felipe de Jesus Freitas +9 more
wiley +1 more source
Sex-specific nociceptor modulation of the apical periodontitis transcriptome
Frontiers in Molecular BiosciencesIntroduction: Apical periodontitis (AP) is a painful disease that develops quickly following dental infections and is primarily characterized by robust inflammation surrounding the tissues of the affected tooth, resulting in disruption of bone ...
Katherine V. Lillis +2 more
doaj +1 more source