Results 131 to 140 of about 28,462 (324)

Pressing Intervention Alleviates Pain in Rats With Myofascial Trigger Points via the TRPV1 Channel in Unmyelinated C-Type Sensory Nerve Fibers

Journal of Integrative Neuroscience
Background: Although pressing intervention is widely used clinically to alleviate pain associated with chronic myofascial trigger points (MTrPs), the mechanisms by which it modulates pain via sensory nerves remain unclear.
Yuqiao Zhang, Liya Tang, Xinyue Lv, Jiangshang Li, Fei Liu, Xiaoxia Kuang, Wu Li   +6 more
doaj   +1 more source

Nociceptors: Their Role in Body’s Defenses, Tissue Specific Variations and Anatomical Update

Journal of Pain Research, 2022
Vladimir N Nikolenko,1,2 Ekaterina M Shelomentseva,2 Maria M Tsvetkova,2 Elina I Abdeeva,1 Dmitriy B Giller,1 Juliya V Babayeva,1 Evgeny E Achkasov,1 Liliya V Gavryushova,3 Mikhail Y Sinelnikov1,4 1First Moscow State Medical University Named After I.M ...
Nikolenko VN, Shelomentseva EM, Tsvetkova MM, Abdeeva EI, Giller DB, Babayeva JV, Achkasov EE, Gavryushova LV, Sinelnikov MY   +8 more
doaj  

Sex differences in nociceptor translatomes contribute to divergent prostaglandin signaling in male and female mice [PDF]

, 2020
Diana Tavares‐Ferreira, Pradipta Ray, Ishwarya Sankaranarayanan, Galo L. Mejia, Andi Wangzhou, Stephanie Shiers, Ruta Uttarkar, Salim Megat, Paulino Barragán‐Iglesias, Gregory Dussor, Armen N. Akopian, Theodore J. Price   +11 more
openalex   +1 more source

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) CM de Lange   +26 more
wiley   +1 more source

Cutaneous inflammation alters nociceptor electrophysiology in guinea pigs but not rats

Biomolecules & Biomedicine
Inflammatory pain hypersensitivity is believed to result, in part, from increased excitability of nociceptive dorsal root ganglion (DRG) neurons. We previously demonstrated in guinea pigs that hindlimb inflammation induces electrophysiological changes ...
Laiche Djouhri , Ahmed Eliwa , Alghalya Al-Emadi , Yehia Y. Hussein , Hissa Al-Suwaidi , Al-Jouhara Albaloshi , Ayman Mustafa, Mohammed Seed Ahmed   +7 more
doaj   +1 more source

Exaptation and Evolutionary Adaptation in Nociceptor Mechanisms Driving Persistent Pain [PDF]

, 2023
Edgar T. Walters
openalex   +1 more source

Neuronal and ion channel mechanisms of noxious heat sensing in mammals: A puzzle of sensory physiology and pharmacology

British Journal of Pharmacology, EarlyView.
Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley   +1 more source

Local Injection of a Selective Endothelin-B Receptor Agonist Inhibits Endothelin-1-Induced Pain-Like Behavior and Excitation of Nociceptors in a Naloxone-Sensitive Manner [PDF]

, 2002
Alla Khodorova, Moin U. Fareed, A. P. Gokin, Gary R. Strichartz, Gudarz Davar   +4 more
openalex   +1 more source

Calretinin-expressing islet cells are a source of pre- and post-synaptic inhibition of non-peptidergic nociceptor input to the mouse spinal cord [PDF]

, 2023
Olivia Davis, Allen C. Dickie, Marami Mustapa, Kieran A. Boyle, Tyler J. Browne, Mark A. Gradwell, Kelly M. Smith, Erika Polgár, Andrew M. Bell, Éva Kókai, Masahiko Watanabe, Hendrik Wildner, Hanns Ulrich Zeilhofer, David D. Ginty, Robert J. Callister, Brett A. Graham, Andrew J. Todd, David I. Hughes   +17 more
openalex   +1 more source

Nociceptors in antimicrobial defense [PDF]

Nature Immunology, 2020
openaire   +2 more sources