Results 131 to 140 of about 39,802 (268)

Sex-specific nociceptor modulation of the apical periodontitis transcriptome

Frontiers in Molecular Biosciences
Introduction: Apical periodontitis (AP) is a painful disease that develops quickly following dental infections and is primarily characterized by robust inflammation surrounding the tissues of the affected tooth, resulting in disruption of bone ...
Katherine V. Lillis, Ruta Grinceviciute, Anibal Diogenes   +2 more
doaj   +1 more source

Unraveling Chronic Pain: From Mechanisms and Risks to Diagnosis and Treatment. [PDF]

MedComm (2020)
Chronic pain arises through distinct molecular pathways categorized into nociceptive, neuropathic, and nociplastic types. Nociceptive pain begins with TRP channel activation in peripheral nociceptors, signaling via Aδ‐ and C‐fibers through the spinal dorsal horn and spinothalamic tracts to the brain, regulated by descending inhibition and involving ...
Dai X, Wang C, Jiang P, Mei X.
europepmc   +2 more sources

Psychophysical changes after total sleep deprivation and experimental muscle pain

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Sleep disturbances exacerbate chronic pain, increase psychological load, and increase inflammation. Delayed onset muscle soreness (DOMS) mimics aspects of chronic pain, predominantly affecting peripheral pain mechanisms, while experimental sleep provocations have been shown to impact central pain mechanisms.
Emma Hertel, Elaxmi Sathiyalingam, Linea Pilgaard, Simone Juline Brommann, Rocco Giordano, Kristian Kjær‐Staal Petersen   +5 more
wiley   +1 more source

From pain to tumor immunity: influence of peripheral sensory neurons in cancer

Frontiers in Immunology
The nervous and immune systems are the primary sensory interfaces of the body, allowing it to recognize, process, and respond to various stimuli from both the external and internal environment.
Ugo Mardelle, Ninon Bretaud, Clara Daher, Vincent Feuillet   +3 more
doaj   +1 more source

Myofascial Release [PDF]

, 2019
Fascia represents an intricate system of connective tissue that permeates throughout the human body. Its matrix of continuous fibers support, protect, divide and suspend both superficial and deep anatomical structures.
Hetherington, Colin S.
core   +1 more source

Effects of Electroacupuncture at ST36 on Visceral Pain and Inflammatory Markers in IBS Rats

Neurogastroenterology &Motility, EarlyView.
Electroacupuncture (EA) at ST36 significantly reduced visceral pain and colonic inflammation in IBS model rats. EA increased pain thresholds, lowered AWR scores, and downregulated key inflammatory mediators (IL‐1β, IL‐6, TNF‐α, TRPV1, NF‐κB). These findings highlight ST36‐targeted EA as a promising therapeutic strategy for IBS visceral hypersensitivity
Ya‐bo Hao, Yan‐lin Liu, Xiao‐mei Wang, Kai Cheng, Qing‐yu Tu, Fei Dai, Xi‐bing Yang   +6 more
wiley   +1 more source

Pore‐guided needle insertion: a simple technique to reduce pain during local anesthesia

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Felipe Bochnia Cerci, Isadora R. Scaburi, Umer Nadir, Stanislav N. Tolkachjov   +3 more
wiley   +1 more source

Analgesic effects of platelet‐rich fibrin (PRF): A systematic review

Periodontology 2000, EarlyView.
Abstract Background Platelet‐rich fibrin (PRF), a second‐generation autologous platelet concentrate, has gained significant interest for its anti‐inflammatory and regenerative characteristics. While its role in tissue healing is well‐recognized, the analgesic potential of PRF remains under‐investigated.
Nathan E. Estrin, Troy B. Tran, Paras Ahmad, Nima Farshidfar, Georgios E. Romanos, Anton Sculean, Richard J. Miron   +6 more
wiley   +1 more source

The effectiveness of aerobic exercise on pain and disability in individuals with neck pain: A systematic review and meta‐analysis

Experimental Physiology, EarlyView.
Abstract The present review aimed to investigate the effectiveness of aerobic exercise (AE) compared to other interventions in decreasing pain intensity and reducing disability in individuals with neck pain. A systematic review (SR) of randomized controlled trials was conducted. This SR was registered in PROSPERO (CRD42021231231).
Ana lzabela Sobral de Oliveira‐Souza, Marie Kempe, Sofia Grimmelsmann, Luiz Felipe Tavares, Ester Moreira De Castro‐Carletti, Angela Viegas Andrade, Liz Dennett, Harry Von Piekartz, Jorge Fuentes Contreras, Susan Armijo‐Olivo   +9 more
wiley   +1 more source

Sex and age differences in mechanical, thermal and wetness perception across skin sites at risk of pressure ulcers: A quantitative sensory testing study

Experimental Physiology, EarlyView.
Abstract Pressure ulcers can be common in the elderly, and loss of sensation can play a fundamental role in the development of these injuries. The aim of this study was to assess the effects of age and sex on non‐noxious thermal and wetness perception (via magnitude estimation), alongside pressure‐ and thermal‐pain thresholds, at the heel, sternum and ...
Miriam Martini, Arianna Ortis, Davide Filingeri, Peter R. Worsley, Evelin Makuc, Manuela Deodato, Luigi Murena, Paolo Manganotti, Alex Buoite Stella   +8 more
wiley   +1 more source