Results 111 to 120 of about 22,526 (252)

Coordinated regulation of PIEZO2 by alternative splicing, post‐translational modification, membrane trafficking and protein partners

The Journal of Physiology, EarlyView.
Abstract figure legend Regulatory mechanisms such as alternative splicing, post‐translational modification, membrane trafficking, and protein interactions control channel gating, membrane abundance, and overall activity of PIEZO2. Proper regulation supports PIEZO2‐dependent proprioceptive, somatosensory, nociceptive, pruriceptive and interoceptive ...
Eunice I. Oribamise, Qinglu Li, Mary G. Garry   +2 more
wiley   +1 more source

Hypoxia‐induced vulnerability of the somatosensory nervous system

The Journal of Physiology, EarlyView.
Abstract figure legend Sensory neurons are highly energy dependent and rely on sufficient oxygen availability to maintain metabolic stability and effective neurocommunication. Within the somatosensory system, even modest reductions in tissue oxygen tension impair neuronal respiration, forcing a shift toward less efficient metabolic pathways that ...
Jack Corbett, Richard P. Hulse
wiley   +1 more source

Drafting the calmodulation playbook: Emerging structural insights into transient receptor potential channel regulation by calmodulin

The Journal of Physiology, EarlyView.
Abstract figure legend Calmodulin (CaM) is a ubiquitous calcium (Ca2+) sensor that translates intracellular Ca2+ signals into modulation of hundreds of effector proteins including ion channels. CaM is increasingly recognized as a key regulator of the transient receptor potential (TRP) channel family, yet the underlying ‘calmodulation playbook’ is only ...
Aden M. Alemayhu, Candice E. Paulsen
wiley   +1 more source

CHRNA3⁺ nociceptors prime the cutaneous sensory interface to enhance electroacupuncture analgesia. [PDF]

Chin Med
Xu W, Zhang D, Tang Y, Wang Y, Wang Z, Xi H, Gao X, Zhu B, Cui X.   +8 more
europepmc   +1 more source

Effects of Transcutaneous Electrical Nerve Stimulation, Electrical Muscle Stimulation, Exercise and Heat on Back Pain—A Randomized Controlled Clinical Exploratory Trial

European Journal of Pain, Volume 30, Issue 6, July 2026.
ABSTRACT Background This randomized controlled study compared different forms of therapy for chronic back pain. Methods Seventy‐nine patients with chronic back pain with a duration of symptoms of more than 6 months were included in the study and randomly assigned to one of four therapy groups (a) sports therapy with a focus on strength training (SG ...
Thorsten Schmidt, Sonja Kossiski, Hanna Kornprobst, Laura von Levern, Dominik M. Schulte, Manon Sendel, Ralf Baron, Janne Gierthmühlen   +7 more
wiley   +1 more source

Relationship Between Central Sensitization and Genetic Polymorphisms—A Case–Control Study in Fibromyalgia

European Journal of Pain, Volume 30, Issue 6, July 2026.
ABSTRACT Background Fibromyalgia is a syndrome characterised by widespread chronic pain, which is believed to be mediated by a state of central sensitisation (CS). Based on the hypothesis that CS itself could have genetic determinants, our aim was to further explore this pathway.
Nicolas Macian, Christian Dualé, Marine Delay, Vincent Leray, Bruno Pereira, Yoan Renaud, Yvonne Gloor, Jules Desmeules, Gisèle Pickering   +8 more
wiley   +1 more source

Deep visual proteomics uncovers nociceptor diversity and pain targets. [PDF]

Nat Commun
Chakrabarti S, Makhmut A, Mohammadi A, Luo W, Wang L, Lewin GR, Coscia F.   +6 more
europepmc   +1 more source

Canoe full of hot paddlers: TRPV1 neurons steering cardiorespiratory control

The Journal of Physiology, EarlyView.
Richard J. A. Wilson, Nicholas Jendzjowsky   +1 more
wiley   +1 more source

Effects of Selective Sphingosine‐1‐Phosphate Receptor 1 Agonist, TRV045, on Evoked Pain Tests: An Exploratory, Four‐Way Cross‐Over Study in Healthy Volunteers

European Journal of Pain, Volume 30, Issue 6, July 2026.
ABSTRACT Introduction Preclinical evidence suggests that dysregulation of the ceramide‐sphingosine‐1‐phosphate (S1P) axis may have analgesic properties. However, currently approved S1PR1 modulators such as fingolimod are hindered for this indication as they induce lymphopenia.
Wouter A. Bakker, P. Eijsvogel, Erica S. Klaassen, Jessica Kim, Ruihua Chen, Mark A. Demitrack, Albert Dahan, Marieke Niesters, Hemme J. Hijma, Geert Jan Groeneveld   +9 more
wiley   +1 more source

Nociceptor neurons shape antiviral immunity. [PDF]

J Neuroinflammation
Thomas I, Roger A, Rafei M, Gee K, Talbot S, Basta S.   +5 more
europepmc   +1 more source