Results 101 to 110 of about 22,526 (252)
Experimental Physiology, EarlyView.Abstract This study evaluates in non‐trained healthy women the influence of oestradiol (E2) on exercise induced muscular damage (EIMD) and performance. Thirty‐six young healthy women performed a step‐exercise until exhaustion, assessing the number of repetitions, pain perception and well‐being (questionnaires, 15 min and at 48 h post‐exercise), blood ...
David Ramiro‐Cortijo +6 more
wiley +1 more source
From pain to tumor immunity: influence of peripheral sensory neurons in cancer
Frontiers in ImmunologyThe nervous and immune systems are the primary sensory interfaces of the body, allowing it to recognize, process, and respond to various stimuli from both the external and internal environment.
Ugo Mardelle +3 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend We used an intersectional approach with recombinase‐expressing mice and adeno‐associated virus to map and modulate distinct nociceptive afferents in the vagal ganglia. TRPV1+P2X2+ neurons resided in the nodose ganglion (N), innervated the lungs (many projected into the alveoli) but not the trachea, and projected to the nucleus ...
Mayur J. Patil +11 more
wiley +1 more source
Mechanical sensitization of sensory afferents after passive transfer of fibromyalgia IgG
The Journal of Physiology, EarlyView.Abstract figure legend In addition to widespread pain and fatigue, people with fibromyalgia (FM) experience sensory abnormalities and report lingering, painful sensations after touch or mechanical probing of the skin. Administration of IgG purified from FM patients to mice transfers symptoms and signs of FM.
Mathilde R. Israel +5 more
wiley +1 more source
High‐altitude headache: Insights into pathophysiology and potential treatment implications
The Journal of Physiology, EarlyView.Abstract figure legend High‐altitude headache occurs during prolonged exposure to low oxygen, such as during ascent to high altitude. Several risk factors increase its likelihood, with the degree of hypoxia, often driven by rapid ascent to greater altitudes, being the most prominent factor.
Marika Falla +3 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Patients with fibromyalgia (FM) and no‐pain controls completed questionnaire‐based ratings of chronic pain, childhood trauma, anxiety and depression. Brief touch stimuli were then administered, including slow brushing at the C‐tactile optimal velocity of 3 cm/s, deep oscillating pressure with a compression sleeve, roboticized ...
Benedetta Albinni +7 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend We tested the hypothesis that cAMP binding to HCN2 channels in nociceptors is a causal driver of neuropathic pain by using TRIP8bnano, a synthetic peptide we previously developed as a selective antagonist of cAMP in HCN channels. TRIP8bnano effectively abolishes cAMP potentiation of HCN2 currents in small‐diameter DRG neurons and
Santiago I. Loya‐Lopez +7 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend The study investigated the modulatory effects of affective touch on temporal summation of second pain (TSSP) in 32 romantic couples (N = 64). The design included a dyadic session (partner's CT‐optimal stroking vs. static touch) and an individual session (robotic CT‐touch vs. vibration control).
Márcia da‐Silva +5 more
wiley +1 more source
Trafficking and potentiation of Nav1.7 and Nav1.8 channels are mediated by IQGAP1
The Journal of Physiology, EarlyView.Abstract figure legend IQGAP1 binds to the voltage‐gated Nav1.7 and Nav1.8 channels and TRPA1 channels in sensory neurons. Inflammatory mediators (IM), including PGE2 and TNFα, released during nerve injury and inflammation activate intracellular signalling messengers such as PKA, p38 MAPK and Cdc42 through their respective receptors.
Xuming Zhang +2 more
wiley +1 more source