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Nociceptor activation and pain [PDF]
Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1985 This paper reviews advances in our knowledge on the physiological properties of human nociceptors and their capacity to signal pain. Conventional microneurography was used in combination with intraneural microstimulation in subjects who estimated the magnitude of pain from nociceptor stimulation.
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Neurotrophins, nociceptors, and pain
Microscopy Research and Technique, 1999It is now well established that neurotrophins play a crucial role in the development of the nervous system. However, there is increasing evidence that the function of neurotrophins persists throughout adulthood. The broad scope of neurotrophin action is well documented in the case of nerve growth factor (NGF) and its effect on nociceptors and ...
Kathryn M. Albers +2 more
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Nociceptors for the 21st Century
Current Review of Pain, 2000This review summarizes recent developments in the context of the neurochemical classification of nociceptors and explores the relationships between functionally and neurochemically defined subgroups. Although the complete picture is not yet available, several lines of intriguing evidence suggest that despite the complexity and diversity of nociceptor ...
Alvarez, Francisco J. +1 more
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1996
Preface Principles of classification and nomenclature relevant to studies of nociceptive neurones PART 1: BASIC ASPECTS OF NOCICEPTOR FUNCTION 1. Pain and the discovery of nociceptors 2. Structure of nociceptor 'endings' 3. Neurochemistry of cutaneous nociceptors 4. Comparative and evolutionary aspects of nociceptor function PART 2: NOCICEPTORS AND THE
Fernando Cervero, Carlos Belmonte
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Preface Principles of classification and nomenclature relevant to studies of nociceptive neurones PART 1: BASIC ASPECTS OF NOCICEPTOR FUNCTION 1. Pain and the discovery of nociceptors 2. Structure of nociceptor 'endings' 3. Neurochemistry of cutaneous nociceptors 4. Comparative and evolutionary aspects of nociceptor function PART 2: NOCICEPTORS AND THE
Fernando Cervero, Carlos Belmonte
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Nociceptors of the Joint with Particular Reference to Silent Nociceptors [PDF]
, 2007 This chapter summarizes recent research on mechanisms by which diseased joints become painful. Joints are supplied with sensory AΒ, Aδ and C fibers.
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Neurotrophins, nociceptors and pain
Current Opinion in Anaesthesiology, 2000Nerve growth factor (NGF) is known to play a key role in the development of hyperalgesia after inflammatory injury. The increased levels of NGF that accompany injury lead to hyperalgesia via peripheral and central spinal mechanisms. New evidence reviewed here indicates that NGF can directly sensitize nociceptive neurones to noxious heat stimuli through
Gary R. Lewin, Paul A. Heppenstall
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Nociceptor plasticity: A closer look
Journal of Cellular Physiology, 2017Nociceptors are receptors specifically involved in detecting a tissue damage and transducing it in an electrical signal. Nociceptor activation provoked by any kind of acute lesion is related to the release of several mediators of inflammation, within the framework of a process defined as “peripheral sensitization.” This results in an exaggerated ...
PACE, Maria Caterina +10 more
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2021
Chronic pain lasting months or longer is very common, poorly treated, and sometimes devastating. Nociceptors are sensory neurons that usually are silent unless activated by tissue damage or inflammation. In humans their peripheral activation evokes conscious pain, and their spontaneous activity is highly correlated with spontaneous pain.
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Chronic pain lasting months or longer is very common, poorly treated, and sometimes devastating. Nociceptors are sensory neurons that usually are silent unless activated by tissue damage or inflammation. In humans their peripheral activation evokes conscious pain, and their spontaneous activity is highly correlated with spontaneous pain.
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Hyperexcitable C nociceptors in fibromyalgia
Annals of Neurology, 2014ObjectiveTo test the hypothesis that peripheral C nociceptor function may be abnormal in fibromyalgia and that C nociceptor dysfunction may contribute to the symptoms reported by these patients.MethodsMicroneurography was used to record C nociceptors of 30 female patients meeting criteria for fibromyalgia and compared with recordings from 17 female ...
Serra +8 more
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