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What Do We Know about Nociplastic Pain?
Nociplastic pain is a recently distinguished type of pain, distinct from neuropathic and nociceptive pain, and is well described in the literature. It is often mistaken for central sensitization. Pathophysiology has not been clearly established with regard to alteration of the concentration of spinal fluid elements, the structure of the white and gray ...
Dariusz Kałka +2 more
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Recently, the International Association for the Study of Pain (IASP) released clinical criteria and a grading system for nociplastic pain affecting the musculoskeletal system.
Eleni Kapreli +2 more
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“Nociplastic Pain”: A Challenge to Nosology and to Nociception
Journal of Pain, 2023The construct of "nociplastic pain" has met with divergent receptions. On the one hand it has been enthusiastically embraced, to the extent of conflation with central sensitization of nociception and the International Classification of Diseases 11th Revision (ICD-11) entity of "primary" pain, and the promulgation of "nociplastic pain syndromes." On the
Milton Cohen +2 more
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Microglia polarization in nociplastic pain: mechanisms and perspectives
AbstractNociplastic pain is the third classification of pain as described by the International Association for the Study of Pain (IASP), in addition to the neuropathic and nociceptive pain classes. The main pathophysiological mechanism for developing nociplastic pain is central sensitization (CS) in which pain amplification and hypersensitivity occur ...
Noha Abdelkader +2 more
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Nociplastic Pain: A Critical Paradigm for Multidisciplinary Recognition and Management
Our understanding of chronic pain has evolved significantly, shifting from a focus on peripheral damage to recognizing the central mechanisms underlying pain perception. This perspective article explores the concept of nociplastic pain, a term introduced
Jacob Ablin
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Objective: The aim of the study was to evaluate the relationship between biochemical, hematological, and inflammatory parameters and pain in patients with nociplastic pain. Methods: In this cross-sectional study, a total of 8632 patients, aged between 20
Cagla Özdemir, Hilal Telli
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Postinjury stimulation triggers a transition to nociplastic pain in mice
Pain, 2021Abstract Acute injury–induced pain can transition to chronic nociplastic pain, which predominantly affects women. To facilitate studies on the underlying mechanisms of nociplastic pain, we developed a mouse model in which postinjury thermal stimulation (intermittent 40°C water immersion for 10 minutes at 2 hours postcapsaicin) prolongs ...
Kali Hankerd +5 more
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Advances in Our Understanding and Treatment of Nociplastic Pain
Neurologic ClinicsNociplastic pain is a distinct pain mechanism arising from amplified and/or dysregulated sensory processing within the central nervous system (CNS). It is clinically characterized by multisite pain as well as nonpainful symptoms including fatigue, sleep, and memory issues. Although nociplastic pain may be the primary or sole pain mechanism, it often co-
Daniel J. Clauw +2 more
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Nociplastic pain: towards an understanding of prevalent pain conditions
The Lancet, 2021Nociplastic pain is the semantic term suggested by the international community of pain researchers to describe a third category of pain that is mechanistically distinct from nociceptive pain, which is caused by ongoing inflammation and damage of tissues, and neuropathic pain, which is caused by nerve damage.
Mary-Ann, Fitzcharles +5 more
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Applying Nociplastic Pain Criteria in Chronic Musculoskeletal Conditions: A Vignette Study
Background/Objectives: The International Association for the Study of Pain (IASP) recently introduced clinical criteria and a grading system to identify nociplastic pain, marking a pivotal step toward improving diagnostic accuracy.
Eleni Kapreli +2 more
exaly +2 more sources

