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Journal of Clinical Medicine, 2021 Recently, the International Association for the Study of Pain (IASP) released clinical criteria and a grading system for nociplastic pain affecting the musculoskeletal system.
Eleni Kapreli +2 more
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What Do We Know about Nociplastic Pain?
Healthcare, 2023 Nociplastic pain is a recently distinguished type of pain, distinct from neuropathic and nociceptive pain, and is well described in the literature. It is often mistaken for central sensitization.
Dariusz Kałka +2 more
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“Nociplastic Pain”: A Challenge to Nosology and to Nociception
Journal of Pain, 2023The construct of "nociplastic pain" has met with divergent receptions. On the one hand it has been enthusiastically embraced, to the extent of conflation with central sensitization of nociception and the International Classification of Diseases 11th Revision (ICD-11) entity of "primary" pain, and the promulgation of "nociplastic pain syndromes." On the
Milton Cohen +2 more
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Microglia polarization in nociplastic pain: mechanisms and perspectives
Inflammopharmacology, 2023 AbstractNociplastic pain is the third classification of pain as described by the International Association for the Study of Pain (IASP), in addition to the neuropathic and nociceptive pain classes. The main pathophysiological mechanism for developing nociplastic pain is central sensitization (CS) in which pain amplification and hypersensitivity occur ...
Noha Abdelkader +2 more
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Nociplastic pain: towards an understanding of prevalent pain conditions
Lancet, The, 2021Nociplastic pain is the semantic term suggested by the international community of pain researchers to describe a third category of pain that is mechanistically distinct from nociceptive pain, which is caused by ongoing inflammation and damage of tissues, and neuropathic pain, which is caused by nerve damage.
Steven P Cohen +2 more
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Towards precision pain medicine for pain after cancer: the Cancer Pain Phenotyping Network multidisciplinary international guidelines for pain phenotyping using nociplastic pain criteria [PDF]
British Journal of Anaesthesia, 2023 Pain after cancer remains underestimated and undertreated. Precision medicine is a recent concept that refers to the ability to classify patients into subgroups that differ in their susceptibility to, biology, or prognosis of a particular disease, or in ...
Emma Rheel +2 more
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Current Medical Research and OpinionObjective: The aim of the study was to evaluate the relationship between biochemical, hematological, and inflammatory parameters and pain in patients with nociplastic pain. Methods: In this cross-sectional study, a total of 8632 patients, aged between 20
Cagla Özdemir, Hilal Telli
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Functional pain disorders – more than nociplastic pain
NeuroRehabilitation, 2020BACKGROUND: Nociplastic pain has been recently introduced as a third mechanistic descriptor of pain arising primarily from alterations of neural processing, in contrast to pain due to tissue damage leading to nociceptor activation (nociceptive) or due to lesion or disease of the somatosensory nervous system (neuropathic).
Stoyan, Popkirov +4 more
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Advances in Our Understanding and Treatment of Nociplastic Pain
Neurologic ClinicsNociplastic pain is a distinct pain mechanism arising from amplified and/or dysregulated sensory processing within the central nervous system (CNS). It is clinically characterized by multisite pain as well as nonpainful symptoms including fatigue, sleep, and memory issues. Although nociplastic pain may be the primary or sole pain mechanism, it often co-
Daniel J. Clauw +2 more
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